Calcipotriene
- CAS No.
- 112828-00-9
- Chemical Name:
- Calcipotriene
- Synonyms
- CALCIPOTRIOL;Carpotriol;Calcipotrien;Calcipotriene;Calcipotriene API;Calcipotriene USP/EP/BP;Calcipotriene/calcipotriol;24-CYCLOPROPYL-(1ALPHA,3BETA,5Z,7E,22E,24S)-9,10-SECOCHOLA-5,7,10(19),22-TETRAENE-1,3,24-TRIOL;(1R,3S,5Z)-5-{2-[(4E)-1-[(2R,3E,5R)-5-CYCLOPROPYL-5-HYDROXYPENT-3-EN-2-YL]-7A-METHYL-HEXAHYDRO-1H-IN;(1r,3s,5z)-5-[(2e)-2-[1-[(e,2r,5r)-5-cyclopropyl-5-hydroxypent-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1h-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
- CBNumber:
- CB1412712
- Molecular Formula:
- C27H40O3
- Molecular Weight:
- 412.6
- MDL Number:
- MFCD00866630
- MOL File:
- 112828-00-9.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Calcipotriol (hydrate) ≥98% | 10009599 | 10mg | $56 |
| Calcipotriol (hydrate) ≥98% | 10009599 | 50mg | $252 |
| Calcipotriol 99% | AA01FZCT | 25mg | $550 |
| Calcipotriol 99% | AA01FZCT | 100mg | $925 |
| Calcipotriol 99% | AA01FZCT | 250mg | $1925 |
| More product size | |||
| InChIKey | LWQQLNNNIPYSNX-ONRIVJDHNA-N |
|---|---|
| SMILES | [C@@]12([H])CC[C@H]([C@H](C)/C=C/[C@@H](O)C3CC3)[C@@]1(C)CCC/C/2=C\C=C1\C[C@H](C[C@H](O)C\1=C)O |&1:0,4,5,9,14,24,26,r| |
| CAS DataBase Reference | 112828-00-9(CAS DataBase Reference) |
| FDA UNII | 143NQ3779B |
| NCI Drug Dictionary | calcipotriene |
| ATC code | D05AX02,D05AX52 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H311-H301-H331 |
| Precautionary statements | P264-P270-P301+P310-P321-P330-P405-P501-P261-P271-P304+P340-P311-P321-P403+P233-P405-P501-P280-P302+P352-P312-P322-P361-P363-P405-P501 |
Calcipotriene price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 10009599 | Calcipotriol (hydrate) ≥98% | 112828-00-9 | 10mg | $56 | 2021-12-16 | Buy |
| Cayman Chemical | 10009599 | Calcipotriol (hydrate) ≥98% | 112828-00-9 | 50mg | $252 | 2021-12-16 | Buy |
| aablocks | AA01FZCT | Calcipotriol 99% | 112828-00-9 | 25mg | $550 | 2026-05-30 | Buy |
| aablocks | AA01FZCT | Calcipotriol 99% | 112828-00-9 | 100mg | $925 | 2026-05-30 | Buy |
| aablocks | AA01FZCT | Calcipotriol 99% | 112828-00-9 | 250mg | $1925 | 2026-05-30 | Buy |
Calcipotriene Chemical Properties,Uses,Production
Uses
Antipsoriatic.
Indications
Calcipotriene (calcipotriol) is a synthetic vitamin D3 derivative that is useful for
the treatment of patients with moderate plaque psoriasis. Its effects are comparable
with those of class II topical steroids, without the associated adverse effects.
Its mechanism of action involves both induction of terminal differentiation of
keratinocytes and inhibition of keratinocyte production. It should be applied to
the face with care, as this region is more susceptible to irritation, burning, and
itching, as seen in approximately 10% of patients. Other adverse effects include
erythema, peeling, xerosis, dermatitis, or worsening psoriasis in 1% to 10% of
patients. Fewer than 1% of patients experience hypercalcemia, atrophy, hyperpigmentation,
or folliculitis. Allergic contact dermatitis to calcipotriene has been
reported.
Most patients demonstrate improvement after 2 weeks; 70% of patients
improve after 8 weeks, with 10% showing complete clearing. It should be avoided
in patients with documented impairment in calcium metabolism, hypercalcemia,
vitamin D toxicity, or history of renal stones.
Calcipotriene may be used as an adjuvant with psoralens plus ultraviolet A
(PUVA) and ultraviolet B (UVB). Pretreatment with or subsequent addition of calcipotriol
to PUVA reduces the cumulative doses of UVA needed to achieve >75%
reduction in severity and distribution of psoriasis.
Definition
ChEBI: Calcipotriol is a seco-cholestane that is 26,27-cyclo-9,10-secocholesta-5,7,10,22-tetraene carrying additional hydroxy substituents at positions 1, 3 and 24. It is used (as its hydrate) in combination with betamethasone dipropionate, a corticosteroid, for the topical treatment of plaque psoriasis in adult patients. It has a role as a drug allergen and an antipsoriatic. It is a member of cyclopropanes, a secondary alcohol, a triol, a hydroxy seco-steroid and a seco-cholestane.
brand name
Dovonex (Leo).
Calcipotriene Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20122 | 58 |
| airuikechemical co., ltd. | +86-18353166132 | sales02@airuikechemical.com | China | 983 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21586 | 55 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8615060885618 | sales@amoychem.com | China | 6366 | 58 |
| Hebei shuoxi biotechnology co. LTD | +8613081092107 | CHINA | 964 | 58 | |
| Shenzhen Excellent Biotech Co., Ltd. | 13480692018 | ramyan@ex-biotech.com | CHINA | 954 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| Xi'an Yutbon Pharmaceutical Technology Co., Ltd | 029-81140587 +8618717328141 | sales@yutbon.com | China | 454 | 58 |
View Lastest Price from Calcipotriene manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-18 | Calcipotriene
112828-00-9
|
1KG | 98%min | 30tons/month | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2025-09-25 | Calcipotriene
112828-00-9
|
$2.00-10.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2025-08-21 | Calcipotriol
112828-00-9
|
1kg | 99.0%min. HPLC | 1000kg | HangZhou RunYan Pharma Technology Co.,LTD. |
-
- Calcipotriene
112828-00-9
- $0.00
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Calcipotriene
112828-00-9
- $2.00-10.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- Calcipotriol
112828-00-9
- $0.00
- 99.0%min. HPLC
- HangZhou RunYan Pharma Technology Co.,LTD.
