3-HYDROXY-4-BENZYLOXY BENZALDEHYDE
- CAS No.
- 4049-39-2
- Chemical Name:
- 3-HYDROXY-4-BENZYLOXY BENZALDEHYDE
- Synonyms
- 4-BENZLOXY-3-HYDROXYBENZALDEHYDE;4-BENZLOXY-3-HYDROXYBENZALDEHYLE;4-BENZYLOXY-3-HYDROXYBENZALDEHYDE;4-HYDROXY-4-BENZYLOXYBENZALDEHYDE;3-HYDROXY-4-BENZYLOXY BENZALDEHYDE;Protocatechuic Aldehyde-4-benzyl Ether;3-Hydroxy-4-(phenylmethoxy)benzaldehyde;Benzaldehyde, 3-hydroxy-4-(phenylmethoxy)-;4-hydroxy-4-phenylmethoxy-1-cyclohexa-1,5-dienecarboxaldehyde
- CBNumber:
- CB1140624
- Molecular Formula:
- C14H12O3
- Molecular Weight:
- 228.24
- MDL Number:
- MFCD03840812
- MOL File:
- 4049-39-2.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 3-Hydroxy-4-(benzyloxy)benzaldehyde 97% | AS85682 | 1g | $100 |
| 3-Hydroxy-4-(benzyloxy)benzaldehyde 97% | AS85682 | 5g | $420 |
| 4-(Benzyloxy)-3-hydroxybenzaldehyde | 291796 | 1.00g | $64 |
| 4-(Benzyloxy)-3-hydroxybenzaldehyde | 291796 | 5.00g | $270 |
| 4-(Benzyloxy)-3-hydroxybenzaldehyde | 291796 | 10.00g | $490 |
| Melting point | 120 °C(Solv: ethanol (64-17-5)) |
|---|---|
| Boiling point | 403.3±30.0 °C(Predicted) |
| Density | 1.238±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 8.79±0.35(Predicted) |
| color | Off-White to Light Brown |
| InChI | InChI=1S/C14H12O3/c15-9-12-6-7-14(13(16)8-12)17-10-11-4-2-1-3-5-11/h1-9,16H,10H2 |
| InChIKey | HUNGEAFDVLSPAM-UHFFFAOYSA-N |
| SMILES | C(=O)C1=CC=C(OCC2=CC=CC=C2)C(O)=C1 |
| CAS DataBase Reference | 4049-39-2 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P261-P280-P305+P351+P338-P304+P340 |
3-HYDROXY-4-BENZYLOXY BENZALDEHYDE price More Price(61)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Activate Scientific | AS85682 | 3-Hydroxy-4-(benzyloxy)benzaldehyde 97% | 4049-39-2 | 1g | $100 | 2026-06-04 | Buy |
| Activate Scientific | AS85682 | 3-Hydroxy-4-(benzyloxy)benzaldehyde 97% | 4049-39-2 | 5g | $420 | 2026-06-04 | Buy |
| Matrix Scientific | 291796 | 4-(Benzyloxy)-3-hydroxybenzaldehyde | 4049-39-2 | 1.00g | $64 | 2026-05-19 | Buy |
| Matrix Scientific | 291796 | 4-(Benzyloxy)-3-hydroxybenzaldehyde | 4049-39-2 | 5.00g | $270 | 2026-05-19 | Buy |
| Matrix Scientific | 291796 | 4-(Benzyloxy)-3-hydroxybenzaldehyde | 4049-39-2 | 10.00g | $490 | 2026-05-19 | Buy |
3-HYDROXY-4-BENZYLOXY BENZALDEHYDE Chemical Properties,Uses,Production
Chemical Properties
Pale Yellow Solid
Uses
4-Benzyloxy-3-hydroxybenzaldehyde is useful for preparing quinazoline derivatives.
Synthesis
100-39-0
139-85-5
4049-39-2
To a solution of 3,4-dihydroxybenzaldehyde (2.03 g, 14.7 mmol) in acetone (150 mL) was added potassium carbonate (K2CO3, 3.05 g, 22.1 mmol) and benzyl bromide (1.74 mL, 14.7 mmol). The reaction mixture was stirred under reflux conditions for 4 hours. Upon completion of the reaction, the reaction mixture was filtered through Celite 535RVS and the filtrate was subsequently concentrated under reduced pressure. The residue was purified by column chromatography using toluene/ethyl acetate (13:1, v/v) as eluent to afford 4-(benzyloxy)-3-hydroxybenzaldehyde (2.12 g, 63% yield) as colorless prismatic crystals. The product characterization data were as follows: 1H NMR (300 MHz, CDCl3) δ 5.21 (2H, s), 5.77 (1H, s), 7.05 (1H, d, J = 8.2 Hz), 7.37-7.43 (7H, m), 9.86 (1H, s); 13C NMR (75 MHz, CDCl3) δ 71.2, 111.5, 114.4, 124.4, 127.9, 128.8, 128.9, 130.8, 135.2, 146.3, 150.9, 191.0; IR (ATR) νmax 3201, 1671, 1604, 1577, 1511, 1454, 1389, 1343, 1283, 1165, 1151, 1015 , 962, 874, 811, 786, 738, 698, 678 cm-1; EIMS m/z (relative intensity) 228 [M]+ (40), 91 (100); HR-EIMS m/z: [M]+ calculated C14H12O3 228.0786, measured 228.0789; melting point 120.0-122.0°C.
References
[1] Patent: WO2014/149793, 2014, A1. Location in patent: Page/Page column 59-60; 93; 96
[2] Bioorganic and Medicinal Chemistry, 2003, vol. 11, # 22, p. 4693 - 4711
[3] Chemistry - A European Journal, 1998, vol. 4, # 1, p. 33 - 43
[4] Journal of Natural Products, 2018, vol. 81, # 2, p. 371 - 377
[5] Organic Letters, 2012, vol. 14, # 15, p. 3902 - 3905
3-HYDROXY-4-BENZYLOXY BENZALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
3-HYDROXY-4-BENZYLOXY BENZALDEHYDE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81139210 +86-18192627656 | 1059@dideu.com | China | 3607 | 58 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 14015 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30224 | 58 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19987 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43333 | 58 |
| Sichuan Biosynce Pharmatech Co., Ltd. | +8619950309693 | diane@biosynce.com | China | 4871 | 58 |
| Shaanxi Dideu New Materials Co. Ltd | +86-18192503167 18192503167 | 1036@dideu.com | China | 7999 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Hebei Maipu Technology Co., LTD | 0311-13231111190 17734576190 | 1148032505@qq.com | China | 235 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532; 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
View Lastest Price from 3-HYDROXY-4-BENZYLOXY BENZALDEHYDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-12-12 | 3-HYDROXY-4-BENZYLOXY BENZALDEHYDE
4049-39-2
|
$2.00-3.00 | 1KG | 99% | 200000KG | Shaanxi Dideu Medichem Co. Ltd | |
 |
2025-12-01 | 3-HYDROXY-4-BENZYLOXY BENZALDEHYDE
4049-39-2
|
1kg | 99% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd |
-
- 3-HYDROXY-4-BENZYLOXY BENZALDEHYDE
4049-39-2
- $2.00-3.00
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- 3-HYDROXY-4-BENZYLOXY BENZALDEHYDE
4049-39-2
- $0.00
- 99%
- Shaanxi Dideu New Materials Co. Ltd
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