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Roscovitine

Roscovitine structure

CAS No.: 186692-46-6

Chemical Name:: Roscovitine

Synonyms: Seliciclib;Roscovitin;Roscovitine (Seliciclib,CYC202);CYC 202;Posiphe;CS-1845;P34 CDC2;ROSCOVITINE;Roscoviline;(R)-2-(1-ETHY

CBNumber:: CB0367185

Molecular Formula:: C19H26N6O

Molecular Weight:: 354.45

MDL Number:: MFCD02266401

MOL File:: 186692-46-6.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-07-14 16:49:18

Product description	Number	Pack Size	Price
Roscovitine	557360	1mg	$78.3
Roscovitine InSolution, ≥95%, inhibitor of cyclin-dependent kinases (CDKs)	557364	5mg	$242
Roscovitine	557360	5mg	$299
Roscovitine	R0207	20MG	$106
(R)-Roscovitine ≥98%	10009569	500μg	$25
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Roscovitine Properties

Melting point	106～107℃
Boiling point	577.5±60.0 °C(Predicted)
Density	1.3
storage temp.	-20°C
solubility	Soluble in DMSO (up to 10 mg/ml, with warming) or in Ethanol (up to 10 mg/ml).
form	White to off-white solid
pka	14.56±0.10(Predicted)
color	White
biological source	synthetic (organic)
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChI	InChI=1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1
InChIKey	BTIHMVBBUGXLCJ-OAHLLOKOSA-N
SMILES	C(O)[C@H](NC1=NC(NCC2=CC=CC=C2)=C2C(=N1)N(C(C)C)C=N2)CC
CAS DataBase Reference	186692-46-6(CAS DataBase Reference)
FDA UNII	0ES1C2KQ94
NCI Drug Dictionary	seliciclib
UNSPSC Code	12352202
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302+H312+H332-H315-H319
Precautionary statements	P501-P261-P270-P271-P264-P280-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330-P302+P352+P312-P304+P340+P312
PPE	Eyeshields, Gloves, type N95 (US)
Safety Statements	22-24/25
WGK Germany	3
HS Code	29335990
Storage Class	11 - Combustible Solids

Roscovitine price More Price(122)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	557360	Roscovitine	186692-46-6	1mg	$78.3	2026-04-30	Buy
Sigma-Aldrich	557364	Roscovitine InSolution, ≥95%, inhibitor of cyclin-dependent kinases (CDKs)		5mg	$242	2026-04-30	Buy
Sigma-Aldrich	557360	Roscovitine	186692-46-6	5mg	$299	2026-04-30	Buy
TCI Chemical	R0207	Roscovitine	186692-46-6	20MG	$106	2026-04-30	Buy
Cayman Chemical	10009569	(R)-Roscovitine ≥98%	186692-46-6	500μg	$25	2026-04-30	Buy

Product number	Packaging	Price	Buy
557360	1mg	$78.3	Buy
557364	5mg	$242	Buy
557360	5mg	$299	Buy
R0207	20MG	$106	Buy
10009569	500μg	$25	Buy

Roscovitine Chemical Properties,Uses,Production

Description

Roscovitine (186692-46-6) is a potent and selective inhibitor of cyclin-dependent kinases displaying higher potency and selectivity compared to olomoucine. p34 cdc2 IC50 = 0.2 μM. Also inhibits p33cdk2 and p33cdk5.1 Anti-angiogenic.2 Prevents PPARg S273 phosphorylation, promoting browning of white adipose tissue.3 Enhances peripheral nerve regrowth.4

Uses

Roscovitine is a potent and selective inhibitor of cyclin-dependent kinases (CDKs). Roscovitine has been found to produce apoptosis in treated cancerous cells of non-small cell lung cancer (NSCLC) and other cancers. Studies show that Roscovitine displays increased anti-mitotic activity at the G1/S and G2/M phases of the cell cycle. Roscovitine maybe useful in the treatment of non-small cell lung cancer (NSCLC), leukemia, HIV infection, herpes simplex infection, and the mechanisms of chronic inflammation disorders.

Definition

ChEBI: 2,6-Diaminopurine carrying benzylamino, (2R)-1-hydroxybutan-2-yl and isopropyl substituents at C-6, C-2-N and N-9 respectively. It is an experimental drug candidate in the family of pharmacological cyclin-dependent kinase (CDK) inhibitors.

General Description

A potent, reversible, and selective inhibitor of cyclin-dependent kinases (Cdks) that exhibits about ten-fold greater efficacy towards p34^cdk1 and p33^cdk2 and twenty-fold greater efficacy towards p33^cdk5 relative to Olomoucine (Cat. No. 495620). Inhibits p34^cdk1/cyclin B (IC₅₀ = 650 nM), p33^cdk2/cyclin A (IC₅₀ = 700 nM), p33^cdk2/cyclin E (IC₅₀ = 700 nM), and p33^cdk5/p35 (IC₅₀ = 200 nM) by competing for the ATP binding domain of the kinases. Exhibits reduced sensitivity towards related kinases including ERK1 and ERK2 (IC₅₀ = 34 μM and 14 μM, respectively). Roscovitine does not significantly affect the activity of other protein kinases even at 100 μM, including p34^cdk4/cyclin D1 and p40^cdk6/cyclin D2. Compared to olomoucine, roscovitine displays increased anti-mitotic activity at the G₁/S and G₂/M phases of the cell cycle. A 50 mM (5 mg/282 μl) solution of Roscovitine (Cat. No. 557364) in DMSO is also available.

Biochem/physiol Actions

Roscovitine is a purine derived inhibitor. It stimulates apoptosis in cancer cells. It has inhibitory action on mitogen activated protein kinase (MAPK) and M-phase promoting factor (MPF) kinase activity. Roscovitine is known to arrest meiosis and thus, prevent embryonic development.

Anticancer Research

Roscovitine a derivative of olomoucine which is isolated from Raphanus sativus isunder clinical trials (Shoeb 2006).

storage

Store at -20°C

References

[1] LAURENT MEIJER. Biochemical and Cellular Effects of Roscovitine, a Potent and Selective Inhibitor of the Cyclin-Dependent Kinases cdc2, cdk2 and cdk5[J]. The FEBS journal, 2004, 243 1-2: 527-536. DOI:10.1111/j.1432-1033.1997.t01-2-00527.x
[2] JOHANNA LIEBL. Anti-angiogenic effects of purine inhibitors of cyclin dependent kinases[J]. Angiogenesis, 2011, 14 3: 281-291. DOI:10.1007/s10456-011-9212-6
[3] HONG WANG. Browning of White Adipose Tissue with Roscovitine Induces a Distinct Population of UCP1+ Adipocytes.[J]. Cell metabolism, 2016, 24 6 1: 835-847. DOI:10.1016/j.cmet.2016.10.005
[4] V. LAW. Enhancement of Peripheral Nerve Regrowth by the Purine Nucleoside Analog and Cell Cycle Inhibitor, Roscovitine[J]. Frontiers in Cellular Neuroscience, 2016, 10 1. DOI:10.3389/fncel.2016.00238

Roscovitine Preparation Products And Raw materials

Raw materials

Preparation Products

Roscovitine Suppliers

Global( 267)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29812	58
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	965	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32466	58
Shanghai Gubang New Materail Technology Co. LTD	21-51317962 +8618721305404	16728589@qq.com	CHINA	272	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6312	58
Dideu Industries Group Limited	+86-86-15536356810 +8617392712697	1022@dideu.com	China	29095	58
Finetech Industry Limited	+86-27-8746-5837 +8619945049750	info@finetechnology-ind.com	China	9539	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Biochempartner	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
TargetMol Chemicals Inc.	58
Shanghai Gubang New Materail Technology Co. LTD	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Dideu Industries Group Limited	58
Finetech Industry Limited	58

Roscovitine: Overview and Preclinical Studies
Roscovitine, a potent CDK inhibitor, shows promising anticancer effects and therapeutic potential in kidney diseases and infla....
Apr 17，2024

A CDK small molecule inhibitor——Roscovitine
Roscovitine is a widely used inhibitor in both basic research and disease research. This drug displays anti-inflammatory prope....
Oct 27，2023

View Lastest Price from Roscovitine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-07-14	Seliciclib 186692-46-6	$40.00-102.00		97.15%	10g	TargetMol Chemicals Inc.
2021-08-12	ROSCOVITINE 186692-46-6	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd
2019-09-06	ROSCOVITINE 186692-46-6	$1.00	1KG	98%	20kg	Career Henan Chemical Co

Seliciclib
186692-46-6
$40.00-102.00
97.15%
TargetMol Chemicals Inc.

ROSCOVITINE
186692-46-6
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

ROSCOVITINE
186692-46-6
$1.00
98%
Career Henan Chemical Co

Roscovitine Spectrum

ROSCOVITINE(186692-46-6)¹HNMR

186692-46-6(Roscovitine)Related Search:

1-[[4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]-2-propanol Selumetinib Alisertib (MLN8237) Dasatinib PD 0332991 HCl

(2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol PD0332991 Isethionate BML-259 NS-398 Roscovitine

SELICICLIB (S)-ROSCOVITINE S-ROSCOVITINE 98% (HPLC),ROSCOVITINE, (S)-ISOMER,(S)-ROSCOVITINE RS-ROSCOVITINE 98% (HPLC) (R)-ROSCOVITINE, >95%

ROSCOVITINE, IMMOBILIZED OLOMOUCINE II ROSCOVITINE, 99+%

1of4

2-(R)-[[9-(1-Methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol, 6-(Benzylamino)-2(R)-[[1-(hydroxymethyl)propyl]amino]-9-isopropylpurine (2R)-2-[[6-(benzylamino)-9-propan-2-yl-purin-2-yl]amino]butan-1-ol 2-(R)-(1-ETHYL-2-HYDROXYETHYLAMINO)-6-BENZYLAMINO-9-ISOPROPYLPURINE 2-(1-ETHYL-2-HYDROXYETHYLAMINO)-6-BENZYLAMINO-9-ISOPROPYLPURINE 6-BENZYLAMINO-2-(R)-[(1-ETHYL)-2-HYDROXYETHYLAMINO]-9-ISOPROPYLPURINE ROSCOVITINE (R)-ROSCOVITINE (R)-2-(1-ETHYL-2-HYDROXYETHYLAMINO)-6-BENZYLAMINO-9-ISOPROPYLPURINE P34 CDC2 R-ROSCOVITINE 98% (HPLC) ROSCOVITINE 95+% 1-Butanol, 2-[[9-(1-methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-, (2R)- 2-(r)-[[9-(1-methylethyl)-6-[(phenylmethyl)amino]-9h-purin-2-yl]amino]-1-butanol 6-(Benzylamino)-2(R)-[[1-(hydroxymethyl)propyl]amino]-9-isopropylpurine Roscovitine (CYC202,Seliciclib) 6-Benzylamino-2[(R)-(1'-ethyl-2'-hydroxyethylamino)]-9-isopropylpurine Roscovitine Roscovitine,2-(R)-[[9-(1-Methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol, 6-(Benzylamino)-2(R)-[[1-(hydroxymethyl)propyl]amino]-9-isopropylpurine Roscovitine(CYC202) 2-[[9-(1-Methylethyl)-6-[(phenylMethyl)aMino]-9H-purin-2-yl]aMino]- (R)-2-(1-ETHY Roscovitine (Seliciclib) (2R)-2-[[9-(1-Methylethyl)-6-[(phenylMethyl)aMino]-9H-purin-2-yl]aMino]-1-butanol (R)-2-[[9-(1-Methylethyl)-6-[(phenylMethyl)aMino]-9H-purin-2-yl]aMino]-1-butanol CYC 202 Roscoviline Posiphe CYC-202(ROSCOVITINE) 6-(Benzylamino)-2(R)-[[1-(hydroxymethyl)propyl]amino]-9-isopropylpurine Roscovitine 6-(Benzylamino)-2(R)-[[1-(hydroxymethyl)propyl]amino]-9-isopropylpurine Roscovitine (Seliciclib,CYC202) Roscovitine (R)-Roscovitine Roscovitine, >=98% Roscovitine - CAS 186692-46-6 - Calbiochem CS-1845 SELICICLIB (ROSCOVITINE) CYC202;R-ROSCOVITINE;SELICICLIB 2-(6-Benzylamino-9-isopropyl-9H-purin-2-ylamino)-butan-1-ol （CYC202) ROSCOVITINE USP/EP/BP Seliciclib-d7 Roscovitin Roscovitine (Seliciclib,CYC202) Roscovitine, CDK inhibitor Seliciclib, 10 mM in DMSO Roscovitine >=98% (TLC) (R)-2-((6-(benzylamino)-9-isopropyl-9H-purine-2-yl)amino)butyl-1-ol (R)-2-[[6-(Benzylamino)-9-isopropyl-9H-purin-2-yl]amino]-1-butanol Seliciclib 186692-46-6 Cell Signaling and Neuroscience Cell Cycle Cell Cycle Regulators Cell Biology BioChemical Apoptosis and Cell Cycle Inhibitors Apis API intermediates

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