3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE
- CAS No.
- 72537-17-8
- Chemical Name:
- 3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE
- Synonyms
- 2-FLUORO-3-CHLORO-5-(TRIFLUOROMETHYL)PYRIDINE;CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE;3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE;Pyridine, 3-chloro-2-fluoro-5-(trifluoromethyl)-;3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine >3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine 98%;TIANFU-CHEM 3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE;3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE ISO 9001：2015 REACH
- CBNumber:
- CB2145237
- Molecular Formula:
- C6H2ClF4N
- Molecular Weight:
- 199.53
- MDL Number:
- MFCD00191918
- MOL File:
- 72537-17-8.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine 98% | 393576 | 5g | $105 |
| 3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine >98.0%(GC) | C2671 | 5g | $58 |
| 3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine >98% | PC4375 | 5g | $21 |
| 3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine >98% | PC4375 | 25g | $37 |
| 3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine >98% | PC4375 | 100g | $138 |
| More product size | |||
| Melting point | 16-20 °C (lit.) |
|---|---|
| Boiling point | 50-55 °C/11 mmHg (lit.) |
| Density | 1.524 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | 125 °F |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | Liquid |
| color | Colorless |
| InChI | InChI=1S/C6H2ClF4N/c7-4-1-3(6(9,10)11)2-12-5(4)8/h1-2H |
| InChIKey | GDSROTVTTLUHCO-UHFFFAOYSA-N |
| SMILES | C1(F)=NC=C(C(F)(F)F)C=C1Cl |
| CAS DataBase Reference | 72537-17-8(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H226-H315-H319-H335 | |||||||||
| Precautionary statements | P210-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 10-36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| RIDADR | UN 1993 3/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HazardClass | 3.2 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29333990 | |||||||||
| Storage Class | 3 - Flammable liquids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Flam. Liq. 3 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE price More Price(62)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 393576 | 3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine 98% | 72537-17-8 | 5g | $105 | 2023-01-07 | Buy |
| TCI Chemical | C2671 | 3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine >98.0%(GC) | 72537-17-8 | 5g | $58 | 2026-04-30 | Buy |
| Apolloscientific | PC4375 | 3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine >98% | 72537-17-8 | 5g | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC4375 | 3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine >98% | 72537-17-8 | 25g | $37 | 2026-06-04 | Buy |
| Apolloscientific | PC4375 | 3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine >98% | 72537-17-8 | 100g | $138 | 2026-06-04 | Buy |
3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE Chemical Properties,Uses,Production
Uses
3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine, a halogenated pyridine derivative, is a fluorinated building block. It participates in the synthesis of 2,3-difluoro-5-(trifluoromethyl)pyridine.
General Description
3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine, a halogenated pyridine derivative, is a fluorinated building block. It participates in the synthesis of 2,3-difluoro-5-(trifluoromethyl)pyridine.
Synthesis
69045-84-7
72537-17-8
The general procedure for the synthesis of 3-chloro-2-fluoro-5-(trifluoromethyl)pyridine from 2,3-dichloro-5-trifluoromethylpyridine is as follows: Example 3b. Equipment: 250 mL four-necked round-bottomed flask equipped with a thermometer, mechanical stirrer, dropping funnel and inert gas inlet. Operating steps: 1. 25 mL of DMSO was added to a 250 mL four-necked round-bottomed flask, and the solvent was evaporated from a suspension of 150 mL of DMSO, 2.5 g of potassium carbonate (17.9 mmol), and 25.0 g of cesium fluoride (162.9 mmol) at 120 °C and 25-30 mbar pressure. 2. 25.0 g of 2,3-dichloro-5-trifluoromethylpyridine (112.3 mmol) was added to the reaction mixture and the reaction was stirred at 120 °C for 4 hours. 3. After completion of the reaction, the suspension was filtered and the product 3-chloro-2-fluoro-5-(trifluoromethyl)pyridine was distilled directly from the distillate at 95 to 115 °C and 40-60 mbar pressure to obtain the product in quantitative yield. PRODUCT ANALYSIS: GC analysis showed a product purity of 96.9 area percent.
References
[1] Patent: US2008/221327, 2008, A1. Location in patent: Page/Page column 9-10
[2] Patent: US2008/221327, 2008, A1. Location in patent: Page/Page column 6
[3] Patent: CN107286087, 2017, A. Location in patent: Paragraph 0032; 0033
[4] Patent: CN106905231, 2017, A. Location in patent: Paragraph 0077; 0078; 0079; 0080; 0081; 0082; 0083-0085
[5] Patent: EP1199305, 2002, A1. Location in patent: Page 6
3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shandong Jihui Chemical Co., Ltd. | +8615053042019 | sales@jihuichem.com | China | 34 | 58 |
| Nantong Guangyuan Chemicl Co,Ltd | +undefined17712220823 | admin@guyunchem.com | China | 615 | 58 |
| Dongfan Chem. Co., Ltd. | 021-34500607 13391355195 | sales@dfanchem.com | CHINA | 61 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21587 | 55 |
| Fluoropharm Co., Ltd. | +86-0571-85586753 +86-13336034509 | sales@fluoropharm.com | China | 1445 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
View Lastest Price from 3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-02-28 | 2-Fluoro-3-chloro-5-(trifluoromethyl)pyridine
72537-17-8
|
250KG | Purity: 99% | 1000tons | Shandong Jihui Chemical Co., Ltd. | ||
 |
2025-11-18 | 3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE
72537-17-8
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2019-07-06 | 3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE
72537-17-8
|
$1.00 | 1KG | 98% | 1kg,5kg,100kg | Career Henan Chemical Co |
-
- 2-Fluoro-3-chloro-5-(trifluoromethyl)pyridine
72537-17-8
- Purity: 99%
- Shandong Jihui Chemical Co., Ltd.
-
- 3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE
72537-17-8
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE
72537-17-8
- $1.00
- 98%
- Career Henan Chemical Co
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