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ChemicalBook >> CAS DataBase List >>2-Isopropyl-4-(methylaminomethyl)thiazole

2-Isopropyl-4-(methylaminomethyl)thiazole

CAS No.
154212-60-9
Chemical Name:
2-Isopropyl-4-(methylaminomethyl)thiazole
Synonyms
2-ISOPROPYL-4-(METHYLAMINOMETHYL)THIAZOLE;N-Methyl-2-isopropyl-4-thiazoleMethylaMine;2-isopropyl-4-(N-methyl)aminomethylthiazole;(2-isopropylthiazol-4-yl)-N-methylmethanamine;1-(2-Isopropyl-4-thiazolyl)-N-methylmethanamine;1-(2-Isopropylthiazol-4-yl)-N-methyl methanamine;N-methyl-1-(2-propan-2-yl-4-thiazolyl)methanamine;4-Thiazolemethanamine, N-methyl-2-(1-methylethyl)-;N-methyl-(2-isopropyl-1,3-thiazol-4-yl)methylamine;1-(2-isopropyl-1,3-thiazol-4-yl)-N-MethylMethanaMine
CBNumber:
CB0434553
Molecular Formula:
C8H14N2S
Molecular Weight:
170.28
MDL Number:
MFCD06797969
MOL File:
154212-60-9.mol
MSDS File:
SDS
Last updated:2026-05-27 22:41:21
Product description Number Pack Size Price
2-Isopropyl-4-(methylaminomethyl)thiazole Asreported 280287 100mg $644
2-Isopropyl-4-(methylaminomethyl)thiazole Asreported 280287 250mg $970
2-Isopropyl-4-(methylaminomethyl)thiazole Asreported 280287 500mg $1351
2-Isopropyl-4-(methylaminomethyl)thiazole Asreported 280287 1g $1848
2-Isopropyl-4-(methylaminomethyl)thiazole Asreported 280287 2g $2654
More product size

2-Isopropyl-4-(methylaminomethyl)thiazole Properties

Boiling point 230.9±15.0 °C(Predicted)
Density 1.039±0.06 g/cm3(Predicted)
storage temp. 2-8°C, protect from light
pka 8.06±0.10(Predicted)
Appearance Colorless to light yellow Liquid
InChI InChI=1S/C8H14N2S/c1-6(2)8-10-7(4-9-3)5-11-8/h5-6,9H,4H2,1-3H3
InChIKey HWSFABGWAXURNG-UHFFFAOYSA-N
SMILES S1C=C(CNC)N=C1C(C)C
CAS DataBase Reference 154212-60-9(CAS DataBase Reference)
EWG's Food Scores 1-2
FDA UNII G297848J78

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H319
Precautionary statements  P305+P351+P338
Hazard Codes  Xn,N
Risk Statements  21/22-38-41-51/53
Safety Statements  26-36/37/39-61
HS Code  2934100090
REACH Registrations Inactive

2-Isopropyl-4-(methylaminomethyl)thiazole price More Price(52)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological 280287 2-Isopropyl-4-(methylaminomethyl)thiazole Asreported 154212-60-9 100mg $644 2026-06-03 Buy
Usbiological 280287 2-Isopropyl-4-(methylaminomethyl)thiazole Asreported 154212-60-9 250mg $970 2026-06-03 Buy
Usbiological 280287 2-Isopropyl-4-(methylaminomethyl)thiazole Asreported 154212-60-9 500mg $1351 2026-06-03 Buy
Usbiological 280287 2-Isopropyl-4-(methylaminomethyl)thiazole Asreported 154212-60-9 1g $1848 2026-06-03 Buy
Usbiological 280287 2-Isopropyl-4-(methylaminomethyl)thiazole Asreported 154212-60-9 2g $2654 2026-06-03 Buy
Product number Packaging Price Buy
280287 100mg $644 Buy
280287 250mg $970 Buy
280287 500mg $1351 Buy
280287 1g $1848 Buy
280287 2g $2654 Buy

2-Isopropyl-4-(methylaminomethyl)thiazole Chemical Properties,Uses,Production

Uses

2-Isopropyl-4-(methylaminomethyl)thiazole is mainly used as a fine Chemical and intermediate.

Pharmaceutical Applications

Ritonavir is human immunodeficiency virus -1 (HIV-1) and human immunodeficiency virus -2 (HIV-2) aspartic acid egg Oral effective inhibitor of white enzyme, which can slow down sprawlings of the HIV in cell. When synthesizing Ritonavir, the intermediate of Ritonavir, 2-Isopropyl-4-(methylaminomethyl)thiazole, need to be made in advance.

Synthesis

5-CHLOROMETHYL-2-ISOPROPYL-THIAZOLE

40516-57-2

Methylamine

74-89-5

2-Isopropyl-4-(methylaminomethyl)thiazole

154212-60-9

To a 250 mL three-necked flask was added 4-(chloromethyl)-2-isopropylthiazole (9 g, 0.05 mol) and 40% aqueous methylamine solution (100 mL). The reaction mixture was heated to 50-60 °C and the reaction was stirred at this temperature overnight. After the reaction was completed, the mixture was cooled to room temperature. Dichloromethane (100 mL) and isopropanol (30 mL) were added to the reaction mixture, which was stirred thoroughly and left to stratify. The aqueous phase was separated and the aqueous phase was extracted with dichloromethane 3 times. All organic phases were combined and dried with anhydrous sodium sulfate. The dried organic phase was filtered and the filtrate was concentrated under reduced pressure to remove the solvent. The crude product was purified by column chromatography (silica gel, appropriate eluent) to afford 2-isopropyl-4-(methylaminomethyl)thiazole (6.5 g, 74% yield) as a colorless liquid.

References

[1] Patent: CN104557763, 2017, B. Location in patent: Paragraph 0026; 0034; 0035; 0036; 0046; 0056; 0064-0066
[2] Patent: WO2006/90270, 2006, A1. Location in patent: Page/Page column 8-9

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View Lastest Price from 2-Isopropyl-4-(methylaminomethyl)thiazole manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Isopropyl-4-(methylaminomethyl)thiazole pictures 2024-02-21 2-Isopropyl-4-(methylaminomethyl)thiazole
154212-60-9
 $800.00 1g 98 500 Kg R&D Scientific Inc.
2-Isopropyl-4-(methylaminomethyl)thiazole pictures 2021-08-12 2-Isopropyl-4-(methylaminomethyl)thiazole
154212-60-9
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd
2-Isopropyl-4-(methylaminomethyl)thiazole pictures 2021-07-13 2-Isopropyl-4-(methylaminomethyl)thiazole
154212-60-9
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd

2-Isopropyl-4-(methylaminomethyl)thiazole Spectrum

N-Methyl-2-isopropyl-4-thiazoleMethylaMine 2-isopropyl-4-(N-methyl)aminomethylthiazole N-methyl-1-(2-propan-2-yl-1,3-thiazol-4-yl)methanamine 2-ISOPROPYL-4-(METHYLAMINOMETHYL)THIAZOLE 1-(2-Isopropylthiazol-4-yl)-N-methyl methanamine 2-isopropyl-1,3-thiazol-4-methylmethanamine hydrochloride 2-Isopropyl-4-(Methylaminomethyl)Thiazole(IntermediateOfRitonavir) N-methyl-(2-isopropyl-1,3-thiazol-4-yl)methylamine 4-Thiazolemethanamine, N-methyl-2-(1-methylethyl)- 1-(2-isopropyl-1,3-thiazol-4-yl)-N-methylmethanamine(SALTDATA: 2HCl 0.4H2O 0.01S8) 1-(2-isopropyl-1,3-thiazol-4-yl)-N-MethylMethanaMine [(2-Isopropyl-1,3-thiazol-4-yl)Methyl]MethylaMine 2HCl 2-Isopropil-4-(Methylaminomethyl) Thiazole(Ritonavir Intermediate) (2-isopropylthiazol-4-yl)-N-methylmethanamine 1-(2-Isopropyl-4-thiazolyl)-N-methylmethanamine N-methyl-1-(2-propan-2-yl-4-thiazolyl)methanamine N-Methyl-N-[(2-isopropyl]-4-thiazolyl)methyl)amine hydrochloride 2-Isopropyl-4-(Methyl Amino Methyl) Thiazole (MTV-II) 154212-60-9 54212-60-9 C8H14N2S
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