AC-YVAD-CMK
- CAS No.
- 178603-78-6
- Chemical Name:
- AC-YVAD-CMK
- Synonyms
- AC-YVAD-CMK;ICE INHIBITOR II;AC-TYR-VAL-ALA-ASP-CMK;CASPASE-1 INHIBITOR II;AC-TYR-VAL-ALA-ASP-CH2CL;N-Ac-Tyr-Val-Ala-Asp-CMK;5-Trihydroxybenzoic acid;Ac-YVAD-cmk >=95% (HPLC);AC-YVAD-CHLOROMETHYLKETONE;AC-TYR-ALA-ASP-CHLOROMETHYLKETONE
- CBNumber:
- CB0168634
- Molecular Formula:
- C24H33ClN4O8
- Molecular Weight:
- 540.99
- MDL Number:
- MFCD00237124
- MOL File:
- 178603-78-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Ac-YVAD-cmk ≥95% (HPLC) | SML0429 | 1mg | $121 |
| Caspase-1 Inhibitor II | 400012 | 5mg | $366 |
| Ac-YVAD-CMK ≥98% | 10014 | 500μg | $42 |
| Ac-YVAD-CMK ≥98% | 10014 | 1mg | $79 |
| Ac-YVAD-CMK ≥98% | 10014 | 5mg | $322 |
| More product size | |||
| Melting point | >205°C (dec.) |
|---|---|
| RTECS | AY3079566 |
| storage temp. | -20°C |
| solubility | DMSO (Slightly, Sonicated), Methanol (Slightly, Heated, Sonicated) |
| form | White solid |
| color | white to off-white |
| Stability | Hygroscopic |
| InChIKey | CQZPAKWASFYDKD-DGJUNBOTSA-N |
| SMILES | C(N)(=O)[C@H](C)N(C(=O)[C@H](C(C)C)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(C)=O)[C@@H](CC(O)=O)C(=O)CCl |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
| WGK Germany | 3 |
| Storage Class | 11 - Combustible Solids |
AC-YVAD-CMK price More Price(77)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0429 | Ac-YVAD-cmk ≥95% (HPLC) | 178603-78-6 | 1mg | $121 | 2026-04-30 | Buy |
| Sigma-Aldrich | 400012 | Caspase-1 Inhibitor II | 178603-78-6 | 5mg | $366 | 2026-04-30 | Buy |
| Cayman Chemical | 10014 | Ac-YVAD-CMK ≥98% | 178603-78-6 | 500μg | $42 | 2026-04-30 | Buy |
| Cayman Chemical | 10014 | Ac-YVAD-CMK ≥98% | 178603-78-6 | 1mg | $79 | 2026-04-30 | Buy |
| Cayman Chemical | 10014 | Ac-YVAD-CMK ≥98% | 178603-78-6 | 5mg | $322 | 2026-04-30 | Buy |
AC-YVAD-CMK Chemical Properties,Uses,Production
Uses
Ac-YVAD-CMK is a selective, irreversible inhibitor of interleukin-1β converting enzyme (ICE; Caspase-1). Ac-YVAD-CMK is neuroprotective in a rat model of cerebral ischemia.[Cayman Chemical]
Uses
Ac-YVAD-cmk has been used:
- as an inflammasome inhibitor to add to THP-1 cells or PBMC (peripheral blood mononuclear cell) before stimulation
- as a caspase-1 inhibitor injected to C57BL/6 mice
- as a caspase-1 inhibitor, administered into mice before and during hematopoietic stem cell transplantation (HSCT) to evaluate its effect on bone marrow inflammatory injury
- to abolish the histidine-rich protein II (HRPII) effect on transendothelial electrical resistance (TEER)
- as caspase 1 inhibitor, to treat MCF-7 tumor xenograft mice, to validate the role of inflammasomes activation in tumor growthin vivocondition
General Description
Interleukin-1β converting enzyme (ICE) is a cysteine protease that cleaves the IL-1β precursor to mature IL-1β. Caspase-1 inhibitor II is a cell-permeable, irreversible inhibitor of Caspase-1, Caspase-4, and Caspase-5. Inhibits CPP32/Apopain at a much higher concentration. Inhibits Fas-mediated apoptosis and acidic sphingomyelinase activation.
Biochem/physiol Actions
Ac-YVAD-cmk is a selective ireversible inhibitor of caspase-1 (interleukin-1β converting enzyme, ICE) with some activity also against caspase-4. Ac-YVAD-cmk is anti-apoptotic and has anti-inflammatory and neuroprotective effects, thought to result from its preventing caspase-1 activation of the proinflammatory cytokine, Interleukin-1β.
in vivo
Ac-YVAD-cmk treatment (1 μg/rats; SD rat; injected into the left lateral ventricle) significantly decreases the protein levels of caspase-1 (p20), mature IL-1β/IL-18 compared with the ICH group[2].
Ac-YVAD-cmk (rats with ac-YVAD-cmk at a dose of 12.5 μmol/kg) significantly reduces mortality from 83 to 33% using Log Rank analysis[3].
IC 50
Caspase-1
AC-YVAD-CMK Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19853 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471; | sales@sarms4muscle.com | China | 10473 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19908 | 58 |
| Nanjing TGpeptide | +86-13347807150 | support@tgpeptide.com | China | 3279 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501; +undefined18621343501 | product@acmec-e.com | China | 33324 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | cooperation@kean-chem.com | China | 40066 | 58 |
| Changsha MOL Changes Biotechnology Co., Ltd. | +8619375158599 | info@molchanges.com | China | 5218 | 58 |
View Lastest Price from AC-YVAD-CMK manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-22 | Ac-YVAD-CMK
178603-78-6
|
$64.00-372.00 | 99.90% | 10g | TargetMol Chemicals Inc. |
-
- Ac-YVAD-CMK
178603-78-6
- $64.00-372.00
- 99.90%
- TargetMol Chemicals Inc.
