METHYL 2-AMINO-4-THIAZOLEACETATE
- CAS No.
- 64987-16-2
- Chemical Name:
- METHYL 2-AMINO-4-THIAZOLEACETATE
- Synonyms
- Methyl 2-(2-aMinothiazol-4-yl)acetate;METHYL 2-AMINO-4-THIAZOLEACETATE;METHYL 2-AMINOTHIAZOLE-4-ACETATE;Methyl 2-aMinothiazol-4-yl-acetate;METHYL (2-AMINO-4-THIAZOLYL)ACETATE;Methyl 2-amino-4-thiazoleacetate 98%;methyl (2-amino-1,3-thiazol-4-yl)acetate;METHYL 2-(2-AMINO-1,3-THIAZOL-4-YL)ACETATE;2-AMino-4-thiazoleacetic acid Methyl ester;2-Amino-4-(methylcarboxymethyl)-1,3-thiazole
- CBNumber:
- CB0342179
- Molecular Formula:
- C6H8N2O2S
- Molecular Weight:
- 172.2
- MDL Number:
- MFCD00129969
- MOL File:
- 64987-16-2.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Methyl 2-amino-4-thiazoleacetate 98% | 649724 | 5g | $361 |
| Methyl 2-amino-4-thiazoleacetate 98% | 649724 | 1g | $92.8 |
| Methyl 2-(2-amino-1,3-thiazol-4-yl)acetate | 045465 | 500.00mg | $118 |
| Methyl 2-(2-amino-1,3-thiazol-4-yl)acetate | 045465 | 1.00g | $151 |
| Methyl 2-(2-amino-1,3-thiazol-4-yl)acetate | 045465 | 5.00g | $346 |
| More product size | |||
| Melting point | 112-116 °C(lit.) |
|---|---|
| Boiling point | 307.3±17.0 °C(Predicted) |
| Density | 1.353±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| form | solid |
| pka | 3.61±0.10(Predicted) |
| Appearance | Light yellow to light brown Solid |
| InChI | InChI=1S/C6H8N2O2S/c1-10-5(9)2-4-3-11-6(7)8-4/h3H,2H2,1H3,(H2,7,8) |
| InChIKey | XTQKFBGFHDNUFY-UHFFFAOYSA-N |
| SMILES | S1C=C(CC(OC)=O)N=C1N |
| CAS DataBase Reference | 64987-16-2 |
| UNSPSC Code | 12352100 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|---|---|
| Signal word | Danger |
| Hazard statements | H315-H318-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
| target organs | Respiratory system |
| PPE | dust mask type N95 (US), Eyeshields, Gloves |
| Hazard Codes | Xi |
| Risk Statements | 37/38-41 |
| Safety Statements | 26-39 |
| WGK Germany | 3 |
| HazardClass | IRRITANT |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Eye Dam. 1 Skin Irrit. 2 STOT SE 3 |
METHYL 2-AMINO-4-THIAZOLEACETATE price More Price(59)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 649724 | Methyl 2-amino-4-thiazoleacetate 98% | 64987-16-2 | 5g | $361 | 2023-06-20 | Buy |
| Sigma-Aldrich | 649724 | Methyl 2-amino-4-thiazoleacetate 98% | 64987-16-2 | 1g | $92.8 | 2022-05-15 | Buy |
| Matrix Scientific | 045465 | Methyl 2-(2-amino-1,3-thiazol-4-yl)acetate | 64987-16-2 | 500.00mg | $118 | 2026-05-18 | Buy |
| Matrix Scientific | 045465 | Methyl 2-(2-amino-1,3-thiazol-4-yl)acetate | 64987-16-2 | 1.00g | $151 | 2026-05-18 | Buy |
| Matrix Scientific | 045465 | Methyl 2-(2-amino-1,3-thiazol-4-yl)acetate | 64987-16-2 | 5.00g | $346 | 2026-05-18 | Buy |
METHYL 2-AMINO-4-THIAZOLEACETATE Chemical Properties,Uses,Production
Uses
Methyl 2-Amino-4-thiazoleacetate is a reactant in the preparation of N-[4-(substituted)-1,3-thiazol-2-yl]-2-(substituted)acetamides as antibacterial agents against S. aureus, E. coli, P. aeruginosa, and K. pneumonia.
Synthesis
67-56-1
29676-71-9
64987-16-2
General procedure for the synthesis of methyl 2-(2-aminothiazol-4-yl)acetate from methanol and 2-aminothiazole-4-acetic acid: to a solution of 2-amino-4-thiazoleacetic acid (20 g, 0.126 mol) in methanol (100 ml) was added slowly and dropwise to concentrated H2SO4 (24 ml) at 0-5 °C. The reaction mixture was heated to reflux for 5 hours. After completion of the reaction, the pH of the reaction mixture was adjusted to 8-9 with NaHCO3 solution, when a colorless precipitate was produced. The precipitate was collected by filtration and dried to give 19.5 g of methyl 2-(2-aminothiazol-4-yl)acetate in 93% yield.
References
[1] Patent: US2010/152188, 2010, A1. Location in patent: Page/Page column 6
[2] Patent: WO2007/17728, 2007, A2. Location in patent: Page/Page column 15
[3] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 18, p. 5408 - 5412
[4] Bioorganic and Medicinal Chemistry, 2017, vol. 25, # 1, p. 338 - 349
[5] Synthetic Communications, 2003, vol. 33, # 12, p. 1977 - 1995
METHYL 2-AMINO-4-THIAZOLEACETATE Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| AFINE CHEMICALS LIMITED | +86-571-85134551 | info@afinechem.com | China | 15083 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52704 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25356 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +86-571-86217390; +8618058761490 | info@gihichemicals.com | China | 49962 | 58 |
| Xuzhou B&C Chemical Technology Co., Ltd | +86-400-0516-021 +8617855106283 | info@bcpharma.com | China | 2732 | 58 |
| SUZHOU SENFEIDA CHEMICAL CO.,LTD | +86-0512-83500002 +8618662433356 | 3899766280@qq.com | China | 26362 | 58 |
View Lastest Price from METHYL 2-AMINO-4-THIAZOLEACETATE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-12-20 | METHYL 2-AMINO-4-THIAZOLEACETATE
64987-16-2
|
$1.00 | 100g | 99% | Career Henan Chemical Co |
-
- METHYL 2-AMINO-4-THIAZOLEACETATE
64987-16-2
- $1.00
- 99%
- Career Henan Chemical Co
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