3,4-Difluoroaniline
- CAS No.
- 3863-11-4
- Chemical Name:
- 3,4-Difluoroaniline
- Synonyms
- 3,4-DIFLUOROBENZENAMINE;3,4-Difluoro-phenylamine;AKOS 91142;3,4-DIFLUOROANILINE;TIMTEC-BB SBB007915;3, 4-2 fluoro aniline;Linezolid Impurity 95;3,4-Difluoroaniline98%;3,4-Difluoroaniline>3,4-difluoro-benzenamin
- CBNumber:
- CB1398032
- Molecular Formula:
- C6H5F2N
- Molecular Weight:
- 129.11
- MDL Number:
- MFCD00007761
- MOL File:
- 3863-11-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 3,4-Difluoroaniline 99% | 270237 | 5g | $53.9 |
| 3,4-Difluoroaniline 99% | 270237 | 25g | $102 |
| 3,4-Difluoroaniline >98.0%(GC)(T) | D1809 | 25g | $98 |
| 3,4-Difluoroaniline >98.0%(GC)(T) | D1809 | 100g | $293 |
| 3,4-Difluoroaniline Asreported | 270635 | 50g | $333 |
| More product size | |||
| Melting point | 22°C |
|---|---|
| Boiling point | 77 °C/7 mmHg (lit.) |
| Density | 1.302 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | 185 °F |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| form | powder to lump to clear liquid |
| pka | 3+-.0.10(Predicted) |
| color | White or Colorless to Yellow |
| Specific Gravity | 1.302 |
| Water Solubility | SLIGHTLY SOLUBLE |
| BRN | 971235 |
| InChI | InChI=1S/C6H5F2N/c7-5-2-1-4(9)3-6(5)8/h1-3H,9H2 |
| InChIKey | AXNUZKSSQHTNPZ-UHFFFAOYSA-N |
| SMILES | C1(N)=CC=C(F)C(F)=C1 |
| CAS DataBase Reference | 3863-11-4(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | N4MC3Z4TRF |
| NIST Chemistry Reference | 3,4-Difluoroaniline(3863-11-4) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22-36/37/38-20/21/22 | |||||||||
| Safety Statements | 26-36-36/37/39 | |||||||||
| RIDADR | UN 2941 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | CX9871900 | |||||||||
| F | 8-10-23 | |||||||||
| Hazard Note | Irritant | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29214200 | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
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| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
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| Limited Quantities | 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
3,4-Difluoroaniline price More Price(73)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 270237 | 3,4-Difluoroaniline 99% | 3863-11-4 | 5g | $53.9 | 2026-04-30 | Buy |
| Sigma-Aldrich | 270237 | 3,4-Difluoroaniline 99% | 3863-11-4 | 25g | $102 | 2026-04-30 | Buy |
| TCI Chemical | D1809 | 3,4-Difluoroaniline >98.0%(GC)(T) | 3863-11-4 | 25g | $98 | 2026-04-30 | Buy |
| TCI Chemical | D1809 | 3,4-Difluoroaniline >98.0%(GC)(T) | 3863-11-4 | 100g | $293 | 2026-04-30 | Buy |
| Usbiological | 270635 | 3,4-Difluoroaniline Asreported | 3863-11-4 | 50g | $333 | 2026-06-03 | Buy |
3,4-Difluoroaniline Chemical Properties,Uses,Production
Chemical Properties
clear yellow to straw liquid after melting
Uses
3,4-Difluoroaniline was used in the synthesis of (3,4-disfluoro)phenylquione.
General Description
3,4-Difluoroaniline (3,4-DFA) was degraded, under aerobic conditions, by Pseudomonas fluorescens.
Synthesis
369-34-6
3863-11-4
The general procedure for the synthesis of 3,4-difluoroaniline from 3,4-difluoronitrobenzene was as follows: 200.0 g of 3,4-difluoronitrobenzene, 600.0 mL of toluene and 12.0 g of Pd/C catalyst were added to an autoclave at 25 °C to 35 °C. Hydrogen was passed into the reaction system, keeping the hydrogen pressure between 2.0 and 6.0 kg/cm2, and the reaction was carried out at 25 °C to 35 °C for 3 to 4 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) to ensure complete reaction. Upon completion of the reaction, the reaction mixture was sequentially depressurized and unloaded, filtered through a Hyflow bed, and the filter cake was washed with 200.0 mL of toluene. The filtrate was collected and vacuum distilled at less than 50 °C to remove the solvent. Finally, 152.0 g of crude 3,4-difluoroaniline was obtained in 93.8% yield and 95.85% purity by high performance liquid chromatography (HPLC).
References
[1] Patent: WO2015/68171, 2015, A1. Location in patent: Page/Page column 9; 16
[2] Tetrahedron Letters, 2010, vol. 51, # 5, p. 786 - 789
[3] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 2, p. 613 - 617
[4] ChemPlusChem, 2018, vol. 83, # 5, p. 375 - 382
[5] Synthesis, 2001, # 1, p. 81 - 84
3,4-Difluoroaniline Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
1of2
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81138252 +86-173 9270 1263 | 1057@dideu.com | China | 3958 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 +8613131129325 | sales1@chuanghaibio.com | China | 5220 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Hi-Tech Chemistry Corp | 0519-86626038 | yuhh@hitechem.com | CHINA | 810 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21585 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29812 | 58 |
| NINGBO INNO PHARMCHEM CO., LTD. | 13867897135 | sales@nbinno.com | CHINA | 923 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8615060885618 | sales@amoychem.com | China | 6366 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
View Lastest Price from 3,4-Difluoroaniline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-05-28 | 3,4-Difluoroaniline
3863-11-4
|
$10.50 | 1KG | 99% | 10 ton | Hebei Chuanghai Biotechnology Co,.LTD | |
 |
2025-04-04 | 3,4-Difluoroaniline
3863-11-4
|
1KG | 98% | 1ton | Henan Aochuang Chemical Co.,Ltd.
|
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2024-08-14 | 3,4-Difluoroaniline
3863-11-4
|
$1.00 | 1KG | 99% | 20T | Shaanxi Dideu Medichem Co. Ltd |
-
- 3,4-Difluoroaniline
3863-11-4
- $10.50
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
-
- 3,4-Difluoroaniline
3863-11-4
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 3,4-Difluoroaniline
3863-11-4
- $1.00
- 99%
- Shaanxi Dideu Medichem Co. Ltd
