3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoic Acid
- CAS No.
- 162401-62-9
- Chemical Name:
- 3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoic Acid
- Synonyms
- 3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid;RofluM;Roflumilast Impurity J;Roflumilast Impurity 33;Roflumilast Acid Impurity;Roflumilast intermediate B;RofluMilast InterMediate II;Acid Impurity of Roflumilast;Roflumilast Related Compound D;Roflumilast USP Related Compound D
- CBNumber:
- CB02487690
- Molecular Formula:
- C12H12F2O4
- Molecular Weight:
- 258.22
- MDL Number:
- MFCD04621687
- MOL File:
- 162401-62-9.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzoic acid | MNO000161 | 1g | $114 |
| 3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzoic Acid min. 98.0 % | C3395 | 1G | $89 |
| 3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzoic Acid min. 98.0 % | C3395 | 5G | $267 |
| 3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid Asreported | 269188 | 5g | $425 |
| 3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid Asreported | 269188 | 10g | $602 |
| More product size | |||
| Melting point | 118-120℃ |
|---|---|
| Boiling point | 356.4±37.0 °C(Predicted) |
| Density | 1.355±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 3.87±0.10(Predicted) |
| color | White to Off-White |
| InChI | InChI=1S/C12H12F2O4/c13-12(14)18-9-4-3-8(11(15)16)5-10(9)17-6-7-1-2-7/h3-5,7,12H,1-2,6H2,(H,15,16) |
| InChIKey | IGFDIFLMMLWKKY-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C1=CC=C(OC(F)F)C(OCC2CC2)=C1 |
| CAS DataBase Reference | 162401-62-9 |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301 | |||||||||
| Precautionary statements | P301+P310 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 25 | |||||||||
| Safety Statements | 45 | |||||||||
| RIDADR | 2811 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | Ⅲ | |||||||||
| HS Code | 2918999090 | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
|||||||||
| Hazard Classifications | Acute Tox. 3 Oral | |||||||||
| NFPA 704 |
|
3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoic Acid price More Price(83)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | MNO000161 | 3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzoic acid | 162401-62-9 | 1g | $114 | 2026-04-30 | Buy |
| TCI Chemical | C3395 | 3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzoic Acid min. 98.0 % | 162401-62-9 | 1G | $89 | 2026-04-30 | Buy |
| TCI Chemical | C3395 | 3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzoic Acid min. 98.0 % | 162401-62-9 | 5G | $267 | 2026-04-30 | Buy |
| Usbiological | 269188 | 3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid Asreported | 162401-62-9 | 5g | $425 | 2026-06-03 | Buy |
| Usbiological | 269188 | 3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid Asreported | 162401-62-9 | 10g | $602 | 2026-06-03 | Buy |
3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoic Acid Chemical Properties,Uses,Production
Description
3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoic Acid (DGM) is a pharmaceutical intermediate ingredient used in the preparation of Roflumilast, a selective phosphodiesterase-4 (PDE4) inhibitor approved for the treatment of chronic bronchitis and to reduce the risk of exacerbations in patients with severe chronic obstructive pulmonary disease (COPD).
Uses
An impurity and intermediate in the preparation of selective phosphodiesterase 4 (PDE4) inhibitor, Roflumilast (R639700).
Biological Activity
It was shown that 3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoic Acid (DGM) attenuated transforming growth factor-β1 (TGF-β1)-induced EMT in A549 cells and bleomycin-induced pulmonary fibrosis in rats. DGM treatment suppressed the expression of proteins such as α-SMA, waveform protein and collagen I and other proteins and increased the expression of E-cadherin. Correspondingly, the phosphorylation level of Smad2/3 was significantly reduced after DGM treatment[1].
Synthesis
3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoic Acid is synthesised using 3-cyclopropylmethoxy-4-difluoromethoxybenzaldehyde as raw material by chemical reaction. The specific synthesis steps are as follows:
3-cyclopropylmethoxy-4-difluoromethoxybenzaldehyde (12 g, 50 mmol) and sulfamic acid (7.3 g, 75 mmol) were dissolved in glacial acetic acid (50 ml) and the solution added with a solution of sodium chlorite (8.2 g, 75 mmol) in water (15 ml).
The reaction mixture was stirred at room temperature for 1 hr then water (300 ml) was added so obtaining the precipitation of a solid that was filtered and dried at 40° C. under vacuum (12 g, 48 mmol, 97percent yield).
References
[1] TIANXIAO SUN. Inhibitory Effects of 3-Cyclopropylmethoxy-4-(difluoromethoxy) Benzoic Acid on TGF-β1-Induced Epithelial-Mesenchymal Transformation of In Vitro and Bleomycin-Induced Pulmonary Fibrosis In Vivo.[J]. International Journal of Molecular Sciences, 2023. DOI:10.3390/ijms24076172.
3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoic Acid Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hefei TianRui Pharmaceutical Chemical Co., Ltd. | +86-0551-68665055 +86-+86-18616906106 | sales@trywchem.com | China | 187 | 58 |
| Shanghai Famo Biotech Co Ltd | +86-36680037 +86-18550473860 | mayan@famobiotech.com;sales@famobiotech.com | China | 528 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ | sales03@shyrchem.com | CHINA | 738 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Klong Industrial Co., Ltd | 0086-519-68231162 | info@klongchem.com | CHINA | 131 | 58 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
| Jinan Shengqi pharmaceutical Co,Ltd | 86+18663751872 | christine@shengqipharm.com | CHINA | 491 | 58 |
View Lastest Price from 3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoic Acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-12-05 | 3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid
162401-62-9
|
5kg | 99.99 | 1ton | Hefei TianRui Pharmaceutical Chemical Co., Ltd. | ||
 |
2025-11-24 | 3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoic acid
162401-62-9
|
1kg | 99%min | 100 KGS | Hangzhou Verychem Science And Technology Co.Ltd | ||
 |
2022-02-10 | 3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzoic acid
162401-62-9
|
1KG | 99.1% | 100 tons | Honest Joy Holdings Limited
|
-
- 3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid
162401-62-9
- 99.99
- Hefei TianRui Pharmaceutical Chemical Co., Ltd.
-
- 3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoic acid
162401-62-9
- 99%min
- Hangzhou Verychem Science And Technology Co.Ltd
-
- 3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzoic acid
162401-62-9
- $0.00
- 99.1%
- Honest Joy Holdings Limited
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