4-CHLOROTHIOPHENE-2-CARBOXYLIC ACID
- CAS No.
- 59614-95-8
- Chemical Name:
- 4-CHLOROTHIOPHENE-2-CARBOXYLIC ACID
- Synonyms
- 2-Carboxy-4-chlorothiophene;4-chlorothiene-2-carboxylic acid;4-chloro-2-thionylcarboxylic acid;4-Chloro-2-thiophenecarboxylic acid;4-CHLOROTHIOPHENE-2-CARBOXYLIC ACID;2-Thiophenecarboxylic acid, 4-chloro-
- CBNumber:
- CB1165438
- Molecular Formula:
- C5H3ClO2S
- Molecular Weight:
- 162.59
- MDL Number:
- MFCD00082876
- MOL File:
- 59614-95-8.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 4-Chlorothiophene-2-carboxylic Acid | TRC-C428893-500MG | 500mg | $268 |
| 4-Chlorothiophene-2-carboxylic Acid | TRC-C428893-250MG | 250mg | $147 |
| 4-Chlorothiophene-2-carboxylic Acid | TRC-C428893-10MG | 10mg | $59 |
| 4-Chlorothiophene-2- carboxylic acid | JCA61495 | 2.5g | $442.5 |
| 4-Chlorothiophene-2-carboxylic acid 95% | OR40031 | 100mg | $33 |
| More product size | |||
| Melting point | 131-132 °C(Solv: methanol (67-56-1)) |
|---|---|
| Boiling point | 298.0±20.0 °C(Predicted) |
| Density | 1.572±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 3.50±0.10(Predicted) |
| color | White to Off-White |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS07,GHS08,GHS09 |
|---|---|
| Signal word | Danger |
| Hazard statements | H312-H410-H372 |
| Precautionary statements | P273-P280-P302+P352+P312-P362+P364-P391-P501 |
| HS Code | 2934999090 |
4-CHLOROTHIOPHENE-2-CARBOXYLIC ACID price More Price(68)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | TRC-C428893-500MG | 4-Chlorothiophene-2-carboxylic Acid | 59614-95-8 | 500mg | $268 | 2026-06-03 | Buy |
| TRC | TRC-C428893-250MG | 4-Chlorothiophene-2-carboxylic Acid | 59614-95-8 | 250mg | $147 | 2026-06-03 | Buy |
| TRC | TRC-C428893-10MG | 4-Chlorothiophene-2-carboxylic Acid | 59614-95-8 | 10mg | $59 | 2026-06-03 | Buy |
| Biosynth | JCA61495 | 4-Chlorothiophene-2- carboxylic acid | 59614-95-8 | 2.5g | $442.5 | 2026-06-04 | Buy |
| Apolloscientific | OR40031 | 4-Chlorothiophene-2-carboxylic acid 95% | 59614-95-8 | 100mg | $33 | 2026-06-04 | Buy |
4-CHLOROTHIOPHENE-2-CARBOXYLIC ACID Chemical Properties,Uses,Production
Uses
4-Chlorothiophene-2-carboxylic Acid is a useful research chemical compound used as a chlroinating reagent in the preparation of 5-(2-furoyl)-, 5-(2-thenoyl)-, 5-(3-furoyl)- and 5-(3-thenoyl)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives.
Synthesis Reference(s)
Journal of Heterocyclic Chemistry, 13, p. 393, 1976 DOI: 10.1002/jhet.5570130241
Synthesis
35475-03-7
59614-95-8
General procedure for the synthesis of 4-chlorothiophene-2-carboxylic acid from methyl 5-chlorothiophene-2-carboxylate: to a solution of methyl 5-chlorothiophene-2-carboxylate (10.0 g, 61.5 mmol) in anhydrous methanol (55 mL) was slowly added concentrated sulfuric acid (5-7 mL). The reaction mixture was heated to 50 °C and maintained for 18 h for the reaction, followed by concentration under reduced pressure to remove the solvent. The concentrated residue was dissolved in dichloromethane and washed several times with saturated sodium bicarbonate solution to neutralize the acid. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford 10.85 g of the crude product of 4-chlorothiophene-2-carboxylic acid (~100% yield), which could be used in subsequent reactions without further purification.1H NMR (400 MHz, DMSO-d6): δ 7.66 (d, 1H, J = 4.0 Hz), 7.23 (d, 1H, J = 4.4 Hz), 7.23 (d, 1H, J = 4.4 Hz) 3.81 (s, 3H).
References
[1] Patent: US2018/201610, 2018, A1. Location in patent: Paragraph 0400; 0401
4-CHLOROTHIOPHENE-2-CARBOXYLIC ACID Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 | sales@frappschem.com | China | 880 | 50 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Hebei Jimi Trading Co., Ltd. | +86 319 5273535 | bestoneforyou@sina.com | CHINA | 287 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49979 | 58 | |
| career henan chemical co | +86-0371-86658258 | factory@coreychem.com | China | 29792 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-0519-85551759 | marketing1@neostarunited.com | China | 8828 | 58 |
| Chengdu Aslee Biopharmaceuticals, Inc. | 28-85305008 | CHINA | 964 | 58 | |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +86-189 4982 3763 | sales@tnjchem.com | China | 34563 | 58 |
View Lastest Price from 4-CHLOROTHIOPHENE-2-CARBOXYLIC ACID manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-09 | 4-CHLOROTHIOPHENE-2-CARBOXYLIC ACID
59614-95-8
|
$9.80 | 1g | ≥99% | 100kg | Career Henan Chemical Co | |
 |
2019-05-22 | 4-Chlorothiophene-2-carboxylic acid
59614-95-8
|
$1.00 | 1Kg | 99.95 | 500KG | Hebei Jimi Trading Co., Ltd. |
-
- 4-CHLOROTHIOPHENE-2-CARBOXYLIC ACID
59614-95-8
- $9.80
- ≥99%
- Career Henan Chemical Co
-
- 4-Chlorothiophene-2-carboxylic acid
59614-95-8
- $1.00
- 99.95
- Hebei Jimi Trading Co., Ltd.
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