ChemicalBook >> CAS DataBase List >>(R)-[3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methyl methanesulfonate
(R)-[3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methyl methanesulfonate
![(R)-[3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methyl methanesulfonate Structure](CAS2/GIF/174649-09-3.gif)
- CAS No.
- 174649-09-3
- Chemical Name:
- (R)-[3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methyl methanesulfonate
- Synonyms
- Linezolid related Compound;Linezolid USP RC D;Unezolld Impurlty 47;Linezolid Impurity 32;Mesylate imp USP RC-D;Linezolid Impurity1318;Linezolid impurity D RS;Linezolid impurity (L-0720);Linezolid Related Compound 1;Linezolid USP Related Compound D
- CBNumber:
- CB02510028
- Molecular Formula:
- C15H19FN2O6S
- Molecular Weight:
- 374.38
- MDL Number:
- MFCD18070719
- MOL File:
- 174649-09-3.mol
- MSDS File:
- SDS
Last updated:2026-05-27 17:25:06
| Product description | Number | Pack Size | Price |
| (R)-3-(3-Fluoro-4-morpholin-4-ylphenyl)-2-oxo-5-oxazolidinyl)methyl methansulfonate | IF58046 | 5g | $188.45 |
| (R)-3-(3-Fluoro-4-morpholin-4-ylphenyl)-2-oxo-5-oxazolidinyl)methyl methansulfonate | IF58046 | 10g | $314.1 |
| (R)-3-(3-Fluoro-4-morpholin-4-ylphenyl)-2-oxo-5-oxazolidinyl)methyl methansulfonate | IF58046 | 25g | $471 |
| (R)-3-(3-Fluoro-4-morpholin-4-ylphenyl)-2-oxo-5-oxazolidinyl)methyl methansulfonate | IF58046 | 50g | $628.5 |
| (R)-3-(3-Fluoro-4-morpholin-4-ylphenyl)-2-oxo-5-oxazolidinyl)methyl methansulfonate | IF58046 | 100g | $865 |
| More product size | |||
| Melting point | 183-185℃ |
|---|---|
| Boiling point | 592.7±50.0 °C(Predicted) |
| Density | 1.418 |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly, Heated), DMSO (Slightly), Methanol (Slightly, Heated) |
| form | Solid |
| pka | 5.71±0.40(Predicted) |
| color | White to Off-White |
| Major Application | pharmaceutical |
| InChI | 1S/C15H19FN2O6S/c1-25(20,21)23-10-12-9-18(15(19)24-12)11-2-3-14(13(16)8-11)17-4-6-22-7-5-17/h2-3,8,12H,4-7,9-10H2,1H3/t12-/m1/s1 |
| InChIKey | UCVIKCGVGWBTTI-GFCCVEGCSA-N |
| SMILES | Fc1c(ccc(c1)N3C[C@@H](OC3=O)CO[S](=O)(=O)C)N2CCOCC2 |
| FDA UNII | D02QUU2JKY |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| WGK Germany | WGK 3 |
| HS Code | 2934990002 |
| Storage Class | 11 - Combustible Solids |
(R)-[3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methyl methanesulfonate price More Price(33)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | IF58046 | (R)-3-(3-Fluoro-4-morpholin-4-ylphenyl)-2-oxo-5-oxazolidinyl)methyl methansulfonate | 174649-09-3 | 5g | $188.45 | 2026-06-04 | Buy |
| Biosynth | IF58046 | (R)-3-(3-Fluoro-4-morpholin-4-ylphenyl)-2-oxo-5-oxazolidinyl)methyl methansulfonate | 174649-09-3 | 10g | $314.1 | 2026-06-04 | Buy |
| Biosynth | IF58046 | (R)-3-(3-Fluoro-4-morpholin-4-ylphenyl)-2-oxo-5-oxazolidinyl)methyl methansulfonate | 174649-09-3 | 25g | $471 | 2026-06-04 | Buy |
| Biosynth | IF58046 | (R)-3-(3-Fluoro-4-morpholin-4-ylphenyl)-2-oxo-5-oxazolidinyl)methyl methansulfonate | 174649-09-3 | 50g | $628.5 | 2026-06-04 | Buy |
| Biosynth | IF58046 | (R)-3-(3-Fluoro-4-morpholin-4-ylphenyl)-2-oxo-5-oxazolidinyl)methyl methansulfonate | 174649-09-3 | 100g | $865 | 2026-06-04 | Buy |
(R)-[3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methyl methanesulfonate Chemical Properties,Uses,Production
Uses
(5R)-3-[3-Fluoro-4-(4-morpholinyl)phenyl]-5-[[(methylsulfonyl)oxy]methyl]-2-oxazolidinone (Linezolid USP Related Compound D) is an intermediate in the synthesis of Linezolid Dimer (L466520), an impurity of the antibacterial agent Linezolid (L466500).
Synthesis
124-63-0
168828-82-8
![(R)-[3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methyl methanesulfonate](/CAS2/GIF/174649-09-3.gif)
174649-09-3
To a 1L solution of dichloromethane containing 132.8 g of (R)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-5-hydroxymethyl-2-oxazolidinone and 87.1 g of triethylamine was slowly added 74 g of methanesulfonyl chloride at 0°C under nitrogen protection. The reaction mixture was stirred at 0 °C for 30 min and then gradually warmed up to room temperature. A white solid precipitated during the reaction. Subsequently, a solvent mixture consisting of 1.75 L of water, 6.50 L of dichloromethane and 1 L of ethyl acetate was added to the reaction system and stirring was continued for 30 minutes. Upon completion of the reaction, the white solid product was collected by filtration. A final product of 140 g was obtained with a yield of 105.42% (w/w).
References
[1] Patent: WO2009/63505, 2009, A2. Location in patent: Page/Page column 14
[2] Patent: EP2163547, 2010, A1. Location in patent: Page/Page column 8
[3] Patent: WO2011/77310, 2011, A1. Location in patent: Page/Page column 12; 13
[4] Synthetic Communications, 2010, vol. 40, # 6, p. 789 - 798
[5] Patent: WO2010/84514, 2010, A2. Location in patent: Page/Page column 15
Synthesis of (R)-[3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methyl methanesulfonate from Methanesulfonyl chloride and (5R)-3-(3-Fluoro-4-(4-morpholinyl)phenyl)-5-hydroxymethyl-2-oxazolidione
(R)-[3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methyl methanesulfonate Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
Global( 170)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | +86-13017695106 +86-13676922317 | jiuyitime@fdachem.com | China | 16512 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| Hi-Tech Chemistry Corp | 0519-86626038 | yuhh@hitechem.com | CHINA | 810 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21587 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| RongNa Biotechnology Co.,Ltd | +86-86-13583358881 +8618560316533 | Brad@rongnabiotech.com | China | 3364 | 58 |
View Lastest Price from (R)-[3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methyl methanesulfonate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
![(R)-[3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methyl methanesulfonate pictures](/ProductImageEN1/2025-04/Small/09724e28-5811-4ebf-82af-e69fc50f297b.gif) |
2026-06-08 | (R)-[3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methyl methanesulfonate
174649-09-3
|
0.99 | RongNa Biotechnology Co.,Ltd | ||||
 |
2026-04-17 | (R)-(3-(3-Fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl methanesulfonate
174649-09-3
|
$2.20-8.80 | 1kg | 99%min | 100kg | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |
![(R)-[3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methyl methanesulfonate pictures](https://img.chemicalbook.com/ProductImageEN/2018-12/Small/41f9657a-0e14-49cd-a395-80d18bba1382.png) |
2019-07-06 | (R)-[3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methyl methanesulfonate
174649-09-3
|
$2.00 | 1kg | 99% | Career Henan Chemical Co |
-
- (R)-[3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methyl methanesulfonate
174649-09-3
- 0.99
- RongNa Biotechnology Co.,Ltd
-
- (R)-(3-(3-Fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl methanesulfonate
174649-09-3
- $2.20-8.80
- 99%min
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- (R)-[3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methyl methanesulfonate
174649-09-3
- $2.00
- 99%
- Career Henan Chemical Co
174649-09-3((R)-[3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methyl methanesulfonate)Related Search:
Linezolid Diphthalimide
Linezolid
(S)-N-((3-(3-fluoro-4-Morpholinophenyl)-2-oxooxazolidin-5-yl)Methyl)ethanethioaMide
(S)-N-(3-Chloro-2-hydroxypropyl)acetamide
4-(2-BROMO-4-NITROPHENYL)MORPHOLINE
(5R)-3-(3-Fluoro-4-(4-morpholinyl)phenyl)-5-hydroxymethyl-2-oxazolidione
(R)-5-(Azidomethyl)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxazolidinone
O-descarbonyl O-Acetyl Linezolid
Linezolid Impurity 34
Linezolid Impurity 11
1of4
(R)-[3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methyl methanesulfonate
(R)-[3-(3-Fluoro-4-Morpholinophenyl)-2-oxo-5-oxazolidinyl]Methyl Methanesulfonat
(R)-(3-(3-flouro-4-Morpholinophenyl)-2-oxo-5-oxazolidinyl)Methyl Methanesulfonate
(R)-(3-(3-Fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl methanesulfonate
(5R)-3-[3-Fluoro-4-(4-Morpholinyl)phenyl]-5-[[(Methylsulfonyl)oxy]Methyl]-2-oxazolidinone
2-Oxazolidinone, 3-[3-fluoro-4-(4-Morpholinyl)phenyl]-5-[[(Methylsulfonyl)oxy]Methyl]-, (5R)-
Linezolid USP RC D
(R)-N-(3-(3-Fluoro-(4-morpholinyl)phenyl)-2-oxo-5-oxazolidinyl)methanol mesylate
Linezolid Impurity 32
(R)-3-(3-Fluoro-4-morpholin-4-ylphenyl)-2-oxo-5-oxazolidinyl)methyl methansulfonate
Linezolid USP Related Compound D
Linezolid Related Compound 1
Mesylate imp USP RC-D
Linezolid Related Compound D (Linezolid Mesylate Impurity)
(R)-[3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]me...
Linezolid Impurity1318
TIANFU-CHEM --(R)-[3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methyl methanesulfonate
Linezolid related Compound
Unezolld Impurlty 47
(R) - N - [3- (3-fluoro - (4-morpholino) phenyl) -2-oxo-5-oxazolyl] methanesulfonate
(R)-Methanesulfonic acid 3-(3-fluoro-4- morpholin-4-yl- phenyl)-2-oxo- oxazolidin-5-ylmethyl
(5R)-[3-(3-Fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl]methyl Methanesulfonate
(R)-N-[3-(3-Fluoro-4-(morpholin-4-yl)phenyl)-2-oxo-5-oxazolidinyl]methanolMethanesulfonate
(R)-(3-(3-FLUORO-4-MORPHOLINOPHENYL)-2- OXOOXAZOLIDIN-5-YL)METHYL METHANESULFONATE / LINEZOLID RELATED
COMPOUND D
Linezolid impurity D RS
(R)-N-[3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methanol methanesulfonate
Linezolid impurity (L-0720)
174649-09-3
185608-75-8
