108351-91-3

中文名稱化合物 T28319

英文名稱 PD 120697

CAS 108351-91-3

分子式 C11H15N3S

分子量 221.32

MOL 文件 108351-91-3.mol

108351-91-3 結(jié)構(gòu)式

基本信息物理化學(xué)性質(zhì) 應(yīng)用領(lǐng)域常見問題列表

基本信息

中文別名

化合物 T28319

英文別名

PD 120697

物理化學(xué)性質(zhì)

熔點(diǎn)129-132 °C(Solv: ethanol (64-17-5); ethyl ether (60-29-7))

沸點(diǎn)383.6±30.0 °C(Predicted)

密度1.182±0.06 g/cm3(Predicted)

酸度系數(shù)(pKa)7.04±0.40(Predicted)

應(yīng)用領(lǐng)域

用途一

PD 120697 is a dopamine antagonist. It is a novel class of compounds with central dopamine agonist properties. It has been identified as orally active dopamine (DA) agonists with pronounced central nervous system effects in tests that include [3H]-haloperidol and [3H]-N-propylnorapomorphine binding, inhibition of striatal DA synthesis, inhibition of DA neuronal firing, inhibition of spontaneous locomotor activity, and reversal of reserpine-induced depression in rats.

常見問題列表

概述

PD 120697 是一種口服活性的多巴胺 (DA)激動(dòng)劑。PD 120697 抑制紋狀體 DA 合成、DA 神經(jīng)元放電、自發(fā)運(yùn)動(dòng)活動(dòng)，并逆轉(zhuǎn)利血平 (Reserpine (HY-N0480)) 誘導(dǎo)的抑郁癥。