5-Chloro-2-nitrotoluene
- CAS No.
- 5367-28-2
- Chemical Name:
- 5-Chloro-2-nitrotoluene
- Synonyms
- 5-Chloro-2-nit;3-chloro-6-nitrotoluene;5-CHLORO-2-NITROTOLUENE;5-chloro-2-nitro-toluen;2-Nitro-5-chlorotoluene;Toluene, 5-chloro-2-nitro-;5-Chloro-2-nitrotoluene,98%;5-Chloro-2-nitrotoluene >3-Methyl-4-nitrochlorobenzene;1-Chloro-3-methyl-4-nitrobenzene
- CBNumber:
- CB2265005
- Molecular Formula:
- C7H6ClNO2
- Molecular Weight:
- 171.58
- MDL Number:
- MFCD00024579
- MOL File:
- 5367-28-2.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 5-Chloro-2-nitrotoluene 98% | 226653 | 25g | $45.6 |
| 5-Chloro-2-nitrotoluene >97.0%(GC) | C2586 | 5g | $25 |
| 5-Chloro-2-nitrotoluene >97.0%(GC) | C2586 | 25g | $76 |
| 5-CHLORO-2-NITROTOLUENE 97% | 23024 | 5G | $40 |
| 5-Chloro-2-nitrotoluene | FC70700 | 100g | $150 |
| More product size | |||
| Melting point | 27-30 °C (lit.) |
|---|---|
| Boiling point | 124-126 °C (16 mmHg) |
| Density | 1.32 |
| refractive index | 1.57-1.572 |
| Flash point | 202 °F |
| storage temp. | Inert atmosphere,Room Temperature |
| form | powder to lump |
| color | White to Light yellow |
| Water Solubility | insoluble |
| InChI | 1S/C7H6ClNO2/c1-5-4-6(8)2-3-7(5)9(10)11/h2-4H,1H3 |
| InChIKey | NSMZCUAVEOTJDS-UHFFFAOYSA-N |
| SMILES | Cc1cc(Cl)ccc1[N+]([O-])=O |
| CAS DataBase Reference | 5367-28-2(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| NIST Chemistry Reference | 5-Chloro-2-nitrotoluene(5367-28-2) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H319 | |||||||||
| Precautionary statements | P264-P270-P280-P301+P312-P305+P351+P338-P337+P313 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xn,N | |||||||||
| Risk Statements | 22-36-36/37/38-20/21/22-52/53 | |||||||||
| Safety Statements | 26-36-36/37/39-61 | |||||||||
| RIDADR | UN 3457 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | XS9134000 | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29049090 | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
|||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 |
|||||||||
| NFPA 704 |
|
5-Chloro-2-nitrotoluene price More Price(57)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 226653 | 5-Chloro-2-nitrotoluene 98% | 5367-28-2 | 25g | $45.6 | 2026-04-30 | Buy |
| TCI Chemical | C2586 | 5-Chloro-2-nitrotoluene >97.0%(GC) | 5367-28-2 | 5g | $25 | 2026-04-30 | Buy |
| TCI Chemical | C2586 | 5-Chloro-2-nitrotoluene >97.0%(GC) | 5367-28-2 | 25g | $76 | 2026-04-30 | Buy |
| AstaTech | 23024 | 5-CHLORO-2-NITROTOLUENE 97% | 5367-28-2 | 5G | $40 | 2026-04-30 | Buy |
| Biosynth | FC70700 | 5-Chloro-2-nitrotoluene | 5367-28-2 | 100g | $150 | 2026-06-04 | Buy |
5-Chloro-2-nitrotoluene Chemical Properties,Uses,Production
Application
5-Chloro-2-nitrotoluene is an organic intermediate that can be obtained by nitrifying o-chlorotoluene.
Chemical Properties
clear yellow liquid
Uses
The cytotoxicity of 5-chloro-2-nitrotoluene, an analog of chlorphenamidine, was studied.
General Description
The cytotoxicity of 5-chloro-2-nitrotoluene, an analog of chlorphenamidine, was studied.
Synthesis
108-41-8
5367-28-2
38939-88-7
General procedure for the synthesis of 5-chloro-2-nitrotoluene and 3-chloro-4-nitrotoluene from 3-chlorotoluene: Concentrated nitric acid (16 mL) was added slowly and dropwise at 0°C to a solution of glacial acetic acid (20 mL) containing 3-chlorotoluene (3 mL, 25.4 mmol) and concentrated sulfuric acid (6 mL). The reaction mixture was stirred at room temperature for 24 hours. Subsequently, the reaction mixture was poured into ice water and liquid-liquid partitioned with ether. After separating the aqueous phase, the aqueous phase was extracted twice with ether. The organic phases were combined, washed sequentially with water and brine, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The yellow oily crude product obtained was purified by silica gel column chromatography and after two rapid chromatographic separations, 1.22 g (14% yield) of 5-chloro-2-nitrotoluene (yellow oily) and 3.39 g (39% yield) of 3-chloro-4-nitrotoluene were obtained.
References
[1] Patent: US2012/15962, 2012, A1. Location in patent: Page/Page column 83
[2] Chemische Berichte, 1900, vol. 33, p. 2505
[3] Bulletin de la Societe Chimique de France, 1900, vol. <3> 23, p. 838
[4] Chemische Berichte, 1900, vol. 33, p. 2505,2506
5-Chloro-2-nitrotoluene Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | 52513593@qq.com | CHINA | 2972 | 58 |
| Shanghai Worldyang Chemical Co.,Ltd. | +86-021-56795779 +8613651600618 | sales@worldyachem.com | China | 967 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569266 +86-17392581500 | 1015@dideu.com | China | 3991 | 58 |
| Richest Group Ltd | 18017061086 | oled@richest-group.com | CHINA | 5600 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-0519-85551759 +8613506123987 | marketing1@neostarunited.com | China | 8828 | 58 |
View Lastest Price from 5-Chloro-2-nitrotoluene manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-03-20 | 5-Chloro-2-nitrotoluene
5367-28-2
|
1KG | 99% | 20 mt | Hebei Chuanghai Biotechnology Co., Ltd | ||
 |
2019-09-04 | 5-Chloro-2-nitrotoluene
5367-28-2
|
$6.00 | 2KG | 98% | 1KG,50KG,100KG | Career Henan Chemical Co |
-
- 5-Chloro-2-nitrotoluene
5367-28-2
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 5-Chloro-2-nitrotoluene
5367-28-2
- $6.00
- 98%
- Career Henan Chemical Co
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