ChemicalBook >> CAS DataBase List >>(R)-3-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
(R)-3-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- CAS No.
- 138108-72-2
- Chemical Name:
- (R)-3-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- Synonyms
- (R)-1-Boc-3-pyrrolidineMethanol;N-Boc-D-^b-prolinol;N-Boc-D-beta-prolinol;N-Boc-D-^b-prolinol, 97+%;(R)-1-Boc-3-(hydroxyMethy...;(R)-N-BOC-PYRROLIDINE-3-METHANOL;[R]-1-BOC-3-Pyrrolidinemethanol 97%;(R)-1-Boc-3-hydroxymethylpyrrolidine;1-Boc-3(R)-(HydroxyMethyl)Pyrrolidine;(3R)-1-Boc-3-(hydroxymethyl)pyrrolidine
- CBNumber:
- CB1668944
- Molecular Formula:
- C10H19NO3
- Molecular Weight:
- 201.26
- MDL Number:
- MFCD03094725
- MOL File:
- 138108-72-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Last updated:2026-05-27 23:43:57
| Product description | Number | Pack Size | Price |
| (R)-3-Hydroxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester Asreported | 280132 | 500mg | $340 |
| (R)-3-Hydroxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester Asreported | 280132 | 1g | $496 |
| (R)-3-Hydroxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester Asreported | 280132 | 2g | $675 |
| (R)-3-Hydroxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester Asreported | 280132 | 5g | $917 |
| (R)-1-BOC-3-HYDROXYMETHYLPYRROLIDINE 97% | 55693 | 1G | $38 |
| More product size | |||
| Boiling point | 289.5±13.0 °C(Predicted) |
|---|---|
| Density | 1.089 |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| form | Oil |
| pka | 14.93±0.10(Predicted) |
| color | Clear Colourless to Pale Yellow |
| optical activity | Consistent with structure |
| Water Solubility | Slightly soluble in water |
| InChI | InChI=1S/C10H19NO3/c1-10(2,3)14-9(13)11-5-4-8(6-11)7-12/h8,12H,4-7H2,1-3H3/t8-/m1/s1 |
| InChIKey | HKIGXXRMJFUUKV-MRVPVSSYSA-N |
| SMILES | N1(C(OC(C)(C)C)=O)CC[C@@H](CO)C1 |
| CAS DataBase Reference | 138108-72-2 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| HS Code | 2933998090 | |||||||||
| NFPA 704 |
|
(R)-3-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER price More Price(87)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 280132 | (R)-3-Hydroxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester Asreported | 138108-72-2 | 500mg | $340 | 2026-06-03 | Buy |
| Usbiological | 280132 | (R)-3-Hydroxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester Asreported | 138108-72-2 | 1g | $496 | 2026-06-03 | Buy |
| Usbiological | 280132 | (R)-3-Hydroxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester Asreported | 138108-72-2 | 2g | $675 | 2026-06-03 | Buy |
| Usbiological | 280132 | (R)-3-Hydroxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester Asreported | 138108-72-2 | 5g | $917 | 2026-06-03 | Buy |
| AstaTech | 55693 | (R)-1-BOC-3-HYDROXYMETHYLPYRROLIDINE 97% | 138108-72-2 | 1G | $38 | 2026-04-30 | Buy |
(R)-3-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Chemical Properties,Uses,Production
Uses
It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuffs.
Synthesis
72925-16-7
138108-72-2
Borane-THF complex (1.0 M, 17 mL, 16.9 mmol) was added slowly and dropwise to a stirred solution of (R)-1-(tert-butoxycarbonyl)pyrrolidine-3-carboxylic acid (1.21 g, 5.6 mmol) in tetrahydrofuran (THF, 30 mL) at 0 °C. The reaction mixture was gradually warmed to room temperature over 30 minutes, followed by heating at 45 °C for 1 hour and then at 55 °C for 90 minutes. Upon completion of the reaction, the mixture was cooled to 0 °C and quenched by careful addition of 3N hydrochloric acid (30 mL). After stirring for 20 min at room temperature, the reaction mixture was extracted with ether (Et2O, 50 mL). The organic layer was washed sequentially with saturated aqueous sodium bicarbonate (NaHCO3, 20 mL) and brine (20 mL), dried over anhydrous sodium sulfate (Na2SO4), filtered, and concentrated under reduced pressure to afford (R)-tert-butyl-3-(hydroxymethyl)pyrrolidine-1-carboxylate (1.1 g, 91% yield) as a colorless oil.
References
[1] Patent: WO2011/150198, 2011, A1. Location in patent: Page/Page column 151
[2] Patent: WO2010/45212, 2010, A2. Location in patent: Page/Page column 299
[3] Patent: US2013/184313, 2013, A1. Location in patent: Paragraph 1541
(R)-3-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
Global( 187)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Chembon Pharmaceutical Co., Ltd. | +86-28-8425-2981 | CHINA | 722 | 55 | |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| HaBo Hong Kong Co., Limited. | +86-25-18512596065 | info@habotech.com | CHINA | 933 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
View Lastest Price from (R)-3-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-04 | (R)-3-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
138108-72-2
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | ||
 |
2019-07-06 | (R)-3-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
138108-72-2
|
$1.00 | 1KG | 95% | 500kg | Career Henan Chemical Co | |
 |
2019-07-06 | (R)-3-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
138108-72-2
|
$1.00 | 1KG | 95% | 200KG | Career Henan Chemical Co |
-
- (R)-3-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
138108-72-2
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- (R)-3-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
138108-72-2
- $1.00
- 95%
- Career Henan Chemical Co
-
- (R)-3-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
138108-72-2
- $1.00
- 95%
- Career Henan Chemical Co
138108-72-2((R)-3-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER)Related Search:
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(R)-3-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
(R)-N-BOC-PYRROLIDINE-3-METHANOL
(3R)-3-(Hydroxymethyl)pyrrolidine-1-carboxylic acid tert-butyl ester
tert-butyl (3R)-3-(hydroxyMethyl)pyrrolidine-1-carboxylate
N-Boc-D-^b-prolinol, 97+%
1-Boc-3(R)-(HydroxyMethyl)Pyrrolidine
(R)-1-Boc-3-(hydroxyMethy...
(R)-3-hydroxyMethyl-pyrrolidine-1-carboxylic
(3R)-N-tert-butyloxycarbonyl-3-hydroxymethylpyrrolidine
1-Pyrrolidinecarboxylic acid, 3-(hydroxymethyl)-, 1,1-dimethylethyl ester, (3R)-
N-Boc-D-^b-prolinol
tert-butyl(R)-3-(hydroxymethyl)pyrrolidine-1-carboxylate
N-Boc-D-beta-prolinol
(3R)-1-Boc-3-(hydroxymethyl)pyrrolidine
[R]-1-BOC-3-Pyrrolidinemethanol 97%
(R)-3-hydroxymethyl-pyrrolidine-1-carboxylic acid Tert-Butyl...
(R)-1-Boc-3-pyrrolidineMethanol
1,1-Dimethylethyl (3R)-3-(hydroxymethyl)-1-pyrrolidinecarboxylate
138108-72-2
Heterocycle-other series
pharmacetical
