(3-bromopyridin-2-yl)methanol
- CAS No.
- 52378-64-0
- Chemical Name:
- (3-bromopyridin-2-yl)methanol
- Synonyms
- 3-Bromo-2-hydroxymethylpyridine;3-Bromopyridine-2-methanol;3-BroMo-2-pyridineMethanol;(3-bromo-2-pyridyl)methanol;2-PyridineMethanol, 3-broMo-;(3-bromopyridin-2-yl)methanol;2-Hydroxymethyl-3-bromopyridine;3-Bromo pyridine-2-yl) methanol;(3-bromopyridin-2-yl)methanol ISO 9001：2015 REACH;(3-Bromopyridin-2-yl)methanol, 3-Bromo-alpha-hydroxy-2-picoline
- CBNumber:
- CB12106109
- Molecular Formula:
- C6H6BrNO
- Molecular Weight:
- 188.02
- MDL Number:
- MFCD03095348
- MOL File:
- 52378-64-0.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| (3-Bromo-pyridin-2-yl)-methanol 97% | AS123949 | 1g | $23 |
| (3-Bromo-pyridin-2-yl)-methanol 97% | AS123949 | 5g | $40 |
| (3-Bromo-pyridin-2-yl)-methanol 97% | AS123949 | 25g | $136 |
| (3-Bromopyridin-2-yl)methanol 97% | B42889 | 250mg | $12 |
| (3-Bromopyridin-2-yl)methanol 97% | B42889 | 1g | $18 |
| More product size | |||
| Boiling point | 260.9±25.0 °C(Predicted) |
|---|---|
| Density | 1.668±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,2-8°C |
| pka | 12.75±0.10(Predicted) |
| Appearance | Off-white to brown Solid |
| InChI | InChI=1S/C6H6BrNO/c7-5-2-1-3-8-6(5)4-9/h1-3,9H,4H2 |
| InChIKey | FTTLCYCJDYIEFO-UHFFFAOYSA-N |
| SMILES | C1(CO)=NC=CC=C1Br |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302+H312+H332 |
| Precautionary statements | P260-P280 |
| RIDADR | UN2811 |
| HS Code | 2933399990 |
(3-bromopyridin-2-yl)methanol price More Price(61)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Activate Scientific | AS123949 | (3-Bromo-pyridin-2-yl)-methanol 97% | 52378-64-0 | 1g | $23 | 2026-06-04 | Buy |
| Activate Scientific | AS123949 | (3-Bromo-pyridin-2-yl)-methanol 97% | 52378-64-0 | 5g | $40 | 2026-06-04 | Buy |
| Activate Scientific | AS123949 | (3-Bromo-pyridin-2-yl)-methanol 97% | 52378-64-0 | 25g | $136 | 2026-06-04 | Buy |
| Synthonix | B42889 | (3-Bromopyridin-2-yl)methanol 97% | 52378-64-0 | 250mg | $12 | 2026-05-06 | Buy |
| Synthonix | B42889 | (3-Bromopyridin-2-yl)methanol 97% | 52378-64-0 | 1g | $18 | 2026-05-06 | Buy |
(3-bromopyridin-2-yl)methanol Chemical Properties,Uses,Production
Description
(3-bromopyridin-2-yl)methanol is a heterocyclic compound containing hydroxymethyl and bromine functional groups. It is primarily used as a synthetic intermediate. This compound can participate in electrophilic substitution, cross-coupling and redox reactions to construct complex bioactive molecules. The bromine atom at the 3-position is an excellent reaction site for the introduction of aryl, alkenyl or alkynyl groups via the Suzuki–Miyaura coupling reaction.
Chemical Properties
(3-bromopyridin-2-yl)methanol is a solid,it is stable under recommended temperatures and pressures.It can react with strong oxidizing agents.
Uses
(3-bromopyridin-2-yl)methanol is commonly used as an intermediate in organic and pharmaceutical synthesis.
Hazard
(3-bromopyridin-2-yl)methanol is toxicity if swallowed. Skin contact with it may result in inflammation characterized by itching, scaling, reddening, blistering, pain or dryness. Eye contact may result in redness, pain or severe eye damage.
Synthesis
405174-97-2
52378-64-0
General procedure for the synthesis of 3-bromo-2-hydroxymethylpyridine from 3-bromopyridine-2-carboxaldehyde: Preparation of (3-bromopyridin-2-yl)methanol (B5.2) (0363): 3-bromopyridine-2-carboxaldehyde (B5.1) (1 g, 5.4 mmol) was dissolved in a mixture of solvents of MeOH (20 mL) and THF (10 mL) and cooled to 0 °C. NaBH4 (0.82 g, 21.6 mmol) was added in batches under stirring. The reaction mixture was gradually warmed to room temperature and stirred continuously for 4 hours. Upon completion of the reaction, the mixture was concentrated to remove most of the solvent and subsequently diluted with deionized water (40 mL). Extraction was carried out with dichloromethane (DCM, 40 mL x 3) and the organic layers were combined and washed with saturated brine. The organic layer was dried over anhydrous Na2SO4, filtered and concentrated to afford the target product 3-bromo-2-hydroxymethylpyridine (1 g, 99% yield) as a white solid.LC-MS detection: [M + H]+ = 190.0.
References
[1] Patent: US2016/176882, 2016, A1. Location in patent: Paragraph 0361; 0363
[2] Patent: WO2017/221100, 2017, A1. Location in patent: Paragraph 00171
[3] Patent: WO2017/221092, 2017, A1. Location in patent: Paragraph 00169
(3-bromopyridin-2-yl)methanol Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20122 | 58 |
| Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 | sales@frappschem.com | China | 880 | 50 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 14014 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Changzhou Ditong Chemical Co.,Ltd | +86-0519-88298848 | info@edengenechem.com | China | 2165 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10000 | 58 |
View Lastest Price from (3-bromopyridin-2-yl)methanol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-12-01 | (3-bromopyridin-2-yl)methanol
52378-64-0
|
1KG | 98.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2025-11-18 | (3-bromopyridin-2-yl)methanol
52378-64-0
|
$1.10 | 1g | 99.00% | 100 Tons min | Dideu Industries Group Limited | |
 |
2025-09-25 | (3-bromopyridin-2-yl)methanol
52378-64-0
|
$3.00 | 1KG | 98% | Henan Fengda Chemical Co., Ltd |
-
- (3-bromopyridin-2-yl)methanol
52378-64-0
- 98.0%
- Shaanxi Dideu New Materials Co. Ltd
-
- (3-bromopyridin-2-yl)methanol
52378-64-0
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- (3-bromopyridin-2-yl)methanol
52378-64-0
- $3.00
- 98%
- Henan Fengda Chemical Co., Ltd
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