METHYL 4-HYDROXY-2H-THIENO[2,3-E]-1,2-THIAZINE-3-CARBOXYLATE-1,1-DIOXIDE
![METHYL 4-HYDROXY-2H-THIENO[2,3-E]-1,2-THIAZINE-3-CARBOXYLATE-1,1-DIOXIDE Structure](CAS/GIF/98827-44-2.gif)
- CAS No.
- 98827-44-2
- Chemical Name:
- METHYL 4-HYDROXY-2H-THIENO[2,3-E]-1,2-THIAZINE-3-CARBOXYLATE-1,1-DIOXIDE
- Synonyms
- Albb-008913;Tenoxicam Impurity 7;Tenoxicam Impurity 1;Lornoxicam Impurity 56;Methyl 4-hydroxy-2H-thieno[2,3-e]-1,2-thiazine-3-carboxylate...;methyl 4-hydroxy-1,1-dioxo-2H-thieno[2,3-e]thiazine-3-carboxylate;Thyl 4-Hydroxy-2H-Thieno[2,3-E][1,2]Thiazine-3-Carboxylate 1,1-Dioxide;METHYL 4-HYDROXY-2H-THIENO[2,3-E]-1,2-THIAZINE-3-CARBOXYLATE-1,1-DIOXIDE;methy1 4-hydroxy-2H-thieno[2,3 -e]-1,2-thiazine-3-carboxylate-1, 1-dioxide;2H-Thieno[2,3-e]-1,2-thiazine-3-carboxylic acid, 4-hydroxy-, methyl ester, 1,1-dioxide
- CBNumber:
- CB0186414
- Molecular Formula:
- C8H7NO5S2
- Molecular Weight:
- 261.27
- MDL Number:
- MFCD08460399
- MOL File:
- 98827-44-2.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Methyl 4-hydroxy-2H-thieno[2,3-e][1,2]thiazine-3-carboxylate 1,1-dioxide | 039962 | 500.00mg | $126 |
| Methyl 4-Hydroxy-2H-Thieno[2,3-E][1,2]Thiazine-3-Carboxylate 1,1-Dioxide ≥98% | AA00671W | 25mg | $178 |
| Methyl 4-Hydroxy-2H-Thieno[2,3-E][1,2]Thiazine-3-Carboxylate 1,1-Dioxide ≥98% | AA00671W | 100mg | $357 |
| Methyl 4-Hydroxy-2H-Thieno[2,3-E][1,2]Thiazine-3-Carboxylate 1,1-Dioxide ≥98% | AA00671W | 250mg | $567 |
| Methyl 4-hydroxy-2H-thieno[2,3-e][1,2]thiazine-3-carboxylate 1,1-dioxide 95+% | CD11000844 | 5g | $392 |
| More product size | |||
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
| HazardClass | IRRITANT |
METHYL 4-HYDROXY-2H-THIENO[2,3-E]-1,2-THIAZINE-3-CARBOXYLATE-1,1-DIOXIDE price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 039962 | Methyl 4-hydroxy-2H-thieno[2,3-e][1,2]thiazine-3-carboxylate 1,1-dioxide | 98827-44-2 | 500.00mg | $126 | 2026-05-18 | Buy |
| aablocks | AA00671W | Methyl 4-Hydroxy-2H-Thieno[2,3-E][1,2]Thiazine-3-Carboxylate 1,1-Dioxide ≥98% | 98827-44-2 | 25mg | $178 | 2026-05-28 | Buy |
| aablocks | AA00671W | Methyl 4-Hydroxy-2H-Thieno[2,3-E][1,2]Thiazine-3-Carboxylate 1,1-Dioxide ≥98% | 98827-44-2 | 100mg | $357 | 2026-05-28 | Buy |
| aablocks | AA00671W | Methyl 4-Hydroxy-2H-Thieno[2,3-E][1,2]Thiazine-3-Carboxylate 1,1-Dioxide ≥98% | 98827-44-2 | 250mg | $567 | 2026-05-28 | Buy |
| Crysdot | CD11000844 | Methyl 4-hydroxy-2H-thieno[2,3-e][1,2]thiazine-3-carboxylate 1,1-dioxide 95+% | 98827-44-2 | 5g | $392 | 2026-05-26 | Buy |
METHYL 4-HYDROXY-2H-THIENO[2,3-E]-1,2-THIAZINE-3-CARBOXYLATE-1,1-DIOXIDE Chemical Properties,Uses,Production
Synthesis
![Methyl 3-[(methoxycarbonylmethyl)sulfamoyl]thiophene-2-carboxylate](/CAS/GIF/106820-63-7.gif)
106820-63-7
![METHYL 4-HYDROXY-2H-THIENO[2,3-E]-1,2-THIAZINE-3-CARBOXYLATE-1,1-DIOXIDE](/CAS/GIF/98827-44-2.gif)
98827-44-2
General procedure for the synthesis of 4-hydroxy-2H-thieno[2,3-e]-1,2-thiazine-3-carboxylic acid methyl ester-1,1-dioxide from methyl 3-sulfonamidoacetate-2-thiophenecarboxylate: 8.5 g of methyl 3-sulfonamidoacetate-2-thiophenecarboxylic acid methyl ester (TNXK-1), 27.2 g of a 7% sodium methanol solution, and 15 mL of anhydrous methanol were mixed. The reaction was heated to reflux with stirring and maintained for 2 hours. After completion of the reaction, it was cooled to room temperature and the reaction mixture was diluted with 200 mL of water. Subsequently, the reaction mixture was neutralized with 10% hydrochloric acid solution to pH 3. After neutralization, the solvent was removed by evaporation, the residue was cooled, and the pH was adjusted again with 10% hydrochloric acid to 3. The precipitate was collected by filtration, and the filter cake was washed with water and dried to give 5.6 g of the yellowish-green solid product, 4-hydroxy-2H-thieno[2,3-e]-1,2-thiazine-3-carboxylic acid methyl ester-1,1 -dioxide (TNXK-2) The yield was 79%.
References
[1] Patent: CN107141308, 2017, A. Location in patent: Paragraph 0046-0050; 0064; 0068; 0074; 0078; 0084; 0088
[2] Journal of Medicinal Chemistry, 1987, vol. 30, # 4, p. 678 - 682
METHYL 4-HYDROXY-2H-THIENO[2,3-E]-1,2-THIAZINE-3-CARBOXYLATE-1,1-DIOXIDE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30225 | 58 |
| CD Chemical Group Limited | +8615986615575 | info@codchem.com | China | 17259 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25356 | 58 |
| Golden Pharma Co., Limited | +undefined18958062155 | sales@zjgoldpharm.com | China | 5899 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| Changzhou AniKare Pharmatech Co., Ltd. | +86-0519-8359-8696 +8618018249389 | sales@anikare.com | China | 9969 | 58 |
| XIAMEN AMITY INDUSTRY AND TRADE CO., LTD. | +8618950047208 | ellena@amitychem.com | China | 43414 | 58 |
| ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | +86-13017695106 +86-13676922317 | jiuyitime@fdachem.com | China | 16512 | 58 |
| QUALITY CONTROL SOLUTIONS LTD. | +86-0755-66853366 +8613670046396 | export03@qcsrm.com | China | 24342 | 58 |
98827-44-2(METHYL 4-HYDROXY-2H-THIENO[2,3-E]-1,2-THIAZINE-3-CARBOXYLATE-1,1-DIOXIDE)Related Search:
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