Flumatinib mesylate
- CAS No.
- 895519-91-2
- Chemical Name:
- Flumatinib mesylate
- Synonyms
- CS-1023;HHGV678 mesylate;FluMatinib Mesylate;Flumatinib mesylate (HHGV-678);Flumatinib mesylate, 10 mM in DMSO;N-(6-Methyl-5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)pyridin-3-yl)-4-((4-methylpiperazin-1-yl);N-(6-Methyl-5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)pyridin-3-yl)-4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamide methanesulfonate;methanesulfonic acid,4-[(4-methylpiperazin-1-yl)methyl]-N-[6-methyl-5-[(4-pyridin-3-ylpyrimidin-2-yl)amino]pyridin-3-yl]-3-(trifluoromethyl)benzamide;HHGV-678,PDGFRβ,HHGV678,c-Abl,Bcr-Abl,Platelet-derived growth factor receptor,PDGFR,HHGV 678,SCFR,Flumatinib mesylate,c-Kit,Flumatinib,CD117,Inhibitor,inhibit;BenzaMide, 4-[(4-Methyl-1-piperazinyl)Methyl]-N-[6-Methyl-5-[[4-(3-pyridinyl)-2-pyriMidinyl]aMino]-3-pyridinyl]-3-(trifluoroMethyl)-, MonoMethanesulfonate (9CI)
- CBNumber:
- CB12667200
- Molecular Formula:
- C30H33F3N8O4S
- Molecular Weight:
- 658.6944296
- MDL Number:
- MFCD28053502
- MOL File:
- 895519-91-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Flumatinib mesylate 99.80% | CS-1826 | 5mg | $108 |
| Flumatinib mesylate 99.80% | CS-1826 | 10mg | $179 |
| Flumatinib mesylate 99.80% | CS-1826 | 25mg | $347 |
| Flumatinib mesylate 99.80% | CS-1826 | 50mg | $542 |
| Flumatinib mesylate 99.80% | CS-1826 | 100mg | $867 |
| More product size | |||
| storage temp. | Store at -20°C |
|---|---|
| solubility | H2O : 50 mg/mL (75.91 mM; Need ultrasonic)DMSO : 50 mg/mL (75.91 mM; Need ultrasonic) |
| form | Powder |
| color | Light brown to yellow |
| FDA UNII | 95Y8L63NBC |
| NCI Drug Dictionary | flumatinib mesylate |
Flumatinib mesylate price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-1826 | Flumatinib mesylate 99.80% | 895519-91-2 | 5mg | $108 | 2026-06-04 | Buy |
| ChemScene | CS-1826 | Flumatinib mesylate 99.80% | 895519-91-2 | 10mg | $179 | 2026-06-04 | Buy |
| ChemScene | CS-1826 | Flumatinib mesylate 99.80% | 895519-91-2 | 25mg | $347 | 2026-06-04 | Buy |
| ChemScene | CS-1826 | Flumatinib mesylate 99.80% | 895519-91-2 | 50mg | $542 | 2026-06-04 | Buy |
| ChemScene | CS-1826 | Flumatinib mesylate 99.80% | 895519-91-2 | 100mg | $867 | 2026-06-04 | Buy |
Flumatinib mesylate Chemical Properties,Uses,Production
Uses
Flumatinib (HHGV678) mesylate is an orally active and selective inhibitor of Bcr-Abl. Flumatinib mesylate inhibits c-Abl, PDGFRβ and c-Kit with IC50 values of 1.2, 307.6 and 665.5 nM, respectively. Flumatinib mesylate inhibits Bcr-Abl autophosphorylation and Stat5 and Erk1/2 phosphorylation. Flumatinib mesylate inhibits tumor growth in chronic myelogenous leukemia model[1][2].
Synthesis
Synthesis of Flumatinib Mesylate
in vivo
Flumatinib mesylate (HH-GV-678) (18-75 mg/kg; p.o.; Twice daily, for 14 days.) inhibits tumor growth in nude mice[1].
| Animal Model: | Nude mice (subcutaneously injecting K562 cells)[1] |
| Dosage: | 18.75, 37.5, 75 mg/kg |
| Administration: | Oral administration; Twice daily, for 14 days. |
| Result: | Inhibited the growth of K562 xenografts in a dose-dependent manner and induced regression in all tumors at a daily dose of 75 mg/kg for nine days. |
IC 50
PDGFRβ: 307.6 nM (IC50); c-Abl: 1.2 nM (IC50)
References
[1] Luo H, et al. HH-GV-678, a novel selective inhibitor of Bcr-Abl, outperforms imatinib and effectively overrides imatinib resistance. Leukemia. 2010 Oct;24(10):1807-9. DOI:10.1038/leu.2010.169
[2] Zhao J, et al. Flumatinib, a selective inhibitor of BCR-ABL/PDGFR/KIT, effectively overcomes drug resistance of certain KIT mutants. Cancer Sci. 2013 Nov 10. DOI:10.1111/cas.12320
Flumatinib mesylate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19853 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39039 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7552 | 61 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4861 | 58 |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2782 | 58 |
| Supplier | Advantage |
|---|---|
| ATK CHEMICAL COMPANY LIMITED | 60 |
| career henan chemical co | 58 |
| BOC Sciences | 58 |
| InvivoChem | 58 |
| TargetMol Chemicals Inc. | 58 |
| Aladdin Scientific | 58 |
| Amadis Chemical Company Limited | 58 |
| Haoyuan Chemexpress Co., Ltd. | 61 |
| MedChemexpress LLC | 58 |
| AdooQ BioScience, LLC | 58 |
Related articles
- How to synthesize Flumatinib mesylate?
- Flumatinib mesylate, also known as HHGV-678, is a selective inhibitor of the tyrosine kinase BCR-ABL1. The drug was discovered....
- Jan 19，2024
View Lastest Price from Flumatinib mesylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
![BenzaMide, 4-[(4-Methyl-1-piperazinyl)Methyl]-N-[6-Methyl-5-[[4-(3-pyridinyl)-2-pyriMidinyl]aMino]-3-pyridinyl]-3-(trifluoroMethyl)-, MonoMethanesulfonate (9CI) pictures](https://img.chemicalbook.com/ProductImageEN/2020-1/Small/e67b1ebe-50bc-46b6-8b85-a27e8b807a21.png) |
2020-01-05 | BenzaMide, 4-[(4-Methyl-1-piperazinyl)Methyl]-N-[6-Methyl-5-[[4-(3-pyridinyl)-2-pyriMidinyl]aMino]-3-pyridinyl]-3-(trifluoroMethyl)-, MonoMethanesulfonate (9CI)
895519-91-2
|
$1.00 | 1KG | 95--99% | 1ton | Career Henan Chemical Co |
-
- BenzaMide, 4-[(4-Methyl-1-piperazinyl)Methyl]-N-[6-Methyl-5-[[4-(3-pyridinyl)-2-pyriMidinyl]aMino]-3-pyridinyl]-3-(trifluoroMethyl)-, MonoMethanesulfonate (9CI)
895519-91-2
- $1.00
- 95--99%
- Career Henan Chemical Co
