ChemicalBook >> CAS DataBase List >>L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid
L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid
- CAS No.
- 74163-81-8
- Chemical Name:
- L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid
- Synonyms
- Tic-OH;(S)-TIC;L-TIC HCL;L-1,2,3,4-Tetrahydro;Icatibant Impurity 14;Quinapril Bicyclic Acid;Quinapril EP Impurity A;(S)-1,2,3,4-Tetrahydro-3-isoquinoL;Quinapril Hydrochloride Impurity A;(3S)-1,2,3,4-Tetrahydroisoquinoline
- CBNumber:
- CB0197924
- Molecular Formula:
- C10H11NO2
- Molecular Weight:
- 177.2
- MDL Number:
- MFCD00800357
- MOL File:
- 74163-81-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Last updated:2026-05-27 17:21:34
| Product description | Number | Pack Size | Price |
| (S)-1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic acid 97% | 421626 | 5g | $27.5 |
| (S)-(-)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acid >98.0%(T) | T1515 | 5g | $55 |
| (S)-(-)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acid >98.0%(T) | T1515 | 25g | $159 |
| (S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acid | TRC-T293755-5G | 5g | $65 |
| (S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acid | TRC-T293755-25G | 25g | $246 |
| More product size | |||
| Melting point | >300 °C(lit.) |
|---|---|
| Boiling point | 309.12°C (rough estimate) |
| alpha | -157.4 º (24 ºC) |
| Density | 1.1607 (rough estimate) |
| refractive index | -166 ° (C=1, 1mol/L NaOH) |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | soluble in Hot Water, Basic Water |
| pka | 2.21±0.20(Predicted) |
| form | powder to crystal |
| color | White to Almost white |
| optical activity | [α]20/D 168°, c = 1.8 in 1.4 M NaOH |
| BRN | 4842199 |
| Major Application | peptide synthesis |
| InChI | 1S/C10H11NO2/c12-10(13)9-5-7-3-1-2-4-8(7)6-11-9/h1-4,9,11H,5-6H2,(H,12,13)/t9-/m0/s1 |
| InChIKey | BWKMGYQJPOAASG-VIFPVBQESA-N |
| SMILES | OC(=O)[C@@H]1Cc2ccccc2CN1 |
| CAS DataBase Reference | 74163-81-8(CAS DataBase Reference) |
| FDA UNII | 737G46U1NP |
| UNSPSC Code | 12352106 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29334900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
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| NFPA 704 |
|
L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid price More Price(80)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 421626 | (S)-1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic acid 97% | 74163-81-8 | 5g | $27.5 | 2026-04-30 | Buy |
| TCI Chemical | T1515 | (S)-(-)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acid >98.0%(T) | 74163-81-8 | 5g | $55 | 2026-04-30 | Buy |
| TCI Chemical | T1515 | (S)-(-)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acid >98.0%(T) | 74163-81-8 | 25g | $159 | 2026-04-30 | Buy |
| TRC | TRC-T293755-5G | (S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acid | 74163-81-8 | 5g | $65 | 2026-06-03 | Buy |
| TRC | TRC-T293755-25G | (S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acid | 74163-81-8 | 25g | $246 | 2026-06-03 | Buy |
L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid Chemical Properties,Uses,Production
Description
(S)-(-)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid is a quinoline derivative, which is used as an intermediate in the synthesis of quinapril. Quinapril, a product developed by Pfizer, was approved by the US FDA in 1991 for the treatment of hypertension, congestive heart failure and angioedema.
Chemical Properties
white to light yellow crystal powde
Uses
(S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acid (Quinapril EP Impurity A) is a Quinapril intermediate.
reaction suitability
reaction type: solution phase peptide synthesis
L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
(S)-N-tert-Butyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
2-BENZOYL-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID
(3S)-7-nitro-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER
1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid methyl ester
1of2
Global( 344)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10403 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8615060885618 | sales@amoychem.com | China | 6366 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10000 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9636 | 58 |
View Lastest Price from L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-04-04 | L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid
74163-81-8
|
1KG | 98% | 1ton | Henan Aochuang Chemical Co.,Ltd.
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2021-08-12 | L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid
74163-81-8
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2021-07-02 | (S)-(-)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acid
74163-81-8
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid
74163-81-8
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid
74163-81-8
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- (S)-(-)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acid
74163-81-8
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
74163-81-8(L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid)Related Search:
Tetrahydrofuran
1,2,3,4-TETRAHYDROISOQUINOLINE
Tetramethylammonium hydroxide pentahydrate
Isoquinoline
Potassium hydrogen phthalate
Isoquinoline-1-carboxylic acid
5,6,7,8-TETRAHYDROISOQUINOLINE
cis-1,2,3,6-Tetrahydrophthalic anhydride
2-Tetrahydrofuroic acid
H-TLE-OTBU HCL
1of4
(S)-TIC
(S)-N-tert-1,2,3,4-tetrahydroisoquinoline -3-carboxamide
L-1,2,3,4-Tetrahydro
4-Tetrahydro-3-Isoquinolinecarboxylic acid
[S]-1,2,3,4-Tetrahydro-3-Isoquinolingcarboxylic Acid
(S)-1, 2, 3, 4-tetrahydro-3-isoquinolinecarboxylic acid (for Quinapril)
L-1,2,3,4-Tetrahydroisoquinoline-3-CarboxylicAcid98%
(S)-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINECARBOXYLIC ACID METHYLESTHER
(3S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLICACIDHYDROCHLORIDE
L-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC
(S)-1,2,3,4-Tetrahydro-3-isoquinolinecarboxlicacid
(S)-1,2,3,4-Tetrahydro-3-isoquinoline-carboxylic aci
L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid
1,2,3,4-Tetrahydroisoquinoline-3-carboxxylic acid
(S)-1,2,3,4-TERTRAHYDRO-3-ISOQUINOLINECARBOXYLIC ACID
(3S)-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINECA
(S)-1,2,3,4-Tetrahydro-3-isoquinoline-carboxylic acid hydrochloride, 95+%
(S)-(-)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylicacid,97%
(S)-(-)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid
Quinapril Bicyclic Acid
(S)-1,2,3,4-TETRAHYDO-3-ISOQUINOLINECARBOXYLIC ACID HCL
(S)-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINECARBOXYLIC ACID HCL SALT
(S)-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINECARBOXYLIC ACID HYDROCHLORIDE
(S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID HCL
S-(-)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID HYDROCHLORIDE
(3S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid≥ 98% (HPLC)
Tic-OH
(S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acid,99%e.e.
(3S)-1,2,3,4-Tetrahydro-3-isoquinolinecarbocylic acid for synthesis
L-TIC HCL
L-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID HYDROCHLORIDE
3-ISOQUINOLINECARBOXYLIC ACID, 1,2,3,4-TETRAHYDRO-,(3S)-
Quinapril EP Impurity A
Quinapril Impurity 1（Quinapril EP Impurity A）
(3S)-1,2,3,4-Tetrahydroisoquinoline
(S)-1,2,3,4-Tetrahydro-3-isoquinoL
[S]-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINGCARBOXYLIC ACID (CAS:74163-81-8)
L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid USP/EP/BP
(S)-(-) 1,2,3, 4-Tetrahydroisoquinoline -3-Carboxylic Acid pure, 98%
(-)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid
Quinapril Hydrochloride EP Impurity A
(-)-1,2,3,4-Tetrahydro-isoquinolin-3-carboxylic acid
Icatibant Impurity 14
(S)-1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic acid
Quinapril Hydrochloride Impurity A
74163-81-8
Others
Peptide Synthesis
Unnatural Amino Acid Derivatives
Specialty Synthesis
Carboxylic Acids
(intermediate of quinapril)
Carboxylic Acids
Quinolines, Isoquinolines & Quinoxalines
chiral
Amino Acids
Chiral Reagents
Heterocycles
