Source

Rabbit

Reactivity

Human

Background

Wilms' Tumor 1 is a transcription factor named from Wilms' Tumor 1, an embryonal malignancy of the kidneys that is caused by mutations in the WT1 gene. It is highly important in development, particularly of the genitourinary system, and mutations and dysregulation of expression of WT1 result in a variety of syndromes affecting the genitourinary system and other tissues.WT1 has a myriad of biological functions and a host of interacting partners and target genes. It can behave as a transcriptional activator, or a repressor, and can act as an oncogene or a tumor suppressor. It exerts influence over the epigenetic landscape, and also has post translational influence of gene expression through RNA interactions. The diverse biological roles of WT1 have been attributed to the existence of multiple isoforms and post translation modifications of the protein.

References

[1] Royer-Pokora, B. et al. (2004) Am J Med Genet A 127A, 249-57.
[2] Kohsaka, T. et al. (1999) Hum Mutat 14, 466-70.
[3] Little, M. et al. (2000) Hum Mutat 15, 389.
[4] Takata, A. et al. (2000) J Med Genet 37, 698-701.
[5] Suri, M. et al. (2007) Am J Med Genet A 143A, 2312-20.
[6] Toska, E. and Roberts, S.G. (2014) Biochem J 461, 15-32.
[7] Yang, L. et al. (2007) Leukemia 21, 868-76.
[8] Weiss, T.C. and Romaniuk, P.J. (2009) Biochemistry 48, 148-55.
[9] Haber, D.A. et al. (1991) Proc Natl Acad Sci U S A 88, 9618-22.

Raw materials

Preparation Products