2-(5-methoxy-2-methyl-1H-indol-3-yl)acetamide
- CAS No.
- 15992-10-6
- Chemical Name:
- 2-(5-methoxy-2-methyl-1H-indol-3-yl)acetamide
- Synonyms
- 2-(5-Methoxy-2-methyl-3-indolyl)acetamide;1H-Indole-3-acetamide,5-methoxy-2-methyl-;2-(5-methoxy-2-methyl-1H-indol-3-yl)acetamide
- CBNumber:
- CB01255982
- Molecular Formula:
- C12H14N2O2
- Molecular Weight:
- 218.25
- MDL Number:
- MOL File:
- 15992-10-6.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 2-(5-Methoxy-2-methyl-1H-indol-3-yl)acetamide | 308772 | 250.00mg | $30 |
| 2-(5-Methoxy-2-methyl-1H-indol-3-yl)acetamide | 308772 | 1.00g | $63 |
| 2-(5-Methoxy-2-methyl-1H-indol-3-yl)acetamide | 308772 | 5.00g | $191 |
| 2-(5-Methoxy-2-methyl-1H-indol-3-yl)acetamide 97% | M55868 | 100mg | $40 |
| 2-(5-Methoxy-2-methyl-1H-indol-3-yl)acetamide 97% | M55868 | 250mg | $45 |
2-(5-methoxy-2-methyl-1H-indol-3-yl)acetamide price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 308772 | 2-(5-Methoxy-2-methyl-1H-indol-3-yl)acetamide | 15992-10-6 | 250.00mg | $30 | 2026-05-19 | Buy |
| Matrix Scientific | 308772 | 2-(5-Methoxy-2-methyl-1H-indol-3-yl)acetamide | 15992-10-6 | 1.00g | $63 | 2026-05-19 | Buy |
| Matrix Scientific | 308772 | 2-(5-Methoxy-2-methyl-1H-indol-3-yl)acetamide | 15992-10-6 | 5.00g | $191 | 2026-05-19 | Buy |
| Synthonix | M55868 | 2-(5-Methoxy-2-methyl-1H-indol-3-yl)acetamide 97% | 15992-10-6 | 100mg | $40 | 2026-05-06 | Buy |
| Synthonix | M55868 | 2-(5-Methoxy-2-methyl-1H-indol-3-yl)acetamide 97% | 15992-10-6 | 250mg | $45 | 2026-05-06 | Buy |
2-(5-methoxy-2-methyl-1H-indol-3-yl)acetamide Chemical Properties,Uses,Production
Synthesis
53-86-1
15992-10-6
General procedure for the synthesis of 2-(5-methoxy-2-methyl-1H-indol-3-yl)acetamide from 2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetic acid: 2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetic acid (14.3 g, 40 mmol) was Dissolve in anhydrous THF (100 mL) and cool to -10°C. N-methylmorpholine (5 mL, 45 mmol) was added slowly dropwise with vigorous stirring. after 10 min, ethyl chlorocarbonate (4 mL, 42 mmol) was added slowly dropwise for 30 min. Subsequently, NH4OH (100 mL) was added and the reaction mixture was stirred for 3 hours at room temperature. Under stirring, 4 mol/L NaOH solution (200 mL) was slowly added until the solid was completely dissolved. The reaction mixture was partitioned and the aqueous layer was extracted with CH2Cl2 (3 x 200 mL). The organic layers were combined, washed with brine, dried over anhydrous Na2SO4 and concentrated in vacuum to give the crude product. The crude product was washed with water to give white solid 2-(5-methoxy-2-methyl-1H-indol-3-yl)acetamide (7.644 g, 88% yield). The melting point of the product was 153-155°C. 1H-NMR (400MHz, CDCl3) δ: 7.91 (s, 1H), 7.20 (d, J=8.61Hz, 1H), 6.91 (d, J=1.96Hz, 1H), 6.81 (dd, J=2.35Hz, 8.61Hz, 1H), 5.66 (s, 1H), 5.39 (s, 1H), 3.84 (s, 3H), 3.64 (s, 2H), 2.39 (s, 3H).ESI-MS m/z: 219.1 [M+H]+.
References
[1] Bioorganic and Medicinal Chemistry Letters, 2005, vol. 15, # 20, p. 4540 - 4542
[2] Letters in Drug Design and Discovery, 2016, vol. 13, # 10, p. 1025 - 1032
[3] Chinese Journal of Chemistry, 2013, vol. 31, # 9, p. 1164 - 1170
2-(5-methoxy-2-methyl-1H-indol-3-yl)acetamide Preparation Products And Raw materials
2-(5-methoxy-2-methyl-1H-indol-3-yl)acetamide Suppliers
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