扎替雷定
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- CAS號(hào):
- 85175-67-3
- 英文名:
- Zatebradine
- 英文別名:
- Zatebradine;UL-FS-49 free base;UL-FS-49CL free base;Zatebradine (UL-FS-49;3-(3-((3,4-Dimethoxyphenethyl)(methyl)amino)propyl)-7,8-dimethoxy-4,5-dihydro-1H-benzo[d]azepin-2(3H)-one;2H-3-Benzazepin-2-one, 3-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-
- 中文名:
- 扎替雷定
- 中文別名:
- 扎替雷定;化合物 T13387;化合物 ZATEBRADINE;3-(3-((3,4-二甲氧基苯乙基)(甲基)氨基)丙基)-7,8-二甲氧基-4,5-二氫-1H-苯并[D]氮雜卓-2(3H)-酮
- CBNumber:
- CB11117164
- 分子式:
- C26H36N2O5
- 分子量:
- 456.58
- MOL File:
- 85175-67-3.mol
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扎替雷定化學(xué)性質(zhì)
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沸點(diǎn):
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612.5±55.0 °C(Predicted)
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密度:
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1.115±0.06 g/cm3(Predicted)
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儲(chǔ)存條件:
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2-8°C
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溶解度:
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DMSO : ≥ 50 mg/mL (109.51 mM)
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形態(tài):
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Oil
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酸度系數(shù)(pKa):
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8.99±0.50(Predicted)
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顏色:
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Light brown to brown
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扎替雷定性質(zhì)、用途與生產(chǎn)工藝
Zatebradine (UL-FS-49 (free base); UL-FS-49CL (free base)) 是一種高效的 HCN Channel 抑制劑，其 IC50 值為 1.96 μM。Zatebradine 會(huì)阻止通過(guò)人類 HCN1，HCN2，HCN3 和 HCN4 通道的緩慢內(nèi)向電流，其 IC50 值分別為 1.83 μM，2.21 μM，1.90 μM 和 1.88 μM。
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IC50: 1.96 μM (
HCN channels
)
The use-dependent blockade by Zatebradine of the cardiac pacemaker current from rabbit sino-atrial node cells has an apparent
K
d
of 480 nM.
Zatebradine (0-20 mg/kg; intraperitoneal injection; for 30 minutes; male C57/Bl6-mice) reduces the heart rate dose-dependently from 600 to 200 bpm with
ED
50
value of 1.8 mg/kg and induces increasing arrhythmia.
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Animal Model:
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Male C57/Bl6-mice
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Dosage:
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0 mg/kg, 0.1 mg/kg, 1 mg/kg, 10 mg/kg, 20 mg/kg
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Administration:
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Intraperitoneal injection; for 30 minutes
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Result:
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Observed acute blood glucose reduction, dose-dependently reduced glycated hemoglobin, significantly prevented the decrease of IRI levels at doses of 3 and 10 mg/kg, and no difference in food intake or body weight.
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扎替雷定
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS編號(hào) | 包裝 | 價(jià)格 |
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| 2026/06/05 | HY-13422A | 扎替雷定
Zatebradine | 85175-67-3 | 5mg | 700元 |
| 2026/06/05 | HY-13422A | 扎替雷定
Zatebradine | 85175-67-3 | 10mM * 1mLin DMSO | 703元 |
85175-67-3, 扎替雷定 相關(guān)搜索:
- 抑制劑
- C26H36N2O5
- 化合物 ZATEBRADINE
- 化合物 T13387
- 3-(3-((3,4-二甲氧基苯乙基)(甲基)氨基)丙基)-7,8-二甲氧基-4,5-二氫-1H-苯并[D]氮雜卓-2(3H)-酮
- 扎替雷定
- 85175-67-3
- Zatebradine (UL-FS-49
- 3-(3-((3,4-Dimethoxyphenethyl)(methyl)amino)propyl)-7,8-dimethoxy-4,5-dihydro-1H-benzo[d]azepin-2(3H)-one
- 2H-3-Benzazepin-2-one, 3-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-
- UL-FS-49CL free base
- UL-FS-49 free base
- Zatebradine