75219-46-4
75219-46-4 結(jié)構(gòu)式
基本信息
中文別名
化合物 T14344 英文別名
KM-2210bestrabucil
Bestrabucil (KM2210)
Estra-1,3,5(10)-triene-3,17β-diol 3-benzoate 17-[4-[4-[bis(2-chloroethyl)amino]phenyl]-1-oxobutoxy]acetate
Estra-1,3,5(10)-triene-3,17-diol (17β)-, 3-benzoate 17-[2-[4-[4-[bis(2-chloroethyl)amino]phenyl]-1-oxobutoxy]acetate]
物理化學性質(zhì)
沸點804.3±65.0 °C(Predicted)
密度1.1424 (rough estimate)
折射率1.7350 (estimate)
儲存條件-20°C儲存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)4.65±0.50(Predicted)
形態(tài)Solid
顏色Crystals
常見問題列表
生物活性
Atrimustine 是苯丁酸氮芥與 β-雌二醇苯甲酸酯的結(jié)合物，具有抗腫瘤活性。體外研究
Atrimustine (Bestrabucil), a conjugate of chlorambucil and β-estradiol benzoate, has high affinity for tumor cells and enhances the antitumor activity of chlorambucil.The effect of Atrimustine (Bestrabucil), a benzoate of an estradiol-chlorambucil conjugate, is examined on the production of growth factor(s) by Shionogi carcinoma 115 (SC-115) cells, an androgen-responsive cultured cancer cell line. At Atrimustine concentrations of 100 nM-10 μM, concentration-dependent inhibition of growth factor production by SC-115 cells can be demonstrated by 3 H-thymidine uptake assay.