1822331-55-4
中文名稱
化合物 T34173
英文名稱
2-Pyridinecarboxamide, N-[3-[[(1,6-dihydro-1-hydroxy-6-oxo-2-pyridinyl)carbonyl]amino]propyl]-N-[4-[[(1,6-dihydro-1-hydroxy-6-oxo-2-pyridinyl)carbonyl][3-[[(1,6-dihydro-1-hydroxy-6-oxo-2-pyridinyl)carbonyl][2-(4-isothiocyanatophenyl)ethyl]amino]propyl]amino]butyl]-1,6-dihydro-1-hydroxy-6-oxo-
CAS
1822331-55-4
分子式
C43H45N9O12S
分子量
911.94
MOL 文件
1822331-55-4.mol
1822331-55-4 結(jié)構(gòu)式
基本信息
中文別名
化合物 T34173 英文別名
p-SCN-Bn-HOPO2-Pyridinecarboxamide, N-[3-[[(1,6-dihydro-1-hydroxy-6-oxo-2-pyridinyl)carbonyl]amino]propyl]-N-[4-[[(1,6-dihydro-1-hydroxy-6-oxo-2-pyridinyl)carbonyl][3-[[(1,6-dihydro-1-hydroxy-6-oxo-2-pyridinyl)carbonyl][2-(4-isothiocyanatophenyl)ethyl]amino]propyl]amino]butyl]-1,6-dihydro-1-hydroxy-6-oxo-
應(yīng)用領(lǐng)域
用途一
p-SCN-Bn-HOPO is a superior bifunctional chelator for (89)Zr ImmunoPET. In vivo studies demonstrate the successful use of (89)Zr-HOPO-trastuzumab to image BT474 breast cancer with low background, good tumor to organ contrast, and, importantly, very low bone uptake. The reduced bone uptake seen with (89)Zr-HOPO-trastuzumab suggests superior stability of the (89)Zr-HOPO complex.