2-Amino-5-chloropyrazine
- CAS No.
- 33332-29-5
- Chemical Name:
- 2-Amino-5-chloropyrazine
- Synonyms
- 5-chloropyrazin-2-amine;A90103;5-Chloro-2-pyrazinamine;5-Amino-2-chloropyrazine;2-AMINO-5-CHLOROPYRAZINE;2-Pyrazinamine, 5-chloro-;2-amino-5-chloropirazidine;2-Amino-5-chloropyrazine >2-AMINO-5-CHLOROPYRAZINE 98%;2- aMino-5- chlorinepyrazine
- CBNumber:
- CB01013296
- Molecular Formula:
- C4H4ClN3
- Molecular Weight:
- 129.55
- MDL Number:
- MFCD03423596
- MOL File:
- 33332-29-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 2-amino-5-chloropyrazine Aldrich | CDS005437 | 100mg | $77.9 |
| 2-Amino-5-chloropyrazine >98.0%(GC)(T) | A2790 | 1g | $42 |
| 2-Amino-5-chloropyrazine >98.0%(GC)(T) | A2790 | 5g | $168 |
| 2-Amino-5-chloropyrazine Asreported | 258522 | 1g | $305 |
| 2-Amino-5-chloropyrazine Asreported | 258522 | 2g | $418 |
| More product size | |||
| Melting point | 122-128℃ |
|---|---|
| Boiling point | 278.5±35.0 °C(Predicted) |
| Density | 1.437±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| pka | 1.74±0.10(Predicted) |
| form | Solid |
| color | Light orange to Yellow to Green |
| InChI | InChI=1S/C4H4ClN3/c5-3-1-8-4(6)2-7-3/h1-2H,(H2,6,8) |
| InChIKey | HWCKAMAVEWVBDO-UHFFFAOYSA-N |
| SMILES | C1(N)=NC=C(Cl)N=C1 |
| CAS DataBase Reference | 33332-29-5(CAS DataBase Reference) |
| UNSPSC Code | 12352200 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36 | |||||||||
| Safety Statements | 26 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29339900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
2-Amino-5-chloropyrazine price More Price(77)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | CDS005437 | 2-amino-5-chloropyrazine Aldrich | 33332-29-5 | 100mg | $77.9 | 2026-04-30 | Buy |
| TCI Chemical | A2790 | 2-Amino-5-chloropyrazine >98.0%(GC)(T) | 33332-29-5 | 1g | $42 | 2026-04-30 | Buy |
| TCI Chemical | A2790 | 2-Amino-5-chloropyrazine >98.0%(GC)(T) | 33332-29-5 | 5g | $168 | 2026-04-30 | Buy |
| Usbiological | 258522 | 2-Amino-5-chloropyrazine Asreported | 33332-29-5 | 1g | $305 | 2026-06-03 | Buy |
| Usbiological | 258522 | 2-Amino-5-chloropyrazine Asreported | 33332-29-5 | 2g | $418 | 2026-06-03 | Buy |
2-Amino-5-chloropyrazine Chemical Properties,Uses,Production
Uses
2-Amino-5-chloropyrazine is a pyrazine compound, mainly used as an organic intermediate.
Chemical Properties
Pale yellow powder
Synthesis
5049-61-6
33332-29-5
General procedure for the synthesis of 2-amino-5-chloropyrazine from 2-aminopyrazine: 2-aminopyrazine (23.86 g, 0.2509 mol) was dissolved in dichloromethane (420 mL) and cooled to 0 °C. Subsequently, N-chlorosuccinimide (33.50 g, 0.2509 mol) was added to the solution. The reaction mixture was stirred at 0 °C for 24 hours. Upon completion of the reaction, the reaction mixture was diluted with water (500 mL) and then dichloromethane was removed by vacuum concentration. The progress of the reaction was monitored by thin-layer chromatography using ethyl acetate to continuously extract the aqueous layer until product was no longer detected in the aqueous layer. The organic layers were combined, dried with sodium sulfate, filtered and concentrated in vacuum. Purification by fast column chromatography (Merck silica gel 60, 70-230 mesh, 25% ethyl acetate/hexane) afforded 2-amino-5-chloropyrazine (2.66 g, 8.2% yield) as a yellow solid with a melting point of 126-128 °C; EI-HRMS m/e calculated value of C4H4ClN3 (M+) 129.0094 and measured value of 129.0090. General procedure for the preparation of 2(R)-(3-chloro-4-methylsulfonyl-phenyl)-3-(4-oxo-cyclohexyl)-propionamide: 2(R)-(3-chloro-4-methylsulfonyl-phenyl)-3-(4-oxo-cyclohexyl)-propionic acid (prepared as in Example 60, 200 mg, 0.56 mmol) and triphenylphosphine (192 mg, 0.73 mmol) in A solution of dichloromethane (4.0 mL) was cooled to 0°C and N-bromosuccinimide (128 mg, 0.73 mmol) was added in small portions. After addition, the reaction mixture was slowly warmed to 25 °C over 30 min. Subsequently, 2-amino-5-chloropyrazine (145 mg, 1.12 mmol) and 2,6-dimethylpyridine (0.28 mL, 2.24 mmol) were added, and the reaction mixture was stirred at 25 °C for 4 hours. After completion of the reaction, the reaction mixture was diluted with dichloromethane (25 mL) and washed sequentially with 10% aqueous hydrochloric acid (1 × 20 mL), saturated aqueous sodium bicarbonate (1 × 20 mL) and water (1 × 20 mL). The organic layer was dried over sodium sulfate, filtered and concentrated in vacuum. Purification by Biotage chromatography (FLASH 40S, silica, 13/7 hexane/ethyl acetate to 2/3 hexane/ethyl acetate) afforded 2(R)-(3-chloro-4-methylsulfonyl-phenyl)-N-(5-chloro-pyrazin-2-yl)-3-(4-oxo-cyclohexyl)-propionamide (137 mg, 52% yield) as a light yellow foam: [α] 23589 = -27.35° (c = 0.49, chloroform); EI-HRMS m/e calculated value C20H21Cl2N3O4S(M + H)+ 470.0703, measured value 470.0705.
References
[1] European Journal of Organic Chemistry, 2016, vol. 2016, # 36, p. 5937 - 5940
[2] Journal of Medicinal Chemistry, 2007, vol. 50, # 19, p. 4746 - 4758
[3] Patent: WO2007/124345, 2007, A2. Location in patent: Page/Page column 12; 27
[4] Journal of Heterocyclic Chemistry, 1982, vol. 19, # 3, p. 673 - 674
[5] Patent: WO2007/124345, 2007, A2. Location in patent: Page/Page column 11-12; 27
2-Amino-5-chloropyrazine Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569262 +86-15003564040 | 1056@dideu.com | China | 3970 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 | deasea125996@gmail.com | China | 2472 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21587 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | 52513593@qq.com | CHINA | 2972 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
View Lastest Price from 2-Amino-5-chloropyrazine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-03-20 | 2-Amino-5-chloropyrazine
33332-29-5
|
$10.00 | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2026-02-02 | 2-Amino-5-chloropyrazine
33332-29-5
|
10g | 98% | 2000tons | Shaanxi Dideu Medichem Co. Ltd | ||
 |
2024-04-24 | 2-Amino-5-chloropyrazine
33332-29-5
|
$5.00 | 1kg | 99.92% | 50000tons | Ouhuang Engineering Materials (Hubei) Co., Ltd |
-
- 2-Amino-5-chloropyrazine
33332-29-5
- $10.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 2-Amino-5-chloropyrazine
33332-29-5
- 98%
- Shaanxi Dideu Medichem Co. Ltd
-
- 2-Amino-5-chloropyrazine
33332-29-5
- $5.00
- 99.92%
- Ouhuang Engineering Materials (Hubei) Co., Ltd
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