MM 07
|
|
|
- CAS號(hào):
- 1876450-21-3
- 英文名:
- MM 07
- 英文別名:
- MM 07;MM 07 TFA;CRPRLCHKGPMPF(Modification: Disulfide bridge: 1-6)
- 中文名:
- MM 07
- 中文別名:
- MM 07 TFA;激動(dòng)劑多肽MM 07;APELIN受體多肽;MM 07 三氟乙酸鹽;1876450-21-3;MM 07 TFA;化合物：MM 07 CAS:1876450-21-3;化合物:MM 07 CAS:1876450-21-3
- CBNumber:
- CB54797084
- 分子式:
- C67H106N22O14S3
- 分子量:
- 1539.91
- MOL File:
- 1876450-21-3.mol
|
|
|
MM 07化學(xué)性質(zhì)
-
密度:
-
1.52±0.1 g/cm3(Predicted)
-
|
-
儲(chǔ)存條件:
-
Store at -20° C
-
|
-
形態(tài):
-
Solid
-
|
-
酸度系數(shù)(pKa):
-
3.56±0.10(Predicted)
-
|
-
顏色:
-
White to off-white
-
|
-
水溶解性:
-
Souble in water
-
|
-
序列:
-
Cys-Arg-Pro-Arg-Leu-Cys-His-Lys-Gly-Pro-Met-Pro-Phe (Disulfide bridge:Cys1-Cys6)
-
|
MM 07性質(zhì)、用途與生產(chǎn)工藝
MM 07 是一種有偏倚性的 apelin 受體 (apelin receptor) 激動(dòng)劑，在 CHO-K 細(xì)胞中的 KD 值為 300 nM，在人心臟中的 KD 值為 172 nM。
KD: 300 nM (apelin receptor in CHO-K1 cells), 172 nM (apelin receptor in human heart).
MM 07 competes with nanomolar affinities for binding of [Glp
65
,Nle
75
,Tyr
77
] [
125
I]apelin-13 to human apelin receptors in CHO-K1 cells (K
D
, 300 nM) and human heart (K
D
, 172 nM, n=3).
MM 07 causes a dose-dependent increase in cardiac output, and although there is a decrease in vascular resistance, this is without corresponding effects on BP. Administration of SNAP produces a profound fall in BP in both [Pyr
1
]apelin-13 and MM 07-treated groups; however, although cardiac output is significantly increased in response to SNAP in the MM 07 group, it is significantly reduced in the [Pyr
1
]apelin-13 group. Neither peptide causes a significant change in heart rate, respiratory rate, or temperature. Both [Pyr
1
]apelin 13 and MM 07 increases peak velocity above basal levels.
MM 07
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱(chēng) | CAS編號(hào) | 包裝 | 價(jià)格 |
|---|
| 2026/06/05 | HY-108003 | 1876450-21-3
MM 07 | 1876450-21-3 | 1mg | 640元 |
| 2026/06/05 | HY-108003 | 1876450-21-3
MM 07 | 1876450-21-3 | 5mg | 1600元 |
1876450-21-3, MM 07 相關(guān)搜索:
- 目錄肽
- 藥靶配體
- 目錄肽
- 化合物：MM 07 CAS:1876450-21-3
- 化合物:MM 07 CAS:1876450-21-3
- 1876450-21-3;MM 07 TFA
- MM 07 TFA
- MM 07 三氟乙酸鹽
- 激動(dòng)劑多肽MM 07
- APELIN受體多肽
- 1876450-21-3
- MM 07 TFA
- CRPRLCHKGPMPF(Modification: Disulfide bridge: 1-6)
- MM 07