4-Amino-3-hydroxybenzoic acid
- CAS No.
- 2374-03-0
- Chemical Name:
- 4-Amino-3-hydroxybenzoic acid
- Synonyms
- 4-Amino-3-hydroxybenzoic acid USP/EP/BP;3-Hydroxy PABA;3-hydroxy-4-AMino acid;Oxybuprocaine Impurity 3;Oxybuprocaine EP Impurity C;3-HYDROXY-4-AMINOBENZOIC ACID;4-AMINO-3-HYDROXYBENZOIC ACID;3-hydroxy-4-aminobenzoic Acids;BENZOIC ACID, 4-AMINO-3-HYDROXY-;4-Amino-3-hydroxybenzoic Acid >
- CBNumber:
- CB1733439
- Molecular Formula:
- C7H7NO3
- Molecular Weight:
- 153.14
- MDL Number:
- MFCD00017094
- MOL File:
- 2374-03-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 4-Amino-3-hydroxybenzoic acid 97% | 339598 | 5g | $78.3 |
| 4-Amino-3-hydroxybenzoic acid 97% | 339598 | 25g | $166 |
| 4-Amino-3-hydroxybenzoic Acid >98.0%(HPLC)(T) | A1194 | 5g | $48 |
| 4-Amino-3-hydroxybenzoic Acid >98.0%(HPLC)(T) | A1194 | 25g | $125 |
| 4-Amino-3-hydroxybenzoic acid Asreported | 259979 | 2g | $292 |
| More product size | |||
| Melting point | 211-215 °C (lit.) |
|---|---|
| Boiling point | 385.7±37.0 °C(Predicted) |
| Density | 1.028 |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 4.74±0.10(Predicted) |
| form | Crystalline Powder |
| color | Yellow-brown to brown |
| Water Solubility | Soluble in chloroform, and aqeous ethanol, water (Partly miscible) |
| BRN | 509859 |
| Major Application | peptide synthesis |
| InChI | InChI=1S/C7H7NO3/c8-5-2-1-4(7(10)11)3-6(5)9/h1-3,9H,8H2,(H,10,11) |
| InChIKey | NFPYJDZQOKCYIE-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C1=CC=C(N)C(O)=C1 |
| CAS DataBase Reference | 2374-03-0(CAS DataBase Reference) |
| UNSPSC Code | 12352106 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 36/37/38-22 | |||||||||
| Safety Statements | 26-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 29225090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
4-Amino-3-hydroxybenzoic acid price More Price(85)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 339598 | 4-Amino-3-hydroxybenzoic acid 97% | 2374-03-0 | 5g | $78.3 | 2026-04-30 | Buy |
| Sigma-Aldrich | 339598 | 4-Amino-3-hydroxybenzoic acid 97% | 2374-03-0 | 25g | $166 | 2026-04-30 | Buy |
| TCI Chemical | A1194 | 4-Amino-3-hydroxybenzoic Acid >98.0%(HPLC)(T) | 2374-03-0 | 5g | $48 | 2026-04-30 | Buy |
| TCI Chemical | A1194 | 4-Amino-3-hydroxybenzoic Acid >98.0%(HPLC)(T) | 2374-03-0 | 25g | $125 | 2026-04-30 | Buy |
| Usbiological | 259979 | 4-Amino-3-hydroxybenzoic acid Asreported | 2374-03-0 | 2g | $292 | 2026-06-03 | Buy |
4-Amino-3-hydroxybenzoic acid Chemical Properties,Uses,Production
Chemical Properties
yellow-brown to brown crystalline powder
Uses
4-Amino-3-hydroxybenzoic acid is used in the preparation of various pharmaceutical compounds such as sphingosine kinase inhibitors.
Uses
4-Amino-3-hydroxybenzoic Acid is disubsituted benzoic acid used in the preparation of various pharmaceutical compounds such as sphingosine kinase inhibitors.
reaction suitability
reaction type: solution phase peptide synthesis
Synthesis
Step 1: Preparation of 3-hydroxy-4-nitrobenzoic acid (Compound 4A)
3-Hydroxybenzoic acid (220 mg, 1.6 mmol) was dissolved in acetonitrile, and after complete dissolution, ceric ammonium nitrate (1.26 g, 2.3 mmol) was added slowly in batches and stirred at room temperature overnight. The reaction was quenched with water at the end of the reaction, extracted with ethyl acetate, the organic terms were combined, dried, concentrated under reduced pressure and then chromatographed on a column (eluting with ethyl acetate) to obtain the solid product Compound 4A (85 mg, 27% yield).
Step 2, the preparation of 4-amino-3-hydroxybenzoic acid (compound 4B)
Compound 4A (85 mg, 0.8 mmol) was dissolved in methanol, Pd/C catalyst was added and then reacted at room temperature under the protection of hydrogen overnight, at the end of the reaction, the insoluble solid was filtered to remove the solid, and the organic layer was concentrated under reduced pressure to obtain the solid was not purified and used directly for the next step of the reaction.
4-Amino-3-hydroxybenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Xi'an Yutbon Pharmaceutical Technology Co., Ltd | 029-81140587 +8618717328141 | sales@yutbon.com | China | 454 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 +8613131129325 | sales1@chuanghaibio.com | China | 5228 | 58 |
| Changzhou Rokechem Technology Co., Ltd. | 18758118018 | sales001@rokechem.com | China | 255 | 58 |
| Cangzhou Kangrui Pharma Tech Co. Ltd., | +86-18632776803 +86-13833998158 | cangzhoukangrui@126.com | China | 773 | 58 |
| Hebei Zhuanglai Chemical Trading Co Ltd | +86-16264648883 | niki@zlchemi.com | China | 7245 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21586 | 55 |
| Fluoropharm Co., Ltd. | +86-0571-85586753 +86-13336034509 | sales@fluoropharm.com | China | 1445 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Speranza Chemical Co., Ltd. | +86-86-075521030354 +8618688942810 | sophieliu@speranzachem.com | China | 923 | 55 |
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View Lastest Price from 4-Amino-3-hydroxybenzoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-22 | 4-Amino-3-Hydroxy Benzoic Acid
2374-03-0
|
$20.00 | 1KG | 98% & 99% | 100MT/year | Speranza Chemical Co., Ltd. | |
 |
2026-06-15 | 4-Amino-3-hydroxybenzoic acid
2374-03-0
|
1KG | ≥99% | 100KG | Jinan Finer Chemical Co., Ltd | ||
 |
2026-06-08 | 4-amino-3-Hydroxy benzoic acid
2374-03-0
|
1kg | 99% | 1 | Jinan Ruitong Biotech Co., Ltd. |
-
- 4-Amino-3-Hydroxy Benzoic Acid
2374-03-0
- $20.00
- 98% & 99%
- Speranza Chemical Co., Ltd.
-
- 4-Amino-3-hydroxybenzoic acid
2374-03-0
- $0.00
- ≥99%
- Jinan Finer Chemical Co., Ltd
-
- 4-amino-3-Hydroxy benzoic acid
2374-03-0
- 99%
- Jinan Ruitong Biotech Co., Ltd.
