1-Piperidinepropanol
- CAS No.
- 104-58-5
- Chemical Name:
- 1-Piperidinepropanol
- Synonyms
- AKOS BC-0904;BUTTPARK 75\06-09;Piperidinepropanol;1-Piperidinepropano;1-PIPERIDINEPROPANOL;3-Piperidinopropanol;1-Piperidinopropanol;piperidine-1-propanol;3-PIPERIDINOPROPAN-1-OL;3-Piperidino-1-propanol
- CBNumber:
- CB1212017
- Molecular Formula:
- C8H17NO
- Molecular Weight:
- 143.23
- MDL Number:
- MFCD00023781
- MOL File:
- 104-58-5.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 1-Piperidinepropanol 97% | 152935 | 5g | $150 |
| 3-(Piperidin-1-yl)propan-1-ol min. 98.0 % | P2973 | 1G | $32 |
| 3-(Piperidin-1-yl)propan-1-ol min. 98.0 % | P2973 | 5G | $95 |
| 1-Piperidinepropanol | TRC-P482403-5G | 5g | $147 |
| 1-Piperidinepropanol | TRC-P482403-1G | 1g | $70 |
| More product size | |||
| Boiling point | 94-95 °C/0.5 mmHg (lit.) |
|---|---|
| Density | 0.944 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | 208 °F |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| pka | 15.12±0.10(Predicted) |
| form | liquid |
| color | Colourless to light yellow |
| InChI | InChI=1S/C8H17NO/c10-8-4-7-9-5-2-1-3-6-9/h10H,1-8H2 |
| InChIKey | PLRXAFVBCHEMGD-UHFFFAOYSA-N |
| SMILES | N1(CCCO)CCCCC1 |
| CAS DataBase Reference | 104-58-5(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| NIST Chemistry Reference | 1-Piperidinepropanol(104-58-5) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 |
| target organs | Respiratory system |
| PPE | dust mask type N95 (US), Eyeshields, Gloves |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| RTECS | TN2414500 |
| HS Code | 2933399990 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
1-Piperidinepropanol price More Price(55)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 152935 | 1-Piperidinepropanol 97% | 104-58-5 | 5g | $150 | 2023-06-20 | Buy |
| TCI Chemical | P2973 | 3-(Piperidin-1-yl)propan-1-ol min. 98.0 % | 104-58-5 | 1G | $32 | 2026-04-30 | Buy |
| TCI Chemical | P2973 | 3-(Piperidin-1-yl)propan-1-ol min. 98.0 % | 104-58-5 | 5G | $95 | 2026-04-30 | Buy |
| TRC | TRC-P482403-5G | 1-Piperidinepropanol | 104-58-5 | 5g | $147 | 2026-06-03 | Buy |
| TRC | TRC-P482403-1G | 1-Piperidinepropanol | 104-58-5 | 1g | $70 | 2026-06-03 | Buy |
1-Piperidinepropanol Chemical Properties,Uses,Production
Uses
Reactant in: Mitsunobu reaction of intramolecular nitrile oxide-alkene cycloadditions1 Suzuki-coupling2Reactant for synthesis of: Histamine H3 receptor antagonists3 Protein lysine methyltransferase G9a inhibitors4 Serotonin-4 receptors antagonists5 Checkpoint kinase Chk2 inhibitors6
Uses
1-Piperidinepropanol is used in preparation of Ionizable Amine lipids for lipid Nanoparticle compounds that deliver Nucleic Acids.
Synthesis
23573-93-5
104-58-5
Step 2: Synthesis of 3-(piperidin-1-yl)propanol Anhydrous tetrahydrofuran (80 mL) was added to a dry three-necked flask and the reaction system was cooled to 0 °C. Lithium aluminum hydride (3.5 g, 93.4 mmol) was added to the flask in batches followed by slow dropwise addition of a tetrahydrofuran solution of methyl 3-(piperidin-1-yl)propionate (8.0 g, 46.7 mmol). After the dropwise addition was completed, the reaction mixture was gradually warmed up to room temperature and the reaction was continued with stirring for 2 hours. Upon completion of the reaction, the mixture was re-cooled to 0°C. Purified water (10 mL), 15% aqueous NaOH solution (10 mL) and purified water (30 mL) were added sequentially to the cooled mixture to quench the reaction. The resulting white solid was removed by filtration and the filtrate was concentrated to afford a yellow oily product, 3-(piperidin-1-yl)propanol (4.0 g), which could be used in subsequent steps without further purification.
References
[1] Tetrahedron, 2007, vol. 63, # 52, p. 12903 - 12911
[2] Patent: EP3181554, 2017, A1. Location in patent: Paragraph 0253
1-Piperidinepropanol Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Changzhou Ditong Chemical Co.,Ltd | +86-0519-88298848 | info@edengenechem.com | China | 2165 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10000 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52705 | 58 |
| Jiangxi Huihe Chemical Co., Ltd. | +86-19189228086 +8618858568638 | wuzhouding@huihecrop.com | China | 886 | 58 |
View Lastest Price from 1-Piperidinepropanol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2021-08-12 | 1-Piperidinepropanol
104-58-5
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2021-07-02 | 1-Piperidinepropanol 97%
104-58-5
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2019-12-23 | 1-Piperidinepropanol
104-58-5
|
$1.00 | 1g | 96%-98% | 1000KGS | Career Henan Chemical Co |
-
- 1-Piperidinepropanol
104-58-5
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 1-Piperidinepropanol 97%
104-58-5
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 1-Piperidinepropanol
104-58-5
- $1.00
- 96%-98%
- Career Henan Chemical Co
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