(3-chloropyrazin-2-yl)methanol
- CAS No.
- 89283-32-9
- Chemical Name:
- (3-chloropyrazin-2-yl)methanol
- Synonyms
- 3-Chloro-2-pyrazinemethanol;3-Chloro-2-pyrazineMethan...;2-PyrazineMethanol, 3-chloro-;(3-chloro-2-pyrazinyl)methanol;(3-chloropyrazin-2-yl)methanol;3-Chloro-2-(hydroxymethyl)pyrazine
- CBNumber:
- CB22123934
- Molecular Formula:
- C5H5ClN2O
- Molecular Weight:
- 144.56
- MDL Number:
- MFCD11977628
- MOL File:
- 89283-32-9.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| (3-Chloropyrazin-2-yl)methanol 98% | OR321372 | 250mg | $25 |
| (3-Chloropyrazin-2-yl)methanol 98% | OR321372 | 1g | $30 |
| (3-Chloropyrazin-2-yl)methanol 98% | OR321372 | 5g | $93 |
| 3-Chloro-2-pyrazinemethanol 97% | AS12851 | 1g | $39 |
| 3-Chloro-2-pyrazinemethanol 97% | AS12851 | 5g | $144 |
| More product size | |||
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H319-H335-H302+H312+H332-H315 |
| Precautionary statements | P280-P301+P312-P302+P352 |
| HS Code | 2933998090 |
(3-chloropyrazin-2-yl)methanol price More Price(42)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR321372 | (3-Chloropyrazin-2-yl)methanol 98% | 89283-32-9 | 250mg | $25 | 2026-06-04 | Buy |
| Apolloscientific | OR321372 | (3-Chloropyrazin-2-yl)methanol 98% | 89283-32-9 | 1g | $30 | 2026-06-04 | Buy |
| Apolloscientific | OR321372 | (3-Chloropyrazin-2-yl)methanol 98% | 89283-32-9 | 5g | $93 | 2026-06-04 | Buy |
| Activate Scientific | AS12851 | 3-Chloro-2-pyrazinemethanol 97% | 89283-32-9 | 1g | $39 | 2026-06-04 | Buy |
| Activate Scientific | AS12851 | 3-Chloro-2-pyrazinemethanol 97% | 89283-32-9 | 5g | $144 | 2026-06-04 | Buy |
(3-chloropyrazin-2-yl)methanol Chemical Properties,Uses,Production
Uses
(3-Chloropyrazin-2-yl)methanol (cas# 89283-32-9) is a useful reagent for the preparation of indazolylquinazolinones as inhibitors of human immunodeficiency virus replication.
Synthesis
27398-39-6
89283-32-9
General procedure for the synthesis of 3-chloropyrazine-2-methanol from 2-chloropyrazine-3-carboxylic acid: 3-chloropyrazine-2-carboxylic acid (2.97 g, 18.73 mmol, 1 equiv) was dissolved in tetrahydrofuran (75 mL). The solution was stirred under ice bath conditions and the latter was added dropwise by adding triethylamine (5.2 mL, 37.5 mmol, 2 equiv.) and methyl chloroformate (1.74 mL, 22.5 mmol, 1.2 equiv.) sequentially. After 30 min of reaction, the reaction mixture was filtered and the solid was washed with additional tetrahydrofuran (10 mL). The resulting tetrahydrofuran solution was placed in an ice bath with stirring and a suspension of sodium borohydride (1.4 g, 37.5 mmol, 2 equiv) in water (3 mL) was slowly added. After 1 hour of reaction, saturated aqueous ammonium chloride solution (100 mL) was added to the reaction mixture, followed by extraction with ethyl acetate (2 x 100 mL). The organic phases were combined, washed with saturated aqueous sodium chloride solution (25 mL) and dried over anhydrous sodium sulfate. After filtration, the solvent was evaporated and the residue was purified by silica gel column chromatography (eluent: 5-70% ethyl acetate/hexane) to afford the target product (3-chloropyrazin-2-yl)methanol (0.84 g, 31% yield) as a light-colored oil.
References
[1] Patent: WO2016/160755, 2016, A1. Location in patent: Page/Page column 30
[2] Patent: WO2013/102145, 2013, A1. Location in patent: Paragraph 0290
(3-chloropyrazin-2-yl)methanol Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Wuxi Rejoys chemical Technology Co., Ltd. | 0510-86103381 | sales@rejoyschem.com | CHINA | 976 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25356 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43333 | 58 |
View Lastest Price from (3-chloropyrazin-2-yl)methanol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-08-29 | (3-chloropyrazin-2-yl)methanol
89283-32-9
|
$1.00-2.00 | 1KG | 95%-99% | 100kg | Career Henan Chemical Co |
-
- (3-chloropyrazin-2-yl)methanol
89283-32-9
- $1.00-2.00
- 95%-99%
- Career Henan Chemical Co
