Risedronic acid
- CAS No.
- 105462-24-6
- Chemical Name:
- Risedronic acid
- Synonyms
- RISEDRONATE;RISEDRONIC ACID;RESEDRONIC ACID;Risedronic Acid RS;Risedronate sodium≥97%;3-(Acetic acid)Pyridine;Risedronic acid (Actonel);RISEDRONIC ACID MONOHYDRATE;Risedronate (Risedronic Acid);Risedronic acid (Risedronate)
- CBNumber:
- CB1118762
- Molecular Formula:
- C7H11NO7P2
- Molecular Weight:
- 283.11
- MDL Number:
- MFCD00867080
- MOL File:
- 105462-24-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Risedronic acid monohydrate | FH61572 | 10g | $220 |
| Risedronic acid monohydrate | FH61572 | 25g | $343.75 |
| Risedronic acid monohydrate | FH61572 | 50g | $550 |
| Risedronic acid monohydrate | FH61572 | 100g | $894 |
| Risedronic acid monohydrate | FH61572 | 250g | $1375 |
| More product size | |||
| Melting point | >232°C (subl.) |
|---|---|
| Boiling point | 692.3±65.0 °C(Predicted) |
| Density | 1.870±0.06 g/cm3(Predicted) |
| storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| solubility | Aqueous Base (Slightly), Methanol (Very Slightly, Heated, Sonicated) |
| form | Solid |
| pka | 1.41±0.10(Predicted) |
| color | White to Off-White |
| Stability | Hygroscopic |
| InChI | InChI=1S/C7H11NO7P2/c9-7(16(10,11)12,17(13,14)15)4-6-2-1-3-8-5-6/h1-3,5,9H,4H2,(H2,10,11,12)(H2,13,14,15) |
| InChIKey | IIDJRNMFWXDHID-UHFFFAOYSA-N |
| SMILES | C(P(=O)(O)O)(P(=O)(O)O)(O)CC1=CC=CN=C1 |
| CAS DataBase Reference | 105462-24-6(CAS DataBase Reference) |
| FDA UNII | KM2Z91756Z |
| NCI Dictionary of Cancer Terms | risedronate |
| ATC code | M05BA07 |
| EPA Substance Registry System | Phosphonic acid, P,P'-[1-hydroxy-2-(3-pyridinyl)ethylidene]bis- (105462-24-6) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P280-P305+P351+P338-P310 |
| Hazardous Substances Data | 105462-24-6(Hazardous Substances Data) |
| REACH Registrations | Active |
Risedronic acid price More Price(52)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | FH61572 | Risedronic acid monohydrate | 105462-24-6 | 10g | $220 | 2026-06-04 | Buy |
| Biosynth | FH61572 | Risedronic acid monohydrate | 105462-24-6 | 25g | $343.75 | 2026-06-04 | Buy |
| Biosynth | FH61572 | Risedronic acid monohydrate | 105462-24-6 | 50g | $550 | 2026-06-04 | Buy |
| Biosynth | FH61572 | Risedronic acid monohydrate | 105462-24-6 | 100g | $894 | 2026-06-04 | Buy |
| Biosynth | FH61572 | Risedronic acid monohydrate | 105462-24-6 | 250g | $1375 | 2026-06-04 | Buy |
Risedronic acid Chemical Properties,Uses,Production
Uses
Risedronic Acid is a pyridinyl biphosphonate bone resorption inhibitor. It is a potentially useful biophosphonate for bone resorption analysis.
Definition
ChEBI: Risedronic acid is a member of pyridines. It is a third generation bisphosphonate that is used for the treatment of some forms of osteoperosis and Paget's disease. It functions by preventing resorption of bone.
in vivo
Risedronic acid (Risedronate) (30 μg/kg; subcutaneous injection; once every other day; 3 weeks) prevents radiation-induced osteoporosis in female C57BL/6 mice irradiated with 2 Gy X-rays, inhibits trabecular bone loss and microstructural damage, and suppresses the increase in osteoclast number and serum TRAP5b2.
Risedronic acid (10-25 mg/kg; intraperitoneal injection; once a day; 7 days) inhibits parasitemia in BALB/c mice infected withPlasmodium bergheistrain ANKA, but does not prolong the survival time of mice3.
| Animal Model: | Female C57BL/6 mice (20-week-old, ~23 g) irradiated with 2 Gy X-rays whole-body2 |
| Dosage: | 30 μg/kg |
| Administration: | Subcutaneous injection, once every other day, for 3 weeks |
| Result: | Prevented the radiation-induced increase in osteoclast number, surface, and TRAP5b. |
| Animal Model: | Male BALB/c mice (3-4 weeks old) infected withPlasmodium bergheistrain ANKA by intraperitoneal injection of1×106blood-stage parasites3 |
| Dosage: | 10 mg/kg, 15 mg/kg, 20 mg/kg, 25 mg/kg |
| Administration: | Intraperitoneal injection, once a day, for 7 days |
| Result: | Led to an 88.9% inhibition of the rodent parasite Plasmodium berghei in mice on the seventh day of treatment. |
Mode of action
Risedronatic acid binds to bone hydroxyapatite. Bone resorption causes local acidification, releasing risedronic acid which is that taken into osteoclasts by fluid-phase endocytosis. Endocytic vesicles are acidified, releasing risedronic acid to the cytosol of osteoclasts where they induce apoptosis through inhbition of farnesyl pyrophosphate synthase. Inhibition of osteoclasts results in decreased bone resorption.
Risedronic acid Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Hi-Tech Chemistry Corp | 0519-86626038 | yuhh@hitechem.com | CHINA | 810 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21587 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Zhejiang ZETian Fine Chemicals Co. LTD | +8618957127338 | stella@zetchem.com | China | 2994 | 58 |
| Shandong chuangyingchemical Co., Ltd. | 18853181302 | sale@chuangyingchem.com | CHINA | 5906 | 58 |
| Shenzhen Excellent Biotech Co., Ltd. | 13480692018 | ramyan@ex-biotech.com | CHINA | 954 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81139210 +86-18192627656 | 1059@dideu.com | China | 3587 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8618531123677 | faithe@yan-xi.com | China | 5853 | 58 |
View Lastest Price from Risedronic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-08 | Risedronic acid
105462-24-6
|
1KG | 98.0% | 100kg | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-05-26 | Risedronic Acid
105462-24-6
|
$48.00-179.00 | 99.87% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-05-26 | Risedronic Acid
105462-24-6
|
$48.00-179.00 | 99.87% | 10g | TargetMol Chemicals Inc. |
-
- Risedronic acid
105462-24-6
- $0.00
- 98.0%
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Risedronic Acid
105462-24-6
- $48.00-179.00
- 99.87%
- TargetMol Chemicals Inc.
-
- Risedronic Acid
105462-24-6
- $48.00-179.00
- 99.87%
- TargetMol Chemicals Inc.
