5-CHLOROISOQUINOLINE
- CAS No.
- 5430-45-5
- Chemical Name:
- 5-CHLOROISOQUINOLINE
- Synonyms
- NSC 13799;5-CHLORISOQUINOLIN;5-Chloroisoquinolin;5-CHLOROISOQUINOLINE;isoquinoline, 5-chloro;5-CHLOROISOQUINOLINE ISO 9001：2015 REACH
- CBNumber:
- CB1444694
- Molecular Formula:
- C9H6ClN
- Molecular Weight:
- 163.6
- MDL Number:
- MFCD02683295
- MOL File:
- 5430-45-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 5-Chloroisoquinoline 97% | 718238 | 1g | $173 |
| 5-Chloroisoquinoline | TRC-C367400-50MG | 50mg | $64 |
| 5-Chloroisoquinoline | TRC-C367400-250MG | 250mg | $91 |
| 5-Chloroisoquinoline | TRC-C367400-100MG | 100mg | $72 |
| 5-CHLOROISOQUINOLINE 97% | 57636 | 1G | $37 |
| More product size | |||
| Melting point | 69-73 °C |
|---|---|
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) |
| form | Solid |
| color | White |
| InChI | 1S/C9H6ClN/c10-9-3-1-2-7-6-11-5-4-8(7)9/h1-6H |
| InChIKey | PJHSMEMFNSINJE-UHFFFAOYSA-N |
| SMILES | Clc1cccc2cnccc12 |
| CAS DataBase Reference | 5430-45-5(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301-H318 |
| Precautionary statements | P280-P301+P310+P330-P305+P351+P338+P310 |
| Hazard Codes | Xn |
| Risk Statements | 22-41 |
| Safety Statements | 26-39 |
| RIDADR | UN 2811 |
| WGK Germany | 3 |
| HazardClass | 6.1 |
| PackingGroup | Ⅲ |
| HS Code | 2933499090 |
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
| Hazard Classifications | Acute Tox. 3 Oral Eye Dam. 1 |
5-CHLOROISOQUINOLINE price More Price(79)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 718238 | 5-Chloroisoquinoline 97% | 5430-45-5 | 1g | $173 | 2023-06-20 | Buy |
| TRC | TRC-C367400-50MG | 5-Chloroisoquinoline | 5430-45-5 | 50mg | $64 | 2026-06-03 | Buy |
| TRC | TRC-C367400-250MG | 5-Chloroisoquinoline | 5430-45-5 | 250mg | $91 | 2026-06-03 | Buy |
| TRC | TRC-C367400-100MG | 5-Chloroisoquinoline | 5430-45-5 | 100mg | $72 | 2026-06-03 | Buy |
| AstaTech | 57636 | 5-CHLOROISOQUINOLINE 97% | 5430-45-5 | 1G | $37 | 2026-04-30 | Buy |
5-CHLOROISOQUINOLINE Chemical Properties,Uses,Production
Chemical Properties
White Solid
Uses
5-Chloroisoquinoline (compound 42) is an inhibitor of SARM1 (Sterile alpha and toll/interleukin receptor (TIR) motif containing protein 1), an enzyme involved in axon degeneration that catalyzes multiple activities through a ternary complex mechanism. 5-Chloroisoquinoline can be used in the study of neurodegenerative diseases or axon degeneration[1].
Synthesis
119-65-3
5430-45-5
73075-59-9
Isoquinoline (1; 12.9 g, 0.1 mol, 1.0 equiv) was slowly added to concentrated H2SO4 (100 mL) pre-cooled to 0 °C under mechanical stirring. Under vigorous stirring, TCCA (12.8 g, 55 mmol, 1.65 eq.) was added in 4 batches while the reaction temperature was controlled not to exceed 10 °C. The reaction was carried out at 10 °C for a period of 2 hours. After the reaction mixture was stirred continuously at 10 °C for 24 h, the reaction progress was monitored by GC-MS. Subsequently, the reaction mixture was poured into crushed ice (~200 g) and the precipitate was collected by filtration. The pH of the filtrate was adjusted to 2 with concentrated ammonia solution, cooled sufficiently and filtered again. The filtrate was extracted with toluene (6 x 75 mL) to remove the by-product 5,8-dichloroisoquinoline (16). The aqueous phase was further alkalized with concentrated ammonia to pH 6, at which point the precipitate precipitated was filtered, washed with water and dried at room temperature. The final product was purified by recrystallization from methylcyclohexane in 15% yield. 5-Chloroisoquinoline was obtained as 7.60 g (45% yield), melting point 70-72 °C. IR (ATR): 1580, 1489, 1371, 1267, 1204, 1140, 1065, 984, 822, 750, 687, 628, 536 cm1. 1H NMR (400 MHz, CDCl3): δ= 9.27 (s, 1H), 8.64 (1H). 1H), 8.64 (d, J = 6.0 Hz, 1H), 8.02 (d, J = 6.0 Hz, 1H), 7.90 (d, J = 8.2 Hz, 1H), 7.77 (d, J = 7.5 Hz, 1H), 7.53 (t, J = 7.8 Hz, 1H).13C NMR (100 MHz, CDCl3): δ= 152.4, 143.9, 133.9, 133.5, 133.5 cm1. 1H NMR (400 MHz, CDCl3): δ= 152.4, 143.9, 143.9, 133.5 cm 143.9, 133.7, 131.0, 130.3, 129.4, 127.3, 126.7, 116.9.
References
[1] Inhibitors of SARM1. World Intellectual Property Organization, WO2019236879 A1 2019-12-12.
5-CHLOROISOQUINOLINE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569266 +86-17392581500 | 1015@dideu.com | China | 3991 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30224 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52704 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +86-571-86217390; +8618058761490 | info@gihichemicals.com | China | 49962 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43333 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 |
View Lastest Price from 5-CHLOROISOQUINOLINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-11-18 | 5-CHLOROISOQUINOLINE
5430-45-5
|
$1.10 | 1g | 99.00% | 100 Tons | Dideu Industries Group Limited |
-
- 5-CHLOROISOQUINOLINE
5430-45-5
- $1.10
- 99.00%
- Dideu Industries Group Limited
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