METHYL 2-(S)-[N-CARBOBENZYLOXY]AMINO-3-AMINOPROPIONATE, HYDROCHLORIDE
![METHYL 2-(S)-[N-CARBOBENZYLOXY]AMINO-3-AMINOPROPIONATE, HYDROCHLORIDE Structure](CAS/GIF/35761-27-4.gif)
- CAS No.
- 35761-27-4
- Chemical Name:
- METHYL 2-(S)-[N-CARBOBENZYLOXY]AMINO-3-AMINOPROPIONATE, HYDROCHLORIDE
- Synonyms
- Z-Dap-OMe.HCl;Z-L-Dap-OMe*HCl;CBZ-Dap-OMe.HCl;3-Amino-N-Cbz-L-alanine methyl ester HCl;Methyl 2-(S)-[N-Carbobenzyloxy]amino-3-aminopropionate;benzyl (S)-1-(methoxycarbonyl)-2-aminoethylcarbamate HCl;Methyl (S)-3-Amino-2-(Cbz-amino)propanoate Hydrochloride;3-Amino-N-[(phenylmethoxy)carbonyl]-L-alanine methyl ester;Methyl 2-(s)-[n-carbobenzyloxy]amino-3-aminopropionate, HCl;3-Amino-N-(benzyloxycarbonyl)-L-alanine methyl ester hydrochloride
- CBNumber:
- CB2251802
- Molecular Formula:
- C12H17ClN2O4
- Molecular Weight:
- 288.73
- MDL Number:
- MFCD03701202
- MOL File:
- 35761-27-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Methyl 2-(S)-[N-Carbobenzyloxy]amino-3-aminopropionate, Hydrochloride (Methyl 2-(S)-[N-[(Benzyloxy)carbonyl]amino-3-aminopropionate, Hydrochloride) | M3395 | 500mg | $446 |
| Na-Z-L-2,3-diaminopropionic acid methyl ester hydrochloride 98+% (HPLC) ≥98%(HPLC) | 240718 | 250mg | $233 |
| Na-Z-L-2,3-diaminopropionic acid methyl ester hydrochloride 98+% (HPLC) ≥98%(HPLC) | 240718 | 1g | $326 |
| Na-Z-L-2,3-diaminopropionic acid methyl ester hydrochloride 98+% (HPLC) ≥98%(HPLC) | 240718 | 5g | $849 |
| Methyl 2-(S)-[N-Carbobenzyloxy]amino-3-aminopropionate, Hydrochloride | TRC-M294430-500MG | 500mg | $109 |
| More product size | |||
| Melting point | 157-162°C dec. |
|---|---|
| storage temp. | Inert atmosphere,2-8°C |
| solubility | Chloroform, Methanol |
| form | Solid |
| color | White |
| optical activity | Consistent with structure |
| FDA UNII | 2NKW3MQF65 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P280-P305+P351+P338 |
| HS Code | 2924297099 |
METHYL 2-(S)-[N-CARBOBENZYLOXY]AMINO-3-AMINOPROPIONATE, HYDROCHLORIDE price More Price(72)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | M3395 | Methyl 2-(S)-[N-Carbobenzyloxy]amino-3-aminopropionate, Hydrochloride (Methyl 2-(S)-[N-[(Benzyloxy)carbonyl]amino-3-aminopropionate, Hydrochloride) | 35761-27-4 | 500mg | $446 | 2026-06-03 | Buy |
| Usbiological | 240718 | Na-Z-L-2,3-diaminopropionic acid methyl ester hydrochloride 98+% (HPLC) ≥98%(HPLC) | 35761-27-4 | 250mg | $233 | 2026-06-03 | Buy |
| Usbiological | 240718 | Na-Z-L-2,3-diaminopropionic acid methyl ester hydrochloride 98+% (HPLC) ≥98%(HPLC) | 35761-27-4 | 1g | $326 | 2026-06-03 | Buy |
| Usbiological | 240718 | Na-Z-L-2,3-diaminopropionic acid methyl ester hydrochloride 98+% (HPLC) ≥98%(HPLC) | 35761-27-4 | 5g | $849 | 2026-06-03 | Buy |
| TRC | TRC-M294430-500MG | Methyl 2-(S)-[N-Carbobenzyloxy]amino-3-aminopropionate, Hydrochloride | 35761-27-4 | 500mg | $109 | 2026-06-03 | Buy |
METHYL 2-(S)-[N-CARBOBENZYLOXY]AMINO-3-AMINOPROPIONATE, HYDROCHLORIDE Chemical Properties,Uses,Production
Chemical Properties
White Solid
Uses
Important building block for the synthesis of peptides containing DAP residues, e.g. bleomycins, edeines, tuberactinomycins.
Synthesis
![3-Amino-N-[(Phenylmethoxy)Carbonyl]-Alanine Methyl Ester](/CAS/20200401/GIF/75760-11-1.gif)
75760-11-1
![METHYL 2-(S)-[N-CARBOBENZYLOXY]AMINO-3-AMINOPROPIONATE, HYDROCHLORIDE](/CAS/GIF/35761-27-4.gif)
35761-27-4
General procedure for the synthesis of methyl (S)-3-amino-2-(((benzyloxy)carbonyl)amino)propanoate hydrochloride from compound (CAS: 75760-11-1): 3-amino-N-[(benzyloxy)carbonyl]-L-alanine methyl ester (5.0 g, 21.0 mmol) and anhydrous methanol (100 mL) were added to a flask fitted with a magnetic stir bar. HCl gas was passed into the solution/slurry for about 10 minutes under stirring conditions. After about 2 minutes, an exothermic reaction was observed and the solution changed from turbid white to clear/colorless. After stirring the reaction solution overnight, it was concentrated and dried by vacuum to afford methyl (S)-3-amino-2-(((benzyloxy)carbonyl)amino)propionate hydrochloride (6.0 g, 98% yield) as white crystals.1H NMR (δ): 3.05 (t, 1H), 3.19 (t, 1H), 3.70 (s, 3H), 4.45 (m, 1H), 5.10 ( s, 2H), 7.38 (m, 5H), 7.95 (d, 1H), 8.35 (br s, 3H).LCMS (ES, M + H = 253).
References
[1] Patent: WO2006/106326, 2006, A1. Location in patent: Page/Page column 99
METHYL 2-(S)-[N-CARBOBENZYLOXY]AMINO-3-AMINOPROPIONATE, HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
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| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43333 | 58 |
| DAYANG CHEM (HANGZHOU) CO.,LTD | +86-88938639 +86-17705817739 | info@dycnchem.com | China | 53803 | 58 |
| DONBOO AMINO ACID COMPANY | +8618051385538 | donboo@donboo.com | China | 9363 | 58 |
