1-N-BOC-MORPHOLINE
- CAS No.
- 220199-85-9
- Chemical Name:
- 1-N-BOC-MORPHOLINE
- Synonyms
- tert-Butyl Morpholine-4-carboxylate;N-Boc-Morpholine;1-N-BOC-MORPHOLINE;4-Boc-morpholine, 98%;Sitagliptin Impurity 134;4-Morpholinecarboxylic acid tert-butyl ester; 4-Morpholinecarboxylic acid, 1,1-dimethylethyl ester
- CBNumber:
- CB02456290
- Molecular Formula:
- C9H17NO3
- Molecular Weight:
- 187.24
- MDL Number:
- MFCD11111782
- MOL File:
- 220199-85-9.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| tert-butyl morpholine-4-carboxylate 97% | OR903410 | 25g | $22 |
| tert-butyl morpholine-4-carboxylate 97% | OR903410 | 100g | $67 |
| tert-butyl morpholine-4-carboxylate 97% | OR903410 | 500g | $327 |
| tert-butyl morpholine-4-carboxylate 97% | OR903410 | 2.5kg | $1502 |
| tert-butyl morpholine-4-carboxylate 97% | OR903410 | 25g | $22 |
| More product size | |||
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
| HS Code | 2934999090 |
1-N-BOC-MORPHOLINE price More Price(45)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR903410 | tert-butyl morpholine-4-carboxylate 97% | 220199-85-9 | 25g | $22 | 2026-06-04 | Buy |
| Apolloscientific | OR903410 | tert-butyl morpholine-4-carboxylate 97% | 220199-85-9 | 100g | $67 | 2026-06-04 | Buy |
| Apolloscientific | OR903410 | tert-butyl morpholine-4-carboxylate 97% | 220199-85-9 | 500g | $327 | 2026-06-04 | Buy |
| Apolloscientific | OR903410 | tert-butyl morpholine-4-carboxylate 97% | 220199-85-9 | 2.5kg | $1502 | 2026-06-04 | Buy |
| Apolloscientific | OR903410 | tert-butyl morpholine-4-carboxylate 97% | 220199-85-9 | 25g | $22 | 2026-06-04 | Buy |
1-N-BOC-MORPHOLINE Chemical Properties,Uses,Production
Synthesis
110-91-8
24424-99-5
220199-85-9
The general procedure for the synthesis of tert-butyl morpholine-4-carboxylate from morpholine and di-tert-butyl dicarbonate is as follows: morpholine (1 mmol) is added to a solution of guanidine hydrochloride (15 mol%) and di-tert-butyl dicarbonate (1.2 mmol) in ethanol (1 mL) containing a magnetic stirrer, and the mixture is stirred at 35-40 °C until the reaction is complete (monitored by TLC or GC). Upon completion of the reaction, the ethanol is evaporated under vacuum and the residue is washed with water to remove the catalyst or dissolved in dichloromethane (or ethyl acetate) and filtered to separate the catalyst. If an organic solvent is used for post-treatment, evaporation of the organic solvent gives an almost pure product. If excess di-tert-butyl dicarbonate is used, the product can be washed with petroleum ether or hexane to recover the residual di-tert-butyl dicarbonate. If necessary, the product can be further purified by crystallization (using a solvent mixture of hexane and dichloromethane, or ethyl ether and petroleum ether) or by silica gel column chromatography (using ethyl acetate-hexane, 1:6, as eluent).
References
[1] Tetrahedron Letters, 2006, vol. 47, # 46, p. 8039 - 8042
[2] Synthesis, 2006, # 16, p. 2784 - 2788
[3] Tetrahedron Letters, 2008, vol. 49, # 16, p. 2527 - 2532
[4] Tetrahedron Letters, 2011, vol. 52, # 12, p. 1260 - 1264
[5] Monatshefte fur Chemie, 2011, vol. 142, # 10, p. 1035 - 1043
1-N-BOC-MORPHOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30225 | 58 |
| Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | sales@win-winchemical.com | China | 14304 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19908 | 58 |
| Sichuan Biosynce Pharmatech Co., Ltd. | +8619950309693 | diane@biosynce.com | China | 4871 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501; +undefined18621343501 | product@acmec-e.com | China | 33324 | 58 |
| Suzhou ARTK Medchem Co., Ltd. | +8618118463618 | sales1@artkmedchem.com | China | 39021 | 58 |
| SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | cooperation@kean-chem.com | China | 40066 | 58 |
| Sinco Pharmachem (ShenZhen) R&D Co., Ltd. | +undefined18603013401 | jack.lin@sincopharmachem.com | China | 9996 | 58 |
220199-85-9(1-N-BOC-MORPHOLINE)Related Search:
1of4
