BLASTICIDIN S
- CAS No.
- 2079-00-7
- Chemical Name:
- BLASTICIDIN S
- Synonyms
- blasticidin;bab;Blas;babs;Blaes;bcs-3;toabla-s;cytovirin;bcs-3、bla-s;blastizidin
- CBNumber:
- CB2269508
- Molecular Formula:
- C17H26N8O5
- Molecular Weight:
- 422.44
- MDL Number:
- MFCD02091639
- MOL File:
- 2079-00-7.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Blasticidin S Ready Made Solution, 10 mg/mL (20 mM HEPES) | SBR00022 | 1 mL | $104 |
| Blasticidin S Ready Made Solution, 10 mg/mL (20 mM HEPES) | SBR00022 | 10 mL | $957 |
| Blasticidin S ≥95% | 35252 | 1mg | $51 |
| Blasticidin S ≥95% | 35252 | 5mg | $229 |
| Blasticidin S | CAA07900 | 25mg | $806 |
| More product size | |||
| Melting point | 235°C |
|---|---|
| Boiling point | 539.06°C (rough estimate) |
| alpha | D11 +108.4° (water) |
| Density | 1.1690 (rough estimate) |
| vapor pressure | Low |
| refractive index | 1.6910 (estimate) |
| solubility | DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble; Water: soluble |
| form | A solid |
| pka | 2.4 (carboxyl), 4.6,8.0 and>12.5 (three bases) |
| Water Solubility | >30 g l-1(20 °C) |
| color | colorless to faint yellow |
| Stability | Incompatible with strong oxidizing agents. |
| InChIKey | YQXYQOXRCNEATG-UHFFFAOYSA-N |
| SMILES | CN(CCC(CC(=O)NC1C=CC(OC1C(=O)O)N2C=CC(=NC2=O)N)N)C(=N)N.Cl |
| FDA UNII | 83U64J9U23 |
| EPA Substance Registry System | Blasticidin S (2079-00-7) |
| UNSPSC Code | 12352106 |
| NACRES | NA.76 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300 | |||||||||
| Precautionary statements | P264-P270-P301+P310-P330-P405-P501 | |||||||||
| Hazard Codes | T+ | |||||||||
| Risk Statements | 28 | |||||||||
| Safety Statements | 24/25-36/37-45 | |||||||||
| RIDADR | 3172 | |||||||||
| WGK Germany | WGK 1 | |||||||||
| HazardClass | 6.1(a) | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29349990 | |||||||||
| Storage Class | 6.1D - Non-combustible acute toxic Cat.3 toxic hazardous materials or hazardous materials causing chronic effects |
|||||||||
| Hazard Classifications | Acute Tox. 3 Oral | |||||||||
| Hazardous Substances Data | 2079-00-7(Hazardous Substances Data) | |||||||||
| Toxicity | LD50 i.v. in mice: 2.82 mg/kg (Takeuchi) | |||||||||
| NFPA 704 |
|
BLASTICIDIN S price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SBR00022 | Blasticidin S Ready Made Solution, 10 mg/mL (20 mM HEPES) | 1 mL | $104 | 2026-04-30 | Buy | |
| Sigma-Aldrich | SBR00022 | Blasticidin S Ready Made Solution, 10 mg/mL (20 mM HEPES) | 10 mL | $957 | 2026-04-30 | Buy | |
| Cayman Chemical | 35252 | Blasticidin S ≥95% | 2079-00-7 | 1mg | $51 | 2026-04-30 | Buy |
| Cayman Chemical | 35252 | Blasticidin S ≥95% | 2079-00-7 | 5mg | $229 | 2026-04-30 | Buy |
| Biosynth | CAA07900 | Blasticidin S | 2079-00-7 | 25mg | $806 | 2026-06-04 | Buy |
BLASTICIDIN S Chemical Properties,Uses,Production
Description
Nucleoside antibiotic produced by Streptomyces griseochromogenes (1). Biosynthesized from cytosine, glucose, arginine, and methionine (2).
Chemical Properties
White needle crystal,m.p.253～255℃,[α]D+108.4o, hydrochloride is white crystal, m.p.202～204℃(decomposition). Soluble in acetic acid, insoluble in most organic solvents, solubility in water 12.5%. Chemically stable.
Uses
Blasticidin S is a nucleoside produced by several species of Streptomyces, first reported in the late 1950s. Blasticidin S is an antifungal agent with particularly potent activity against the rice pathogen, Piricularia oryzae, for which it was used commercially for some time in Japan. Blasticidin S inhibits protein synthesis and is active against bacteria, tumour cell lines and nematodes. More recently, blasticidin S has been used as a marker for strain manipulations. Blasticidin S provided by BioAustralis is presented as the free base to avoid problems associated with the use of the hydrochloride.
Uses
Blasticidin-S is used for the control of rice blast (PyricuZuria oryzae) by foliar application.
Production Methods
Blasticidin S is produced by Streptomyces griseochromogenes, and has a wide range of antimicrobial activity (4). This antibiotic was utilized in the Far East beginning in 1961 against the rice blast pathogen Pyricularia oryzae, with effective control achieved at rates of 10–40 ppm (4).
Definition
ChEBI: A blasticidin that is an antibiotic obtained from Streptomyces griseochromogene.
General Description
Blasticidin S was found in the culture broth of Streptomyces griseochromogenes by Yonehara et al. of the University of Tokyo in 1958. It has a nucleoside-analogue structure and shows strong activity against phytopathogenic fungi, especially Pericularia oryzae, the pathogen causing rice blast. Blasticidin S has been used to protect rice plants.
Pharmacology
Inhibits protein synthesis both in eukaryotes and in prokaryotes (5,6). Interacts with ribosomal RNA in large subunit, interfering with the transpeptidation step. Inhibits cell-free protein synthesis in P. oryzae and Escherichia coli.
Metabolic pathway
Several blasticidin S-resistant microorganisms are found to produce blasticidin S deaminase which catalyzes the hydrolytic deamination of the cytosine moiety in blasticidin S to give a non-toxic deaminohydroxy derivative.
Metabolism
3H-blasticidin S administered to mice was excreted in the urine and feces within 24 h. Cytomycin and cytosin were identified as the main metabolites in and on rice plants, respectively (7). In soil, DT50 < 5 d. Metabolized to nontoxic deaminohydroxy blasticidin S by Aspergillus sp. and resistant Bacillus cereus. Novel deaminase and coding genes, BSD and bsr, were isolated as selectable marker genes for genetic engineering (8).
Toxicity evaluation
Acute oral LD50 for male rats: 56.8, female rats: 55.9, male mice: 51.9, and female mice: 60.1 mg/kg. Acute percutaneous LD50 for rats >500 mg/kg. Eye: severe irritation.
Degradation
Blasticidin-S is obtained as white needle crystals which are very soluble in water. The compound is stable in the pH range 5-7 but it is unstable under alkaline conditions. It is readily degraded by sunlight when on the surface of rice plants with the main degradation product being cytosine (2) (Yamaguchi et al., 1972) as shown in Scheme 1.
BLASTICIDIN S Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 9996 | 58 |
| SUZHOU SENFEIDA CHEMICAL CO.,LTD | +86-0512-83500002 +8618662433356 | 3899766280@qq.com | China | 26362 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43333 | 58 |
| XIAMEN AMITY INDUSTRY AND TRADE CO., LTD. | +8618950047208 | ellena@amitychem.com | China | 43414 | 58 |
| Beijing HuaMeiHuLiBiological Chemical | 010-56205725 | waley188@sohu.com | China | 12335 | 58 |
| Shandong Xiya Chemical Co., Ltd. | 4009903999 13395398332 | sales@xiyashiji.com | China | 20794 | 60 |
| Raw material medicin reagent co.,Ltd | sales@njromanme.com | China | 4529 | 58 | |
| Lynnchem | 86-(0)29-85992781 17792393971 | info@lynnchem.com | China | 4587 | 58 |
| Novachemistry | 44-20819178-90 02081917890 | info@novachemistry.com | United Kingdom | 4381 | 58 |
View Lastest Price from BLASTICIDIN S manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-05-26 | Blasticidin S
2079-00-7
|
1KG | 99.0% | 500 MT | Shaanxi Dideu Medichem Co. Ltd | ||
 |
2019-12-23 | BLASTICIDIN S
2079-00-7
|
$1.00 | 1KG | 98 | 10t | Career Henan Chemical Co |
-
- Blasticidin S
2079-00-7
- 99.0%
- Shaanxi Dideu Medichem Co. Ltd
-
- BLASTICIDIN S
2079-00-7
- $1.00
- 98
- Career Henan Chemical Co
