3-Cyano-7-hydroxycoumarin
- CAS No.
- 19088-73-4
- Chemical Name:
- 3-Cyano-7-hydroxycoumarin
- Synonyms
- 3-CYANOUMBELLIFERONE;3-Cyanoumbelliferone>3-CYANO-7-HYDROXYCOUMARIN;3-Cyano-7-hydroxycoumarin 95+%;7-Hydroxy-2-oxochromene-3-carbonitrile;3-CYANOUMBELLIFERONE, FOR FLUORESCENCE*;7-hydroxy-2-oxo-2H-chromene-3-carbonitrile;3-Cyano-7-hydroxycoumarin *CAS 19088-73-4*;7-hydroxy-2-oxo-1-benzopyran-3-carbonitrile;3-Cyano-7-hydroxycoumarin ISO 9001：2015 REACH
- CBNumber:
- CB1344231
- Molecular Formula:
- C10H5NO3
- Molecular Weight:
- 187.15
- MDL Number:
- MFCD00037480
- MOL File:
- 19088-73-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 3-Cyanoumbelliferone BioReagent, suitable for fluorescence, ≥98.0% (TLC) | 28605 | 100mg | $174 |
| 3-Cyanoumbelliferone BioReagent, suitable for fluorescence, ≥98.0% (TLC) | 28605 | 500mg | $666 |
| 3-Cyanoumbelliferone >98.0%(GC) | C2834 | 1g | $78 |
| 3-Cyanoumbelliferone >98.0%(GC) | C2834 | 5g | $233 |
| 3-Cyanoumbelliferone ≥98% | CS-0009930 | 1g | $65 |
| More product size | |||
| Melting point | ≥250 °C(lit.) |
|---|---|
| Boiling point | 436.6±45.0 °C(Predicted) |
| Density | 1.50±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | DMF: soluble |
| form | powder to crystal |
| pka | 7.03 ± 0.20, most acidic, temperature: 25 °C |
| color | Yellow solid or powder |
| λmax | 408 nm (Buffer pH 9); 408 nm (MeOH) |
| BRN | 153271 |
| Major Application | Electroluminescentdevice;laser dyes; modified polyester for foodcontainers/beverage bottles; monitoring of cationicphotopolymerization processes;textiles;thin films |
| Biological Applications | Detectingmicroorganisms,nucleic acids; inhibiting cellproliferation/tumor growth; reference standard foresters; ethers,phosphates substrates; asa substrate for measuring nucleic acid polymerasesactivity; treating viral or parasite infections |
| InChI | 1S/C10H5NO3/c11-5-7-3-6-1-2-8(12)4-9(6)14-10(7)13/h1-4,12H |
| InChIKey | IJQYTHQDUDCJEQ-UHFFFAOYSA-N |
| SMILES | Oc1ccc2C=C(C#N)C(=O)Oc2c1 |
| CAS DataBase Reference | 19088-73-4 |
| UNSPSC Code | 12352108 |
| NACRES | NA.32 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 20/21/22-36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 8 | |||||||||
| HS Code | 2932.20.4500 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Dermal Acute Tox. 4 Inhalation Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
3-Cyano-7-hydroxycoumarin price More Price(60)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 28605 | 3-Cyanoumbelliferone BioReagent, suitable for fluorescence, ≥98.0% (TLC) | 19088-73-4 | 100mg | $174 | 2026-04-30 | Buy |
| Sigma-Aldrich | 28605 | 3-Cyanoumbelliferone BioReagent, suitable for fluorescence, ≥98.0% (TLC) | 19088-73-4 | 500mg | $666 | 2026-04-30 | Buy |
| TCI Chemical | C2834 | 3-Cyanoumbelliferone >98.0%(GC) | 19088-73-4 | 1g | $78 | 2026-04-30 | Buy |
| TCI Chemical | C2834 | 3-Cyanoumbelliferone >98.0%(GC) | 19088-73-4 | 5g | $233 | 2026-04-30 | Buy |
| ChemScene | CS-0009930 | 3-Cyanoumbelliferone ≥98% | 19088-73-4 | 1g | $65 | 2026-06-04 | Buy |
3-Cyano-7-hydroxycoumarin Chemical Properties,Uses,Production
Uses
3-Cyanoumbelliferone is a calibration standard.
Uses
3-Cyano-7-hydroxycoumarin has been the most widely used fluorophores for preparing fluorogenic substrates.As a blue-fluorescent probe used as a reference standard.
Synthesis
105-56-6
95-01-2
19088-73-4
GENERAL METHOD: α-substituted ethyl acetate (1.0 mmol) and phenyl iododo diacetate (1.0 mmol) were dissolved in ethanol (5 mL) under continuous stirring conditions. After 10 min of reaction, benzaldehyde or salicylaldehyde (1.0 mmol) was added to the system and the reaction was continued with stirring until the appropriate time. The progress of the reaction was monitored by thin layer chromatography (TLC). After the TLC showed that the reaction was complete, the ethanol was evaporated under reduced pressure. Subsequently, the product was extracted with ethyl acetate and the organic phase was dried with anhydrous sodium sulfate (Na2SO4) and concentrated again under reduced pressure to remove the solvent. The resulting crude product was purified by recrystallization from a solvent mixture of ethyl acetate and hexane to finally obtain the target compound 7-hydroxy-2-oxochromene-3-carbonitrile (3a-3h and 4a-4r series derivatives).
References
[1] Synthetic Communications, 2005, vol. 35, # 6, p. 785 - 790
[2] Phosphorus, Sulfur and Silicon and the Related Elements, 2002, vol. 177, # 11, p. 2555 - 2559
[3] Tetrahedron Letters, 2017, vol. 58, # 32, p. 3183 - 3187
[4] Journal of Heterocyclic Chemistry, 2007, vol. 44, # 4, p. 867 - 870
[5] Journal of the Iranian Chemical Society, 2016, vol. 13, # 1, p. 149 - 153
3-Cyano-7-hydroxycoumarin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 13901 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 21169 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
View Lastest Price from 3-Cyano-7-hydroxycoumarin manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-11 | 3-Cyano-7-hydroxycoumarin
19088-73-4
|
$48.00 | 98.20% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-11-18 | 3-Cyano-7-hydroxycoumarin
19088-73-4
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2024-09-06 | 3-Cyano-7-hydroxycoumarin
19088-73-4
|
$2450.00 | 1g | 98 | 500 Kg | R&D Scientific Inc. |
-
- 3-Cyano-7-hydroxycoumarin
19088-73-4
- $48.00
- 98.20%
- TargetMol Chemicals Inc.
-
- 3-Cyano-7-hydroxycoumarin
19088-73-4
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 3-Cyano-7-hydroxycoumarin
19088-73-4
- $2450.00
- 98
- R&D Scientific Inc.
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