1,4-BIS(N-BOC)PIPERAZINE-2-CARBOXYLIC ACID
- CAS No.
- 181955-79-3
- Chemical Name:
- 1,4-BIS(N-BOC)PIPERAZINE-2-CARBOXYLIC ACID
- Synonyms
- Piperazine-1,2,4-tricarboxylic acid 1,4-di-tert-butyl ester;1,4-Bis(N-boc)piperazine-2-carboxylicaci;1,4-Bis(Boc)-2-piperazinecarboxylic Acid;1,4-bis-Boc-piperazine-2-carboxylic acid;1,4-BIS(N-BOC)PIPERAZINE-2-CARBOXYLIC ACID;1,4-Di-Boc-piperazine-2-carboxylic acid 97%;1-N-Boc-4-N-Boc-piperazine-2-carboxylic acid;1,4-DI-BOC-PIPERAZINE-2-(+/-)-CARBOXYLIC ACID;1,4-Di-Boc-piperazine-2-carboxylic acid, 97.5%;1,2,4-Piperazinetricarboxylic acid 1,4-bis(tert-butyl) ester
- CBNumber:
- CB0443847
- Molecular Formula:
- C15H26N2O6
- Molecular Weight:
- 330.38
- MDL Number:
- MFCD02179115
- MOL File:
- 181955-79-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 1,4-Di-Boc-piperazine-2-carboxylic acid 97% | 756350 | 1g | $284 |
| 1-N-BOC-4-N-BOC-PIPERAZINE-2-CARBOXYLIC ACID 97% | 56369 | 1G | $10 |
| 1-N-BOC-4-N-BOC-PIPERAZINE-2-CARBOXYLIC ACID 97% | 56369 | 5G | $24 |
| 1-N-BOC-4-N-BOC-PIPERAZINE-2-CARBOXYLIC ACID 97% | 56369 | 25G | $67 |
| 1,4-Di-Boc-piperazine-2-carboxylic acid | 075826 | 1.00g | $278 |
| More product size | |||
| Melting point | 142-148°C |
|---|---|
| Boiling point | 443.9±40.0 °C(Predicted) |
| Density | 1.200±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| pka | 3.70±0.20(Predicted) |
| form | solid |
| Appearance | White to off-white Solid |
| InChI | 1S/C15H26N2O6/c1-14(2,3)22-12(20)16-7-8-17(10(9-16)11(18)19)13(21)23-15(4,5)6/h10H,7-9H2,1-6H3,(H,18,19) |
| InChIKey | IIZGWFQKLVCLLA-UHFFFAOYSA-N |
| SMILES | CC(C)(C)OC(=O)N1CCN(C(C1)C(O)=O)C(=O)OC(C)(C)C |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H317-H319 |
| Precautionary statements | P280-P302+P352-P305+P351+P338 |
| Hazard Codes | Xi |
| Risk Statements | 36-43 |
| Safety Statements | 26-36/37 |
| WGK Germany | 3 |
| HS Code | 29335990 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Eye Irrit. 2 Skin Sens. 1 |
1,4-BIS(N-BOC)PIPERAZINE-2-CARBOXYLIC ACID price More Price(47)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 756350 | 1,4-Di-Boc-piperazine-2-carboxylic acid 97% | 181955-79-3 | 1g | $284 | 2026-04-30 | Buy |
| AstaTech | 56369 | 1-N-BOC-4-N-BOC-PIPERAZINE-2-CARBOXYLIC ACID 97% | 181955-79-3 | 1G | $10 | 2026-04-30 | Buy |
| AstaTech | 56369 | 1-N-BOC-4-N-BOC-PIPERAZINE-2-CARBOXYLIC ACID 97% | 181955-79-3 | 5G | $24 | 2026-04-30 | Buy |
| AstaTech | 56369 | 1-N-BOC-4-N-BOC-PIPERAZINE-2-CARBOXYLIC ACID 97% | 181955-79-3 | 25G | $67 | 2026-04-30 | Buy |
| Matrix Scientific | 075826 | 1,4-Di-Boc-piperazine-2-carboxylic acid | 181955-79-3 | 1.00g | $278 | 2026-05-18 | Buy |
1,4-BIS(N-BOC)PIPERAZINE-2-CARBOXYLIC ACID Chemical Properties,Uses,Production
Chemical Properties
White powder
Synthesis
2762-32-5
24424-99-5
181955-79-3
General procedure for the synthesis of 1,4-bis-BOC-2-piperazinecarboxylic acid from 2-piperazinecarboxylic acid and di-tert-butyl dicarbonate: In a 1 L round bottom flask, 15.76 g NaOH (394 mmol) was dissolved in 390 mL of water, followed by the addition of 20 g of 2-piperazinecarboxylic acid (98 mmol) in batches to obtain a colorless solution. A solution of 50 mL of Boc2O (215 mmol) dissolved in 1,4-dioxane was added slowly and dropwise while the temperature was maintained below +5 °C. Upon completion of the reaction, the mixture was cooled to +5 °C and the pH was subsequently adjusted to 3 with 3N HCl. The suspension was extracted with 300 mL of ethyl acetate (AcOEt), the organic phases were combined and dried over sodium sulfate. After vacuum evaporation, 22.7 g of white solid product was obtained. The aqueous phase was acidified with 3N HCl to pH=3 and then extracted with 2×100mL ethyl acetate (AcOEt), and the organic phases were similarly dried with sodium sulfate and then vacuum evaporated to give a second batch of 7.9g of product. The two batches of product were combined to give the final 1,4-bis-BOC-2-piperazinecarboxylic acid (30.6 g, 94% yield). The product was confirmed by 1H-NMR (400 MHz, DMSO-d6): δ 1.33 (18H, m), 2.70-4.50 (8H, m), 12.9 (1H, s); the mass spectrum (ES) showed m/z 330 [M+H]+.
References
[1] Patent: WO2008/148853, 2008, A1. Location in patent: Page/Page column 157-158
[2] Patent: US2014/288045, 2014, A1. Location in patent: Paragraph 0531
[3] Angewandte Chemie - International Edition, 2018,
[4] Angew. Chem., 2018, vol. 130, # 44, p. 14768 - 14773,6
[5] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 23, p. 4241 - 4244
1,4-BIS(N-BOC)PIPERAZINE-2-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | 52513593@qq.com | CHINA | 2972 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Changzhou Ditong Chemical Co.,Ltd | +86-0519-88298848 | info@edengenechem.com | China | 2165 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52704 | 58 |
| CR Corporation Limited | +8613062833949 | fred.wen@crcorporation.cn | China | 8645 | 58 |
View Lastest Price from 1,4-BIS(N-BOC)PIPERAZINE-2-CARBOXYLIC ACID manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2023-03-30 | 1,4-BIS(N-BOC)PIPERAZINE-2-CARBOXYLIC ACID
181955-79-3
|
1kg | 98.0% | 10000kg | LY Global chemicals co.,ltd . |
-
- 1,4-BIS(N-BOC)PIPERAZINE-2-CARBOXYLIC ACID
181955-79-3
- 98.0%
- LY Global chemicals co.,ltd .
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