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ChemicalBook >> CAS DataBase List >>lurasidone

lurasidone

CAS No.
367514-87-2
Chemical Name:
lurasidone
Synonyms
CS-327;urasidone;lurasidone;Luclazepam;Lurasindone;D8-Lurasidone;Lurasidone Base;Lurasidone, >=98%;Lurasidone (SM13496);lurasidone USP/EP/BP
CBNumber:
CB22498821
Molecular Formula:
C28H36N4O2S
Molecular Weight:
492.68
MDL Number:
MFCD14635357
MOL File:
367514-87-2.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 00:01:33
Product description Number Pack Size Price
Lurasidone L0280 250MG $64
Lurasidone ≥98% 9000570 1mg $63
Lurasidone ≥98% 9000570 5mg $213
Lurasidone ≥98% 9000570 10mg $303
Lurasidone ≥98% 9000570 25mg $454
More product size

lurasidone Properties

Melting point 146-149°C
Boiling point 623.4±55.0 °C(Predicted)
Density 1.273
storage temp. -20°C Freezer
solubility Chloroform (Slightly), DMSO (Slightly, Heated), Methanol (Slightly, Heated)
pka 8.41±0.50(Predicted)
form Solid
color White to Off-White
InChIKey PQXKDMSYBGKCJA-CVTJIBDQSA-N
SMILES C1(=O)[C@]2([H])[C@@]([H])([C@]3([H])C[C@@]2([H])CC3)C(=O)N1C[C@@H]1CCCC[C@H]1CN1CCN(C2C3=C(SN=2)C=CC=C3)CC1
CAS DataBase Reference 367514-87-2
FDA UNII 22IC88528T
ATC code N05AE05

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338
Hazardous Substances Data 367514-87-2(Hazardous Substances Data)
REACH Registrations Active
NFPA 704
0
3 0

lurasidone price More Price(72)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical L0280 Lurasidone 367514-87-2 250MG $64 2026-04-30 Buy
Cayman Chemical 9000570 Lurasidone ≥98% 367514-87-2 1mg $63 2026-04-30 Buy
Cayman Chemical 9000570 Lurasidone ≥98% 367514-87-2 5mg $213 2026-04-30 Buy
Cayman Chemical 9000570 Lurasidone ≥98% 367514-87-2 10mg $303 2026-04-30 Buy
Cayman Chemical 9000570 Lurasidone ≥98% 367514-87-2 25mg $454 2026-04-30 Buy
Product number Packaging Price Buy
L0280 250MG $64 Buy
9000570 1mg $63 Buy
9000570 5mg $213 Buy
9000570 10mg $303 Buy
9000570 25mg $454 Buy

lurasidone Chemical Properties,Uses,Production

Drug for the treatment of schizophrenia

Lurasidone is developed by Japan's Dainippon Sumitomo Pharma which is an atypical antipsychotic,and is a classification of drug registration 3.1 class, it is suitable for the treatment of patients with schizophrenia. Its efficacy is Determined in four six weeks in adult patients with schizophrenia controlled studies. The exact mechanism of the treatment of schizophrenia, like other atypical antipsychotics ,is not very clear,and may be related to the antagonism of the dopamine D2 and serotonin 2A (5-HT2A) receptors. For the treatment of schizophrenia, a study has reported lurasidone can improve cognitive function.
October 28, 2010 ,the FDA approved lurasidone hydrochloride (lurasidone HCI) tablets once a day for the first-line treatment of patients with schizophrenia, the trade name is Latuda.
Dosage: The recommended starting dose is 40 mg/d, the effective dose range is 40~120 mg /· d, the maximum recommended dose is 80 mg /· d. It should be taken with food.
Adverse reaction: common adverse reactions are somnolence, akathisia, nausea, Parkinson's disease-like symptoms and emotional anxiety. Lurasidone has no physical dependence, less likely to cause weight gain, it does not cause glucose, lipids (lipids), it changs the period between ECG and QT.
The above information is edited by the Chemicalbook of Tian Ye.

Description

The atypical antipsychotic lurasidone (also known as SM-13496) was approved in the United States in 2010 as an oral agent for the treatment of patients with schizophrenia. Lurasidone has potent affinity for D2 (Ki= 1.7 nM) and 5-HT2A (Ki= 2.0 nM) receptors and acts as an antagonist at both receptors. It is also a partial agonist at the 5-HT1A receptor and, unlike other atypical agents, is a potent antagonist at the 5-HT7 receptor; both of these activities are thought to confer beneficial cognitive properties. Lurasidone is further differentiated by its lack of affinity for muscarinic and histamine H1 receptors and its weak affinity for the 5-HT2C receptor. Antagonism at H1 and 5-HT2C receptors has been implicated in weight gain associated with atypical agents, while muscarinic receptor antagonism is associated with cognitive deficits.

Originator

Dainippon Sumitomo Pharma (Japan)

Definition

ChEBI: An N-arylpiperazine that is (3aR,4S,7R,7aS)-2-{[(1R,2R)-2-(piperazin-1-ylmethyl)cyclohexyl]methyl}hexahydro-1H-4,7-m thanoisoindole-1,3(2H)-dione in which position N4 of the piperazine ring is substituted by a 1,2-benzothiazol-3-yl group. Lurasidone is used (generally as the hydrochloride salt) as an atypical antipsychotic for the treatment of schizoph enia.

brand name

Latuda

lurasidone Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 241)Suppliers
Supplier Tel Email Country ProdList Advantage
Jinan Million Pharmaceutical Co., Ltd
0531-68659554 +8613031714605 info@millionpharm.com China 184 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29640 60
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1803 55
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21586 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
Lianyungang happen teng technology co., LTD 		15950718863 wang666xt@163.com CHINA 295 58
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29812 58
Jinan Jianfeng Chemical Co., Ltd 		+86-0531-88110457 +8615562555968 info@pharmachemm.com China 311 58
Shochem(Shanghai) Co.,Ltd 		86-21-50800795 info@shochem.com CHINA 288 58
TopScience Biochemical 		00852-68527855 info@itopbiochem.com China Hong Kong 902 58

View Lastest Price from lurasidone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
lurasidone pictures 2026-06-22 lurasidone
367514-87-2
 $2.00 1kg 99% 200KG/M Jinan Million Pharmaceutical Co., Ltd
Lurasidone pictures 2026-06-16 Lurasidone
367514-87-2
 0.99 RongNa Biotechnology Co.,Ltd
Lurasidone pictures 2026-05-11 Lurasidone
367514-87-2
 $39.00-78.00 99.78% 10g TargetMol Chemicals Inc.
  • lurasidone pictures
  • lurasidone
    367514-87-2
  • $2.00
  • 99%
  • Jinan Million Pharmaceutical Co., Ltd
  • Lurasidone pictures
  • Lurasidone
    367514-87-2
  • 0.99
  • RongNa Biotechnology Co.,Ltd
  • Lurasidone pictures
  • Lurasidone
    367514-87-2
  • $39.00-78.00
  • 99.78%
  • TargetMol Chemicals Inc.

lurasidone Spectrum

4-{[(1R,2R)-2-{[4-(2$l^{4}-thia-6-azatricyclo[5.4.0.0^{2,6}]undeca-1(11),2,4,7,9-pentaen-5-yl)piperazin-1-yl]Methyl}cyclohexyl]Methyl}-4-azatricyclo[5.2.1.0^{2,6}]deca-1(9),2(6),7-triene-3,5-dione lurasidone (3aR,4S,7R,7aS)-2-[[(1R,2R)-2-[[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]methyl]cyclohexyl]methyl]hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione Lurasidone (SM13496) (3aR,4S,7R,7aS)-2-{[(1R,2R)-2-{[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]Methyl}cyclohexyl]Methyl}hexahydro-1H-4,7-Methanoisoindole-1,3(2H)-dione urasidone Lurasidone, >=98% Lurasidone Base (3aR,4S,7R,7aS)-2-((1R,2R)-2-(4-(1,2-Benzothiazol-3-yl)piperazin-1-ylmethyl)cyclohexylmethyl)hexahydro-4,7-methano-2H-isoindole-1,3-dione CS-327 4,7-Methano-1H-isoindole-1,3(2H)-dione, 2-[[(1R,2R)-2-[[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]methyl]cyclohexyl]methyl]hexahydro-, (3aR,4S,7R,7aS)- (3aR,4S,7R,7aS)-2-[[(1R,2R)-2-[[4-(Benzo[d]isothiazol-3-yl)piperazin-1-yl]methyl]cyclohexyl]methyl]hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione lurasidone USP/EP/BP TIANFU-CHEM - lurasidone SM13496; SM-13496; SM 13496 Lurasidone Free base Lurasindone (3aR,4S,7R,7aS)-2-[[(1R,2R)-2-[[4-(1,2-Benzisothiazol-3-yl)-1-piperazinylChemicalbook]methyl]cyclohexyl]methyl]hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione (3aR,4S,7R,7aS)-2-{[(1R,2R)-2-{[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]Methyl}cyclohexyl]Methyl}hexahydro-1H-4 Lurasidone (3aR,4S,7R,7aS)-2-(((1R,2R)-2-((4-(benzo[d]isothiazol-3- yl)piperazin-1-yl)methyl) cyclohexyl)methyl)hexahydro-1H-4,7-methanoisoindole-1,3(2H)- dione (1R,2S,6R,7S)-4-{[(1R,2R)-2-{[4-(1,2-benzothiazol-3- yl)piperazin-1-yl]methyl}-cyclohexyl]methyl}-4- azatricyclo[5.2.1.0^{2,6}]decane-3,5-dione Luclazepam D8-Lurasidone Lurasidone (Standard) 367514-87-2 C28H36N4O2S Pharmaceutical intermediate
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