METHYL 4-AMINO-3-CHLOROBENZOATE
- CAS No.
- 84228-44-4
- Chemical Name:
- METHYL 4-AMINO-3-CHLOROBENZOATE
- Synonyms
- AKOS BB-3098;TIMTEC-BB SBB003712;METHYL 4-AMINO-3-CHLOROBENZOATE;Methyl4-amino-3-chlorobenzoate98%;Methyl 4-AMino-3-Chloro Benzonate;Methyl 4-amino-3-chlorobenzoate 98%;2-Chloro-4-(methoxycarbonyl)aniline;Methyl 4-amino-3-chlorobenzoate,97%;Methyl 4-amino-3-chlorophenylacetate;Methyl 4-aMino-3-chlorobenzoate, 97% 5GR
- CBNumber:
- CB1302093
- Molecular Formula:
- C8H8ClNO2
- Molecular Weight:
- 185.61
- MDL Number:
- MFCD01320686
- MOL File:
- 84228-44-4.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Methyl 4-amino-3-chlorobenzoate 97% | 655902 | 1g | $73.9 |
| Methyl 4-amino-3-chlorobenzoate 97% | 655902 | 5g | $215 |
| Methyl 4-Amino-3-chlorobenzoate >97.0%(GC) | M2698 | 1g | $36 |
| Methyl 4-Amino-3-chlorobenzoate >97.0%(GC) | M2698 | 5g | $126 |
| 4-Amino-3-chlorobenzoic acid methyl ester 98% | AS87941 | 1g | $21 |
| More product size | |||
| Melting point | 107-111 °C |
|---|---|
| Boiling point | 321.6±22.0 °C(Predicted) |
| Density | 1.2797 (rough estimate) |
| refractive index | 1.5560 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| form | Crystalline Powder |
| pka | 0.52±0.10(Predicted) |
| color | Beige-brown |
| InChI | 1S/C8H8ClNO2/c1-12-8(11)5-2-3-7(10)6(9)4-5/h2-4H,10H2,1H3 |
| InChIKey | WKVJBYKFGNVWLM-UHFFFAOYSA-N |
| SMILES | COC(=O)c1ccc(N)c(Cl)c1 |
| CAS DataBase Reference | 84228-44-4(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P501 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Faceshields, Gloves | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22 | |||||||||
| Safety Statements | 36/37 | |||||||||
| WGK Germany | 2 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 29224985 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral | |||||||||
| NFPA 704 |
|
METHYL 4-AMINO-3-CHLOROBENZOATE price More Price(59)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 655902 | Methyl 4-amino-3-chlorobenzoate 97% | 84228-44-4 | 1g | $73.9 | 2023-06-20 | Buy |
| Sigma-Aldrich | 655902 | Methyl 4-amino-3-chlorobenzoate 97% | 84228-44-4 | 5g | $215 | 2023-06-20 | Buy |
| TCI Chemical | M2698 | Methyl 4-Amino-3-chlorobenzoate >97.0%(GC) | 84228-44-4 | 1g | $36 | 2026-04-30 | Buy |
| TCI Chemical | M2698 | Methyl 4-Amino-3-chlorobenzoate >97.0%(GC) | 84228-44-4 | 5g | $126 | 2026-04-30 | Buy |
| Activate Scientific | AS87941 | 4-Amino-3-chlorobenzoic acid methyl ester 98% | 84228-44-4 | 1g | $21 | 2026-06-04 | Buy |
METHYL 4-AMINO-3-CHLOROBENZOATE Chemical Properties,Uses,Production
Chemical Properties
beige-brown crystals or crystalline powder
Synthesis
67-56-1
2486-71-7
84228-44-4
Concentrated sulfuric acid (2.00 mL) was added slowly and dropwise to a stirred solution of 3-chloro-4-aminobenzoic acid (2.00 g, 11.7 mmol) in methanol (20.0 mL) at 0 °C. The reaction mixture was warmed to 80 °C and kept stirring for 6 hours. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently concentrated under reduced pressure. The concentrated residue was diluted with saturated aqueous sodium bicarbonate and extracted with ethyl acetate (2 x 50 mL). The organic phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give methyl 4-amino-3-chlorobenzoate (2.10 g, 97% yield). The product was confirmed by NMR hydrogen spectroscopy (400 MHz, DMSO-d6): δ 7.70 (d, J = 1.6Hz, 1H), 7.58 (dd, J = 8.4, 2.0Hz, 1H), 6.77 (d, J = 8.8Hz, 1H), 6.24 (s, 2H), 3.73 (s, 3H).
References
[1] Patent: WO2011/128251, 2011, A1. Location in patent: Page/Page column 203
[2] Patent: US2011/257151, 2011, A1. Location in patent: Page/Page column 75
[3] Patent: WO2018/157190, 2018, A1. Location in patent: Paragraph 0337
[4] Journal of Cellular Biochemistry, 2017, vol. 118, # 8, p. 2420 - 2429
[5] Journal of Medicinal Chemistry, 2018, vol. 61, # 3, p. 666 - 680
METHYL 4-AMINO-3-CHLOROBENZOATE Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | sales@win-winchemical.com | China | 14304 | 58 |
| Changzhou Anxuan Chemical Co., Ltd | +86-0519-89882563 +86-18961279162 | andy@anxuanchem.com | China | 4327 | 58 |
| Henan Alfa Chemical Co., Ltd | +8615838112936 | sale03@alfachem.cn | China | 9796 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25356 | 58 |
| Suzhou Victorypharm Co.,Ltd. | +86-13916956214 | sales@victory-pharm.com | China | 1299 | 58 |
View Lastest Price from METHYL 4-AMINO-3-CHLOROBENZOATE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-08-12 | METHYL 4-AMINO-3-CHLOROBENZOATE
84228-44-4
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2019-07-14 | METHYL 4-AMINO-3-CHLOROBENZOATE
84228-44-4
|
$1.00 | 1KG | 99% | 100kg | Career Henan Chemical Co |
-
- METHYL 4-AMINO-3-CHLOROBENZOATE
84228-44-4
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- METHYL 4-AMINO-3-CHLOROBENZOATE
84228-44-4
- $1.00
- 99%
- Career Henan Chemical Co
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