GSK2795039
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- CAS號(hào):
- 1415925-18-6
- 英文名:
- GSK2795039
- 英文別名:
- GSK2795039;GSK2795039 ，S8974;GSK-2795039
(GSK 2795039;GSK2795039, 10 mM in DMSO;Inhibitor,Reactive Oxygen Species,NADPH Oxidase,NOX,inhibit,Apoptosis,GSK-2795039,GSK2795039,GSK 2795039;N-(1-isopropyl-3-(1-methylindolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-methyl-1H-pyrazole-3-sulfonamide;1H-Pyrazole-3-sulfonamide, N-[3-(2,3-dihydro-1-methyl-1H-indol-6-yl)-1-(1-methylethyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-methyl-
- 中文名:
- GSK2795039
- 中文別名:
- GSK2795039試劑;GSK2795039試劑;化合物GSK2795039;GSK2795039 抑制劑;GSK2795039 抑制劑;GSK2795039 ,S8974;NOX2抑制劑(GSK2795039);化合物GSK2795039,10 MM DMSO 溶液;N-(1-異丙基-3-(1-甲基吲哚啉-6-基)-1H-吡咯[2,3-B]吡啶-4-基)-1-甲基-1H-吡唑-3-磺酰胺
- CBNumber:
- CB13152080
- 分子式:
- C23H26N6O2S
- 分子量:
- 450.56
- MOL File:
- 1415925-18-6.mol
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GSK2795039化學(xué)性質(zhì)
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沸點(diǎn):
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691.5±65.0 °C(Predicted)
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密度:
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1.39±0.1 g/cm3(Predicted)
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儲(chǔ)存條件:
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2-8°C
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溶解度:
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DMF:30.0(Max Conc. mg/mL);66.58(Max Conc. mM)
DMSO:66.27(Max Conc. mg/mL);147.07(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:4):0.2(Max Conc. mg/mL);0.44(Max Conc. mM)
Ethanol:20.0(Max Conc. mg/mL);44.39(Max Conc. mM)-
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酸度系數(shù)(pKa):
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6.99±0.30(Predicted)
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形態(tài):
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A solid
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顏色:
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White to yellow
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InChIKey:
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FMWVTCZKCXPKFW-UHFFFAOYSA-N
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SMILES:
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N1(C)C=CC(S(NC2C=CN=C3N(C(C)C)C=C(C4=CC5=C(C=C4)CCN5C)C3=2)(=O)=O)=N1
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GSK2795039性質(zhì)、用途與生產(chǎn)工藝
GSK2795039是NADPHoxidase2(NOX2)的抑制劑，可抑制活性氧reactiveoxygenspecies(ROS)的產(chǎn)生，NADPH的消耗并減少細(xì)胞凋亡。
GSK2795039 是 NADPH oxidase 2 (NOX2) 的抑制劑，對(duì)于NOX2介導(dǎo)的HRP/Amplex Red的激活的pIC50值為6.57。GSK2795039 可抑制活性氧reactive oxygen species (ROS)的產(chǎn)生，NADPH的消耗并減少細(xì)胞凋亡。
| Target | Value |
ROS
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NADPH
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NOX2 (HRP/Amplex Red)
(Cell-based assay)
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6.57(pIC50)
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GSK2795039 (25 μM; 24 hours) reduces the combinatory effect of FeSO4 and LPS-increased levels of apoptosis and reduced the presence of caspase-3-positive PC12 cells.
Apoptosis Analysis
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Cell Line:
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PC12 cells
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Concentration:
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25 μM
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Incubation Time:
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24 hours
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Result:
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Reduced apoptosis among PC12 cells.
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GSK2795039 (intraperitoneal injection; 100 mg/kg; 1 hour before) decreases activity in a murine model of acute pancreatitis, reducing the levels of serum amylase triggered by systemic injection of cerulein.
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Animal Model:
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C57BL6 mice
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Dosage:
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100 mg/kg
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Administration:
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Intraperitoneal injection; 100 mg/kg; 1 hour before
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Result:
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Caused 50% reduction in the level of serum amylase activity.
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GSK2795039
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS編號(hào) | 包裝 | 價(jià)格 |
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| 2026/07/06 | S8974 | 1415925-18-6
GSK2795039 | 1415925-18-6 | 5mg | 2370元 |
| 2026/07/06 | S8974 | GSK2795039 | 1415925-18-6 | 10mM (1mL in DMSO) | 2970元 |
1415925-18-6, GSK2795039 相關(guān)搜索:
- 藥靶配體
- 細(xì)胞生物學(xué)試劑
- 抑制劑
- GSK2795039試劑
- GSK2795039 抑制劑
- GSK2795039試劑
- GSK2795039 抑制劑
- GSK2795039 ,S8974
- 化合物GSK2795039,10 MM DMSO 溶液
- N-(1-異丙基-3-(1-甲基吲哚啉-6-基)-1H-吡咯[2,3-B]吡啶-4-基)-1-甲基-1H-吡唑-3-磺酰胺
- 化合物GSK2795039
- NOX2抑制劑(GSK2795039)
- 1415925-18-6
- GSK2795039 ，S8974
- GSK2795039, 10 mM in DMSO
- Inhibitor,Reactive Oxygen Species,NADPH Oxidase,NOX,inhibit,Apoptosis,GSK-2795039,GSK2795039,GSK 2795039
- 1H-Pyrazole-3-sulfonamide, N-[3-(2,3-dihydro-1-methyl-1H-indol-6-yl)-1-(1-methylethyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-methyl-
- GSK-2795039
(GSK 2795039
- N-(1-isopropyl-3-(1-methylindolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-methyl-1H-pyrazole-3-sulfonamide
- GSK2795039