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ChemicalBook >> CAS DataBase List >>(2-PIPERIDIN-4-YL-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER

(2-PIPERIDIN-4-YL-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER

CAS No.
165528-81-4
Chemical Name:
(2-PIPERIDIN-4-YL-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER
Synonyms
4-(N-BOC-2-AMINOETHYL)PIPERIDINE;4-(2-Boc-aminoethyL;4-(BOC-AMINOETHYL)PIPERIDINE;4-(2-BOC-AMINOETHYL) PIPERIDINE;4-(2-BOC-AMINOETHYL)-1-PIPERIDINE;4-(2-Aminothyl)piperidine,N2-BOC protected;TERT-BUTYL (2-PIPERIDIN-4-YLETHYL)CARBAMATE;4-(2-Aminoethyl)piperidine, 4-BOC protected;4-(2-Aminoethyl)piperidine, N2-BOC protected;tert-butyl N-[2-(piperidin-4-yl)ethyl]carbamate
CBNumber:
CB0685412
Molecular Formula:
C12H24N2O2
Molecular Weight:
228.33
MDL Number:
MFCD01318373
MOL File:
165528-81-4.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-27 22:51:05
Product description Number Pack Size Price
4-(2-Boc-aminoethyl)piperidine Asreported 266250 500mg $333
4-(2-Boc-aminoethyl)piperidine Asreported 266250 1g $529
4-(2-Boc-aminoethyl)piperidine Asreported 266250 2g $726
4-(2-Boc-aminoethyl)piperidine Asreported 266250 5g $1000
4-(2-Aminoethyl)piperidine, 4-BOC protected 95% OR2257 1g $54
More product size

(2-PIPERIDIN-4-YL-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER Properties

Boiling point 337.3±15.0 °C(Predicted)
Density 0.971±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
pka 12.86±0.46(Predicted)
form liquid
color Colourless to light yellow
InChI InChI=1S/C12H24N2O2/c1-12(2,3)16-11(15)14-9-6-10-4-7-13-8-5-10/h10,13H,4-9H2,1-3H3,(H,14,15)
InChIKey RQRMFFGCUUGYPC-UHFFFAOYSA-N
SMILES C(OC(C)(C)C)(=O)NCCC1CCNCC1
CAS DataBase Reference 165528-81-4(CAS DataBase Reference)
UNSPSC Code 12352200

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H317-H319
Precautionary statements  P280-P305+P351+P338
Hazard Codes  Xi
WGK Germany  WGK 3
HS Code  2933320000
Storage Class 11 - Combustible Solids

(2-PIPERIDIN-4-YL-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER price More Price(53)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological 266250 4-(2-Boc-aminoethyl)piperidine Asreported 165528-81-4 500mg $333 2026-06-03 Buy
Usbiological 266250 4-(2-Boc-aminoethyl)piperidine Asreported 165528-81-4 1g $529 2026-06-03 Buy
Usbiological 266250 4-(2-Boc-aminoethyl)piperidine Asreported 165528-81-4 2g $726 2026-06-03 Buy
Usbiological 266250 4-(2-Boc-aminoethyl)piperidine Asreported 165528-81-4 5g $1000 2026-06-03 Buy
Apolloscientific OR2257 4-(2-Aminoethyl)piperidine, 4-BOC protected 95% 165528-81-4 1g $54 2026-06-04 Buy
Product number Packaging Price Buy
266250 500mg $333 Buy
266250 1g $529 Buy
266250 2g $726 Buy
266250 5g $1000 Buy
OR2257 1g $54 Buy

(2-PIPERIDIN-4-YL-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER Chemical Properties,Uses,Production

Uses

4-(2-BOC-aminoethyl)piperidine is mainly used as a pharmaceutical intermediate, and some literature reports that it can be used to prepare SHP2 inhibitors.

Synthesis

Carbamic acid, N-[2-(4-pyridinyl)ethyl]-, 1,1-dimethylethylester

109573-05-9

(2-PIPERIDIN-4-YL-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER

165528-81-4

General procedure for the synthesis of 4-(2-Boc-aminoethyl)piperidine from tert-butyl N-[2-(pyridin-4-yl)ethyl]carbamate: tert-butyl N-[2-(pyridin-4-yl)ethyl]carbamate (26.9 g, 120.9 mmol) was dissolved in methanol (370 mL) and cooled to 0 °C. Aqueous 6N hydrochloric acid (20.2 mL, 120.9 mmol) was slowly added at 0 °C. Subsequently, platinum (IV) oxide (1.37 g, 6.05 mmol) was added to the reaction mixture at room temperature and the hydrogenation reaction was carried out under hydrogen (1000 psi) atmosphere for 24 hours. Upon completion of the reaction, the mixture was filtered through an Arbocel pad and the filter cake was washed sequentially with methanol (300 mL) and water (100 mL). The filtrate was concentrated under reduced pressure. The concentrated crude product was diluted with saturated aqueous sodium bicarbonate (150 mL) and extracted with dichloromethane (50 mL). The organic layer was washed with water (2 x 50 mL). The aqueous layers were combined, alkalized with 30% aqueous sodium hydroxide (30 mL) and then extracted with dichloromethane (8 x 200 mL). All organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give 4-(2-Boc-aminoethyl)piperidine as a clear viscous oil (26.8 g, 97% yield). The product was characterized by 1H NMR (400 MHz, CDCl3) and LCMS: 1H NMR δ 1.17 (m, 2H), 1.41 (m, 10H), 1.68 (m, 2H), 2.58 (m, 2H), 3.09 (m, 6H), 4.53 (s, 1H); LCMS Rt = 1.73 min, MS m/z 229 [M + H ]+.

References

[1] Patent: WO2015/181797, 2015, A1. Location in patent: Page/Page column 132
[2] Patent: WO2004/87145, 2004, A2. Location in patent: Page/Page column 31
[3] Bioorganic and Medicinal Chemistry Letters, 1999, vol. 9, # 9, p. 1317 - 1322
[4] Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 17, p. 2325 - 2330
[5] Journal of Medicinal Chemistry, 2006, vol. 49, # 14, p. 4116 - 4126

(2-PIPERIDIN-4-YL-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials

Global( 108)Suppliers
Supplier Tel Email Country ProdList Advantage
Chembon Pharmaceutical Co., Ltd. 		+86-28-8425-2981 CHINA 722 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
Accela ChemBio Inc. 		+1-858-6993322 +86-18019713315 info@accelachem.com United States 21193 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED 		sales@conier.com China 49979 58
career henan chemical co 		+86-0371-86658258 factory@coreychem.com China 29807 58
Fuxin Pharmaceutical 		+86-021-021-50872116 contact@fuxinpharm.com China 9976 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		+8613580539051 joe@yuhengpharm.com CHINA 21142 58
Hefei Hirisun Pharmatech Co., Ltd 		+8615056975894 shawn@hirisunpharm.com CHINA 9911 58
Dayang Chem (Hangzhou) Co.,Ltd. 		+86-0571-88938639 17705817739 info@dycnchem.com China 52704 58

View Lastest Price from (2-PIPERIDIN-4-YL-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(2-PIPERIDIN-4-YL-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER pictures 2021-08-12 (2-PIPERIDIN-4-YL-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER
165528-81-4
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd
(2-PIPERIDIN-4-YL-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER pictures 2019-12-23 (2-PIPERIDIN-4-YL-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER
165528-81-4
 $1.00 1g 99% 1000KGS Career Henan Chemical Co

(2-PIPERIDIN-4-YL-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER Spectrum

TERT-BUTYL (2-PIPERIDIN-4-YLETHYL)CARBAMATE 4-(2-Aminoethyl)piperidine, N2-BOC protected 4-(2-BOC-AMINOETHYL)-1-PIPERIDINE 4-(2-BOC-AMINOETHYL) PIPERIDINE 4-(BOC-AMINOETHYL)PIPERIDINE (2-PIPERIDIN-4-YL-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER 4-(2-Aminoethyl)piperidine, 4-BOC protected tert-Butyl [2-(piperidin-4-yl)ethyl]carbamate, N-(tert-Butoxycarbonyl)-2-(piperidin-4-yl)ethylamine 4-(2-Aminothyl)piperidine,N2-BOC protected Carbamic acid, N-[2-(4-piperidinyl)ethyl]-, 1,1-dimethylethyl ester tert-butyl N-[2-(piperidin-4-yl)ethyl]carbamate 4-(2-Boc-aminoethyL 4-(N-BOC-2-AMINOETHYL)PIPERIDINE 165528-81-4 Benzothiophenes ,Benzopyrans ,Thiophenes pharmacetical
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