(2S,5S)-N-Boc-5-methylpyrrolidine-2-carboxylic acid
- CAS No.
- 334769-80-1
- Chemical Name:
- (2S,5S)-N-Boc-5-methylpyrrolidine-2-carboxylic acid
- Synonyms
- (2S,5S)-1-(tert-Butoxycarbonyl)-5-methylpyrrolidine-2-carboxylic acid;EOS-60522;GS-5817 interMediate;Boc-cis-5-methyl-Pro-OH;(2S,5S)-Boc-5-methylpyrrolidine-2-carboxylic acid;(2S,5S)-N-Boc-5-Methylpyrrolidine-2-carboxylic aci;(2s,5s)-n-boc-5-methylpyrrolidine-2-carboxylic acid;(2S,5S)-1-Boc-5-methylpyrrolidine-2-carboxylic Acid;cis-5-Methyl-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester;(2S,5S)-5-methyl-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester
- CBNumber:
- CB21267594
- Molecular Formula:
- C11H19NO4
- Molecular Weight:
- 229.27
- MDL Number:
- MFCD13185989
- MOL File:
- 334769-80-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| (2S,5S)-Boc-5-methylpyrrolidine-2-carboxylic acid | 231167 | 250mg | $360 |
| (2S,5S)-Boc-5-methylpyrrolidine-2-carboxylic acid | 231167 | 1g | $948 |
| (2S,5S)-Boc-5-methylpyrrolidine-2-carboxylic acid | 231167 | 5g | $3405 |
| (2S,5S)-Boc-5-methylpyrrolidine-2-carboxylic acid ≥99%(ChiralHPLC,HPLC) | 29775 | 250MG | $194.99 |
| Boc-L-Pro(5-Me)-OH (2S,5S) | BAA3440 | 250mg | $396 |
| More product size | |||
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
(2S,5S)-N-Boc-5-methylpyrrolidine-2-carboxylic acid price More Price(49)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 231167 | (2S,5S)-Boc-5-methylpyrrolidine-2-carboxylic acid | 334769-80-1 | 250mg | $360 | 2026-06-03 | Buy |
| Usbiological | 231167 | (2S,5S)-Boc-5-methylpyrrolidine-2-carboxylic acid | 334769-80-1 | 1g | $948 | 2026-06-03 | Buy |
| Usbiological | 231167 | (2S,5S)-Boc-5-methylpyrrolidine-2-carboxylic acid | 334769-80-1 | 5g | $3405 | 2026-06-03 | Buy |
| Chem-Impex | 29775 | (2S,5S)-Boc-5-methylpyrrolidine-2-carboxylic acid ≥99%(ChiralHPLC,HPLC) | 334769-80-1 | 250MG | $194.99 | 2026-05-19 | Buy |
| Iris Biotech GmbH | BAA3440 | Boc-L-Pro(5-Me)-OH (2S,5S) | 334769-80-1 | 250mg | $396 | 2026-05-19 | Buy |
(2S,5S)-N-Boc-5-methylpyrrolidine-2-carboxylic acid Chemical Properties,Uses,Production
Synthesis
676560-83-1
334769-80-1
The general procedure for the synthesis of (2S,5S)-N-Boc-5-methylpyrrolidine-2-carboxylic acid from the compound (CAS: 676560-83-1) is as follows: 1. ethyl (2S,5S)-1-(tert-butoxycarbonyl)-5-methylpyrrolidine-2-carboxylate (6.46 g, 25.1 mmol) was dissolved in ethanol (20 mL). 2. Lithium hydroxide monohydrate (2.11 g, 50.2 mmol) and deionized water (12 mL) were added to the above solution. 3. The reaction mixture was stirred at room temperature for 16 hours. 4. 4. Upon completion of the reaction, the mixture was partitioned between ethyl acetate and a 1:1 mixture of saturated aqueous sodium chloride solution and 1N hydrochloric acid. 5. The aqueous layer was separated and extracted again with ethyl acetate. 6. Combine all organic layers and dry with anhydrous sodium sulfate. 7. Vacuum removal of the solvent afforded (2S,5S)-1-(tert-butoxycarbonyl)-5-methylpyrrolidine-2-carboxylic acid as a white solid (quantitative yield), which was used directly in the next reaction without further purification.
References
[1] Patent: US2014/178336, 2014, A1. Location in patent: Paragraph 0252
[2] Patent: US2015/361087, 2015, A1. Location in patent: Paragraph 0311; 0316
[3] Patent: WO2015/110048, 2015, A1. Location in patent: Paragraph 00165
[4] Patent: US2017/44140, 2017, A1. Location in patent: Paragraph 0218; 0231; 0232; 0233
[5] Journal of Medicinal Chemistry, 2006, vol. 49, # 12, p. 3520 - 3535
(2S,5S)-N-Boc-5-methylpyrrolidine-2-carboxylic acid Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 13901 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Shanghai Yingrui Biopharma Co.,Ltd | 21-33585366 | export01@shyrchem.com | CHINA | 1319 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | sales@afinechem.com | China | 15083 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
View Lastest Price from (2S,5S)-N-Boc-5-methylpyrrolidine-2-carboxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2019-07-06 | (2S,5S)-N-Boc-5-methylpyrrolidine-2-carboxylic acid
334769-80-1
|
$100.00 | 1KG | 98% | 100KG | Career Henan Chemical Co |
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- (2S,5S)-N-Boc-5-methylpyrrolidine-2-carboxylic acid
334769-80-1
- $100.00
- 98%
- Career Henan Chemical Co
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