6-Fluoro-1,2,3,4-tetrahydro-2-methylquinoline
- CAS No.
- 42835-89-2
- Chemical Name:
- 6-Fluoro-1,2,3,4-tetrahydro-2-methylquinoline
- Synonyms
- 6-Fluoro-1;4-tetrahydro-2-Methylquinoline;6-fluoro-tetrahydro-quinaldine;6-Fluoro-1,2,3,4-tetrahydro-2-methylquinoline;1,2,3,4-Tetrahydro-6-fluoro-2-Methylquinoline;2-Methyl-6-fluoro-1,2,3,4-tetrahydroquinoline;1,2,3,4-Tetrahydro-2-methyl-6-fluoroquinoline;Quinoline, 6-fluoro-1,2,3,4-tetrahydro-2-methyl-;6-FLUORO-2-METHYL-1,2,3,4-TETRAHYDROQUINOLINE 99;6-Fluoro-2-methyl-1,2,3,4-tetrahydroquinoline 99%
- CBNumber:
- CB0501118
- Molecular Formula:
- C10H12FN
- Molecular Weight:
- 165.21
- MDL Number:
- MFCD00040976
- MOL File:
- 42835-89-2.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 6-Fluoro-1,2,3,4-tetrahydro-2-methylquinoline | TRC-F593800-500MG | 500mg | $193 |
| 6-Fluoro-1,2,3,4-tetrahydro-2-methylquinoline | TRC-F593800-1G | 1g | $319 |
| 6-Fluoro-1,2,3,4-tetrahydro-2-methylquinoline | TRC-F593800-100MG | 100mg | $97 |
| 6-Fluoro-1,2,3,4-tetrahydro-2-methylquinoline | FF23361 | 0.25g | $214.17 |
| 6-Fluoro-1,2,3,4-tetrahydro-2-methylquinoline | FF23361 | 0.5g | $285.56 |
| Melting point | 31-33°C |
|---|---|
| Boiling point | 254.6±29.0 °C(Predicted) |
| Density | 1.0416 (estimate) |
| Flash point | >110°C |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 5.21±0.40(Predicted) |
| color | Off-White to Pale Yello |
| optical activity | 1.30°(C=0.01g/ml CHCL3) |
| CAS DataBase Reference | 42835-89-2 |
| FDA UNII | AZP5HK897S |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H319-H335-H315 |
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-37/39 |
| Hazard Note | Irritant |
| HS Code | 2933499090 |
6-Fluoro-1,2,3,4-tetrahydro-2-methylquinoline price More Price(52)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | TRC-F593800-500MG | 6-Fluoro-1,2,3,4-tetrahydro-2-methylquinoline | 42835-89-2 | 500mg | $193 | 2026-06-03 | Buy |
| TRC | TRC-F593800-1G | 6-Fluoro-1,2,3,4-tetrahydro-2-methylquinoline | 42835-89-2 | 1g | $319 | 2026-06-03 | Buy |
| TRC | TRC-F593800-100MG | 6-Fluoro-1,2,3,4-tetrahydro-2-methylquinoline | 42835-89-2 | 100mg | $97 | 2026-06-03 | Buy |
| Biosynth | FF23361 | 6-Fluoro-1,2,3,4-tetrahydro-2-methylquinoline | 42835-89-2 | 0.25g | $214.17 | 2026-06-04 | Buy |
| Biosynth | FF23361 | 6-Fluoro-1,2,3,4-tetrahydro-2-methylquinoline | 42835-89-2 | 0.5g | $285.56 | 2026-06-04 | Buy |
6-Fluoro-1,2,3,4-tetrahydro-2-methylquinoline Chemical Properties,Uses,Production
Chemical Properties
white to yellowish crystalline low melting solid
Uses
Intermediate in the production of anti-cancer quinoline derivatives and antibacterial agents
Synthesis
1128-61-6
42835-89-2
General procedure for the synthesis of 6-fluoro-1,2,3,4-tetrahydro-2-methylquinoline from 6-fluoro-2-methylquinoline: in a round-bottomed flask, pre-dried in an oven, a magnetic stirrer was added, followed by the sequential addition of 6-fluoro-2-methylquinoline (0.1 mmol), PCCP (1 mol%), Hantzsch dihydropyridine (3.0 equiv), and CHCl3 (2 mL). The reaction mixture was stirred continuously for 2 hours at room temperature. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The resulting residue was purified by silica gel column chromatography with the eluent of hexane/EtOAc (20:1, v/v) to afford the target product 6-fluoro-1,2,3,4-tetrahydro-2-methylquinoline.
References
[1] Synlett, 2008, # 6, p. 900 - 902
[2] Tetrahedron Letters, 2017, vol. 58, # 21, p. 2050 - 2053
[3] ACS Medicinal Chemistry Letters, 2017, vol. 8, # 11, p. 1183 - 1187
[4] Chemistry - A European Journal, 2015, vol. 21, # 14, p. 5370 - 5379
[5] Journal of the American Chemical Society, 2015, vol. 137, # 36, p. 11718 - 11724
6-Fluoro-1,2,3,4-tetrahydro-2-methylquinoline Preparation Products And Raw materials
Raw materials
Preparation Products
6-Fluoro-1,2,3,4-tetrahydro-2-methylquinoline Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | +86-13017695106 +86-13676922317 | jiuyitime@fdachem.com | China | 16512 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30224 | 58 |
| Finetech Industry Limited | +86-27-8746-5837 +8619945049750 | info@finetechnology-ind.com | China | 9539 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52704 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +86-571-86217390; +8618058761490 | info@gihichemicals.com | China | 49962 | 58 |
| Xuzhou B&C Chemical Technology Co., Ltd | +86-400-0516-021 +8617855106283 | info@bcpharma.com | China | 2732 | 58 |
| Aceschem Inc. | +1-817863-6948 +1-（817）863-6948 | sales@aceschem.com | United States | 19632 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501; +undefined18621343501 | product@acmec-e.com | China | 33324 | 58 |
View Lastest Price from 6-Fluoro-1,2,3,4-tetrahydro-2-methylquinoline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-17 | 6-Fluoro-2-methyl-1,2,3,4-tetrahydroquinoline
42835-89-2
|
$2.20-8.80 | 1kg | 99% | 100kg | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD |
-
- 6-Fluoro-2-methyl-1,2,3,4-tetrahydroquinoline
42835-89-2
- $2.20-8.80
- 99%
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
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