METHYL 6-METHOXY-1H-INDOLE-2-CARBOXYLATE
- CAS No.
- 98081-83-5
- Chemical Name:
- METHYL 6-METHOXY-1H-INDOLE-2-CARBOXYLATE
- Synonyms
- AKOS JY2083317;6-Methoxy-2-indolecarboxylate;2-Methoxycarbonyl-6-methoxyindole;METHYL 6-METHOXY-2-INDOLECARBOXYLATE;Methyle6-methoxy-2-indolecarboxylate;METHYL 6-METHOXY-INDOLE-2-CARBOXYLATE;METHYL 6-METHOXY-1H-INDOLE-2-CARBOXYLATE;METHYL 6-METHOXY-2-INDOLECARBOXYLATE, 99 %;6-methoxy-3-methyl-1H-indole-2-carboxylate;6-methoxyindole-2-carboxylate methyl ester
- CBNumber:
- CB0714549
- Molecular Formula:
- C11H11NO3
- Molecular Weight:
- 205.21
- MDL Number:
- MFCD00134301
- MOL File:
- 98081-83-5.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Methyl 6-methoxy-2-indolecarboxylate 99% | 365572 | 1g | $56.9 |
| METHYL 6-METHOXY-INDOLE-2-CARBOXYLATE 97% | 64235 | 1G | $33 |
| METHYL 6-METHOXY-INDOLE-2-CARBOXYLATE 97% | 64235 | 5G | $132 |
| METHYL 6-METHOXY-INDOLE-2-CARBOXYLATE 97% | 64235 | 10G | $251 |
| 6-Methoxyindole-2-carboxylic acid methyl ester | FM08190 | 10g | $227 |
| More product size | |||
| Melting point | 117-119 °C(lit.) |
|---|---|
| Boiling point | 370.1±22.0 °C(Predicted) |
| Density | 1.253±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| form | Powder |
| pka | 15.20±0.30(Predicted) |
| color | White to beige |
| InChI | InChI=1S/C11H11NO3/c1-14-8-4-3-7-5-10(11(13)15-2)12-9(7)6-8/h3-6,12H,1-2H3 |
| InChIKey | OPUUCOLVBDQWEY-UHFFFAOYSA-N |
| SMILES | N1C2=C(C=CC(OC)=C2)C=C1C(OC)=O |
| CAS DataBase Reference | 98081-83-5(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29339980 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
METHYL 6-METHOXY-1H-INDOLE-2-CARBOXYLATE price More Price(74)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 365572 | Methyl 6-methoxy-2-indolecarboxylate 99% | 98081-83-5 | 1g | $56.9 | 2023-06-20 | Buy |
| AstaTech | 64235 | METHYL 6-METHOXY-INDOLE-2-CARBOXYLATE 97% | 98081-83-5 | 1G | $33 | 2026-04-30 | Buy |
| AstaTech | 64235 | METHYL 6-METHOXY-INDOLE-2-CARBOXYLATE 97% | 98081-83-5 | 5G | $132 | 2026-04-30 | Buy |
| AstaTech | 64235 | METHYL 6-METHOXY-INDOLE-2-CARBOXYLATE 97% | 98081-83-5 | 10G | $251 | 2026-04-30 | Buy |
| Biosynth | FM08190 | 6-Methoxyindole-2-carboxylic acid methyl ester | 98081-83-5 | 10g | $227 | 2026-06-04 | Buy |
METHYL 6-METHOXY-1H-INDOLE-2-CARBOXYLATE Chemical Properties,Uses,Production
Chemical Properties
Pale pink crystals
Uses
Methyl 6-methoxy-2-indolecarboxylate is suitable for use in the production of dyes by Escherichia coli expressing naphthalene dioxygenase (NDO) and toluene dioxygenase (TDO). It is also suitable for use in the production of dyes by Escherichia coli expressing multicomponent phenol hydroxylase (mPH) from Pseudomonas sp. strains KL33 and KL28.
Synthesis
98081-75-5
98081-83-5
General procedure for the synthesis of methyl 6-methoxy-1H-indole-2-carboxylate from compound (CAS: 98081-75-5): compound 10 (3 g, 13.9 mmol) was dissolved in xylene (42 mL) under refluxing conditions and slowly added dropwise to a preheated to refluxing solution of xylene (55 mL), the dropwise process lasted for 20 minutes. After the dropwise addition was completed, the reaction mixture was continued to be stirred at reflux for 6 hours. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently concentrated under reduced pressure to remove the solvent. By recrystallization from benzene, compound 11a (1.97 g, 75% yield) was obtained as a white solid. Thin layer chromatography (TLC) analysis showed an Rf value of 0.40 (unfolding agent was hexane/ethyl acetate = 2:1).1H NMR (400 MHz, CDCl3) δ 8.82 (broad single peak, 1H), 7.56 (double peaks, 1H, J = 9.2 Hz), 7.36 (single peak, 1H), 7.16 (single peak, 1H), 6.83 (multiple peaks, 2H), and 3.93 (single peak, 3H), 3.86 (single peak, 3H).13C NMR (100 MHz, CDCl3) δ 162.4, 158.9, 138.0, 126.0, 123.4, 121.8, 112.3, 109.2, 93.6, 55.4, 51.8.
References
[1] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 6, p. 1740 - 1742
[2] Journal of Organic Chemistry, 2009, vol. 74, # 17, p. 6442 - 6451
[3] Inorganic Chemistry, 2017, vol. 56, # 8, p. 4253 - 4257
[4] Chemical Communications, 2010, vol. 46, # 37, p. 6926 - 6928
[5] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 10, p. 3057 - 3061
METHYL 6-METHOXY-1H-INDOLE-2-CARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10403 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30224 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52704 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25356 | 58 |
| Coresyn Pharmatech Co., Ltd. | +86-571-86626709 +86-18157142896 | cbc@coresyn.com | China | 9984 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
| Henan Allgreen Chemical Co.,LTD | +86-37155567971 +86-13633837469 | info@allgreenchem.com | China | 5998 | 58 |
View Lastest Price from METHYL 6-METHOXY-1H-INDOLE-2-CARBOXYLATE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2021-08-12 | METHYL 6-METHOXY-1H-INDOLE-2-CARBOXYLATE
98081-83-5
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2019-12-26 | METHYL 6-METHOXY-1H-INDOLE-2-CARBOXYLATE
98081-83-5
|
$6.60 | 1KG | 97%-99% | 1kg-1000kg | Career Henan Chemical Co |
-
- METHYL 6-METHOXY-1H-INDOLE-2-CARBOXYLATE
98081-83-5
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- METHYL 6-METHOXY-1H-INDOLE-2-CARBOXYLATE
98081-83-5
- $6.60
- 97%-99%
- Career Henan Chemical Co
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