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ChemicalBook >> CAS DataBase List >>Paramethasone

Paramethasone

CAS No.
53-33-8
Chemical Name:
Paramethasone
Synonyms
Cortiden;PARAMETHASONE;Picaridin Impurity 9;Paramethasone (Standard);6a-Fluoro-16a-methylprednisolone;16a-Methyl-6a-fluoroprednisolone;Halobetasol Propionate Impurity 15;6-alpha-fluoro-16-alpha-methylprednisolone;Methylprednisolone Impurity 30 (Paramethasone);1, 4-PREGNADIEN-6α-FLUORO-16α-METHYL-11β, 17, 21-TRIOL-3, 20-DIONE
CBNumber:
CB0301372
Molecular Formula:
C22H29FO5
Molecular Weight:
392.46
MDL Number:
MFCD03695621
MOL File:
53-33-8.mol
MSDS File:
SDS
Last updated:2023-05-04 17:34:39
Product description Number Pack Size Price
Paramethasone >95%(HPLC) TRC-P191840-25MG 25mg $2468
Paramethasone >95%(HPLC) TRC-P191840-2.5MG 2.5mg $292
Paramethasone FP100930 1mg $900
Paramethasone FP100930 5mg $1178.75
Paramethasone FP100930 10mg $1886
More product size

Paramethasone Properties

Melting point 228-241°C
Boiling point 573.5±50.0 °C(Predicted)
Density 1.32±0.1 g/cm3(Predicted)
storage temp. -20°C Freezer
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka 12.34±0.70(Predicted)
color White to Pale Beige
CAS DataBase Reference 53-33-8
FDA UNII VFC6ZX3584
ATC code H02AB05

SAFETY

Risk and Safety Statements

Hazardous Substances Data 53-33-8(Hazardous Substances Data)

Paramethasone price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC TRC-P191840-25MG Paramethasone >95%(HPLC) 53-33-8 25mg $2468 2026-06-03 Buy
TRC TRC-P191840-2.5MG Paramethasone >95%(HPLC) 53-33-8 2.5mg $292 2026-06-03 Buy
Biosynth FP100930 Paramethasone 53-33-8 1mg $900 2026-06-04 Buy
Biosynth FP100930 Paramethasone 53-33-8 5mg $1178.75 2026-06-04 Buy
Biosynth FP100930 Paramethasone 53-33-8 10mg $1886 2026-06-04 Buy
Product number Packaging Price Buy
TRC-P191840-25MG 25mg $2468 Buy
TRC-P191840-2.5MG 2.5mg $292 Buy
FP100930 1mg $900 Buy
FP100930 5mg $1178.75 Buy
FP100930 10mg $1886 Buy

Paramethasone Chemical Properties,Uses,Production

Originator

Haldrone,Lilly,US,1961

Uses

Paramethasone, is a fluorinated glucocorticoid, having anti-inflammatory and immunosuppressant properties.

Uses

Glucocorticoid.

Definition

ChEBI: Paramethasone is a fluorinated steroid.

Manufacturing Process

A solution of 0.144 g of the 3-ethylene glycol ketal of 5α,11β,17α,21 tetrahydroxy-6β-fluoro-16α-methylallopregnane-3,20-dione-21 acetate in 12 ml of chloroform and 0.1 ml of absolute alcohol was cooled to -10°C in an icesalt bath and a stream of anhydrous hydrochloric acid was gently bubbled through the solution for 2.5 hours while the temperature was maintained between -5°C and -15°C. The solution was then diluted with 25 ml of chloroform, washed with dilute sodium bicarbonate and water, dried over anhydrous sodium sulfate, and evaporated to dryness under reduced pressure at 60°C or less to give 6α-fluoro-11β,17α,21-trihydroxy-16α-methyl-4-pregnene3,20-dione 21-acetate.

brand name

Haldrone (Lilly).

Therapeutic Function

Glucocorticoid

Paramethasone Preparation Products And Raw materials

Raw materials

Preparation Products

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16a-Methyl-6a-fluoroprednisolone 6a-Fluoro-16a-methylprednisolone Cortiden Pregna-1,4-diene-3,20-dione, 6a-fluoro-11b,17,21-trihydroxy-16a-methyl- (8CI) Pregna-1,4-diene-3,20-dione, 6a-fluoro-11b,17,21-trihydroxy-16-methyl- (7CI) Pregna-1,4-diene-3,20-dione, 6-fluoro-11,17,21-trihydroxy-16-methyl-, (6a,11b,16a)- (9CI) (6S,8S,9S,10R,11S,13S,14S,16R,17R)-6-Fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one 6α-Fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione PARAMETHASONE 6a-fluoro-11b,17a,21-trihydroxy-16a-methyl-1,4-pregnadiene-3,20-dione 6-alpha-fluoro-11-beta,17-alpha,21-trihydroxy-16-alpha-methylpregna-1,4-diene-3,20-dione 6-alpha-fluoro-16-alpha-methylprednisolone 1,4-PREGNADIEN-6-ALPHA-FLUORO-16-ALPHA-METHYL-11-BETA, 17,21-TRIOL-3,20-DIONE (6S,8S,9S,10R,11S,13S,14S,16R,17R)-6-fluoro-11,17-dihydroxy-17-(2-hydroxyethanoyl)-10,13,16-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one (6S,8S,9S,10R,11S,13S,14S,16R,17R)-6-fluoro-17-glycoloyl-11,17-dihydroxy-10,13,16-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one 6-fluoro-11,17-dihydroxy-17-(2-hydroxy-1-oxoethyl)-10,13,16-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one Pregna-1,4-diene-3,20-dione, 6-fluoro-11,17,21-trihydroxy-16-methyl-, (6α,11β,16α)- Pregna-1,4-diene-3,20-dione,6-fluoro-11,17,21-trihydroxy-16-methyl-, (6a,11b,16a)- Methylprednisolone Impurity 30 (Paramethasone) 1, 4-PREGNADIEN-6α-FLUORO-16α-METHYL-11β, 17, 21-TRIOL-3, 20-DIONE Picaridin Impurity 9 Halobetasol Propionate Impurity 15 Paramethasone (Standard) 53-33-8
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