Boc-D-Phenylglycine
- CAS No.
- 33125-05-2
- Chemical Name:
- Boc-D-Phenylglycine
- Synonyms
- BOC-PHG-OH;BOC-D-PHG-OH;(R)-2-((tert-butoxycarbonyl)aMino)-2-phenylacetic acid;(R)-N-tert-butoxycarbonyl-2-phenylglycine;N-(tert-Butoxycarbonyl)-D-2-phenylglycine;FS000066;BOC-L-PHG;ST5210539;BOC-L-PHG-OH;Boc-D-PhenyL
- CBNumber:
- CB1176908
- Molecular Formula:
- C13H17NO4
- Molecular Weight:
- 251.28
- MDL Number:
- MFCD00062043
- MOL File:
- 33125-05-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Boc-D-Phg-OH Novabiochem? | 8.53101-M | 5G | $268 |
| Boc-D-Phg-OH Novabiochem? | 8.53101-M | 25g | $1080 |
| Boc-D-Phg-OH ≥99.0% (TLC) | 15487 | 1g | $65 |
| Boc-D-Phg-OH ≥99.0% (TLC) | 15487 | 5g | $135 |
| N-(tert-Butoxycarbonyl)-D-2-phenylglycine >98.0%(T) | B3230 | 1g | $17 |
| More product size | |||
| Melting point | 88-91 °C |
|---|---|
| alpha | -142 º (c=1% in ethanol) |
| Boiling point | 407.2±38.0 °C(Predicted) |
| Density | 1.182±0.06 g/cm3(Predicted) |
| refractive index | -140 ° (C=1, EtOH) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | DMSO, Methanol |
| form | Crystalline Powder |
| pka | 3.51±0.10(Predicted) |
| color | White |
| optical activity | [α]20/D 141.0±5.0°, c = 1% in ethanol |
| Water Solubility | Insoluble in water. Slightly soluble in DMSO and methanol. |
| BRN | 3033982 |
| Major Application | peptide synthesis |
| InChI | InChI=1S/C13H17NO4/c1-13(2,3)18-12(17)14(9-11(15)16)10-7-5-4-6-8-10/h4-8H,9H2,1-3H3,(H,15,16) |
| InChIKey | KIAPYAZGXJCKQL-UHFFFAOYSA-N |
| SMILES | C(O)(=O)CN(C(OC(C)(C)C)=O)C1=CC=CC=C1 |
| CAS DataBase Reference | 33125-05-2(CAS DataBase Reference) |
| FDA UNII | 4PFG3246TW |
| UNSPSC Code | 12352209 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362+P364-P403+P233-P501c | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| Safety Statements | 24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29242990 | |||||||||
| Storage Class | 13 - Non Combustible Solids | |||||||||
| NFPA 704 |
|
Boc-D-Phenylglycine price More Price(104)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 8.53101-M | Boc-D-Phg-OH Novabiochem? | 33125-05-2 | 5G | $268 | 2026-04-30 | Buy |
| Sigma-Aldrich | 8.53101-M | Boc-D-Phg-OH Novabiochem? | 33125-05-2 | 25g | $1080 | 2026-04-30 | Buy |
| Sigma-Aldrich | 15487 | Boc-D-Phg-OH ≥99.0% (TLC) | 33125-05-2 | 1g | $65 | 2023-06-20 | Buy |
| Sigma-Aldrich | 15487 | Boc-D-Phg-OH ≥99.0% (TLC) | 33125-05-2 | 5g | $135 | 2023-06-20 | Buy |
| TCI Chemical | B3230 | N-(tert-Butoxycarbonyl)-D-2-phenylglycine >98.0%(T) | 33125-05-2 | 1g | $17 | 2026-04-30 | Buy |
Boc-D-Phenylglycine Chemical Properties,Uses,Production
Chemical Properties
White powder
Uses
It is a reagent of choice for assignment of absolute configuration of chiral primary amines by 1H NMR, giving better results than Mosher's acid ((R)-(+)--Methoxy--(trifluoromethyl)-phenyl-acetic acid. αR)-α-[[(1,1-Dimethylethoxy)carbonyl]amino]-benzeneacetic Acid is D-(+)-2-Phenylglycine with Boc protecting group. (αR)-α-[[(1,1-Dimethylethoxy)carbonyl]amino]-benzeneacetic Acid is used as part of a catalyst combination to catalyze regioselective [4 + 2] cycloadditions of β-substituted cyclic enones and polyconjugated malononitriles. It can also be used to catalyze stereoselective preparation of polyfunctional nitrocyclohexene carboxaldehydes.
reaction suitability
reaction type: Boc solid-phase peptide synthesis
Synthesis
24424-99-5
875-74-1
33125-05-2
(1) A mixture of (R)-2-amino-2-phenylacetic acid (200 g, 1.32 mol) and potassium carbonate (218 g, 1.58 mol) was dissolved in a solvent mixture of water (2.0 L) and methanol (0.5 L), and cooled to a temperature of less than 10°C. Di-tert-butyl dicarbonate (288 g, 1.32 mol) was added dropwise, and the reaction was stirred at room temperature after the addition. After the addition, the reaction was stirred at room temperature overnight. After completion of the reaction, the pH of the reaction solution was adjusted to 4-5 with 1 N hydrochloric acid, followed by extraction with ethyl acetate (1.0 L × 3). The organic phases were combined, washed with saturated saline (1.0 L × 1), dried over anhydrous sodium sulfate and concentrated under reduced pressure to give a white solid product (315 g) in 95% yield.
References
[1] Journal of Medicinal Chemistry, 2013, vol. 56, # 20, p. 8049 - 8065
[2] Journal of Medicinal Chemistry, 1991, vol. 34, # 3, p. 968 - 978
[3] Tetrahedron Letters, 1995, vol. 36, # 29, p. 5227 - 5230
[4] Patent: CN104592163, 2016, B. Location in patent: Paragraph 0041; 0042
[5] Patent: CN106748892, 2017, A. Location in patent: Paragraph 0051; 0053; 0054; 0055
Boc-D-Phenylglycine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sichuan HongRi Pharma-Tech Co.,Ltd | +8618382028708 | ni@enlaibio.com | China | 1103 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Taizhou Tianhong Biochemistry Technology Co., Ltd. | 0523-86132544 | sales@thbiochem.com | CHINA | 305 | 60 |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1803 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Jinan Shengqi pharmaceutical Co,Ltd | 86+18663751872 | christine@shengqipharm.com | CHINA | 491 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Shanghai Yingrui Biopharma Co.,Ltd | 21-33585366 | export01@shyrchem.com | CHINA | 1319 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
View Lastest Price from Boc-D-Phenylglycine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-17 | Boc-D-Phenylglycine
33125-05-2
|
1KG | 98%min | 500kgs | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-06-12 | Boc-D-Phg-OH
33125-05-2
|
1kg | 98% | 1T+ | Sichuan HongRi Pharma-Tech Co.,Ltd | ||
 |
2025-04-04 | Boc-D-Phenylglycine
33125-05-2
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd.
|
-
- Boc-D-Phenylglycine
33125-05-2
- $0.00
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Boc-D-Phg-OH
33125-05-2
- 98%
- Sichuan HongRi Pharma-Tech Co.,Ltd
-
- Boc-D-Phenylglycine
33125-05-2
- 98%
- Henan Aochuang Chemical Co.,Ltd.
