5-Hydroxymethylpyrrolidin-2-one
- CAS No.
- 66673-40-3
- Chemical Name:
- 5-Hydroxymethylpyrrolidin-2-one
- Synonyms
- D-PYROGLUTAMINOL;D-Pyr-ol;H-D-Pyr-ol;(-)-D-PYROGLUTAMOL;(R)-(-)-5-(HydroxymethyL;5-Hydroxymethylpyrrolidin-2-one;5-(Hydroxymethyl)-2-pyrrolidinone;(R)-(-)-2-PYRROLIDONE-5-YL-METHANOL;(R)-5-HYDROXYMETHYL-PYRROLIDIN-2-ONE;(R)-5-(HYDROXYMETHYL)-2-PYRROLIDINONE
- CBNumber:
- CB2304847
- Molecular Formula:
- C5H9NO2
- Molecular Weight:
- 115.13
- MDL Number:
- MFCD00077791
- MOL File:
- 66673-40-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| (R)-(?)-5-(Hydroxymethyl)-2-pyrrolidinone 99% | 366358 | 1g | $45.1 |
| (R)-(?)-5-(Hydroxymethyl)-2-pyrrolidinone 99% | 366358 | 5g | $177 |
| (R)-5-(Hydroxymethyl)-2-pyrrolidinone >98.0%(GC)(N) | H1241 | 1g | $57 |
| (R)-5-(Hydroxymethyl)-2-pyrrolidinone >98.0%(GC)(N) | H1241 | 5g | $158 |
| (R)-(-)-5-(Hydroxymethyl)-2-pyrrolidinone | H9110-15M | 1g | $319 |
| More product size | |||
| Melting point | 83-85 °C(lit.) |
|---|---|
| Boiling point | 147-149 °C0.06 mm Hg(lit.) |
| Density | 1.1808 (rough estimate) |
| refractive index | -31 ° (C=5, EtOH) |
| Flash point | 147-149°C/0.06m |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Chloroform, Dimethylformamide, Water |
| pka | 14.35±0.10(Predicted) |
| form | Crystalline Powder or Flakes |
| color | White to yellow |
| optical activity | [α]20/D 31°, c = 5 in ethanol |
| BRN | 5728422 |
| InChI | 1S/C5H9NO2/c7-3-4-1-2-5(8)6-4/h4,7H,1-3H2,(H,6,8)/t4-/m1/s1 |
| InChIKey | HOBJEFOCIRXQKH-SCSAIBSYSA-N |
| SMILES | OC[C@H]1CCC(=O)N1 |
| CAS DataBase Reference | 66673-40-3(CAS DataBase Reference) |
| UNSPSC Code | 12352005 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 3-10 | |||||||||
| HS Code | 29337900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
5-Hydroxymethylpyrrolidin-2-one price More Price(83)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 366358 | (R)-(?)-5-(Hydroxymethyl)-2-pyrrolidinone 99% | 66673-40-3 | 1g | $45.1 | 2023-06-20 | Buy |
| Sigma-Aldrich | 366358 | (R)-(?)-5-(Hydroxymethyl)-2-pyrrolidinone 99% | 66673-40-3 | 5g | $177 | 2023-06-20 | Buy |
| TCI Chemical | H1241 | (R)-5-(Hydroxymethyl)-2-pyrrolidinone >98.0%(GC)(N) | 66673-40-3 | 1g | $57 | 2026-04-30 | Buy |
| TCI Chemical | H1241 | (R)-5-(Hydroxymethyl)-2-pyrrolidinone >98.0%(GC)(N) | 66673-40-3 | 5g | $158 | 2026-04-30 | Buy |
| Usbiological | H9110-15M | (R)-(-)-5-(Hydroxymethyl)-2-pyrrolidinone | 66673-40-3 | 1g | $319 | 2026-06-03 | Buy |
5-Hydroxymethylpyrrolidin-2-one Chemical Properties,Uses,Production
Chemical Properties
(R)-5-(Hydroxymethyl)-2-pyrrolidinone is White Powder
Uses
(R)-5-(Hydroxymethyl)-2-pyrrolidinone is a 2-pyrrolidone derivative for therapeutic use as prostanoid receptor agonist.
Uses
Serves as a building block in the synthesis of diphthamide.
Synthesis
64700-65-8
66673-40-3
Scheme 1, Step B: Preparation of (R)-(-)-5-(hydroxymethyl)-2-pyrrolidinone (3) To a solution of methanol (100 mL) containing methyl (R)-5-oxopyrrolidine-2-carboxylate (Intermediate 2, 13.2 g), sodium borohydride (10.5 g, 278 mmol) was added in batches at 0 °C. The reaction mixture was stirred continuously at 0 °C until the reaction was complete, followed by the addition of acetic acid (3 mL) to quench the reaction. The reaction mixture was concentrated and the residue was purified by silica gel column chromatography using methanol-chloroform (1:9, v/v) as eluent to afford the target product (12.9 g, 97% yield) as a colorless solid. Thin-layer chromatography (TLC) showed an Rf value of 0.33 (unfolding agent system: methanol-chloroform, 1:9, v/v); nuclear magnetic resonance hydrogen spectrum (1H-NMR, CDCl3) δ: 7.17 (s, 1H), 3.92 (s, 1H), 3.85-3.75 (m, 1H), 3.64-3.40 (m, 2H), 2.42-2.35 (m. 2H), 2.2-2.05 (m, 1H), 1.88-1.7 (m, 1H).
References
[1] Patent: WO2014/15246, 2014, A1. Location in patent: Paragraph 0447-0448
[2] Patent: WO2014/144610, 2014, A1. Location in patent: Paragraph 0368; 0377; 0378
[3] Patent: WO2015/9991, 2015, A2. Location in patent: Paragraph 0555-0556
[4] Patent: US2016/60216, 2016, A1. Location in patent: Paragraph 0371-0372
[5] Patent: KR2015/130326, 2015, A. Location in patent: Page/Page column 0409-0411
5-Hydroxymethylpyrrolidin-2-one Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sichuan HongRi Pharma-Tech Co.,Ltd | +8618382028708 | ni@enlaibio.com | China | 1100 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20122 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
View Lastest Price from 5-Hydroxymethylpyrrolidin-2-one manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-05 | D-Pyr-ol
66673-40-3
|
1kg | 98% | 1T+ | Sichuan HongRi Pharma-Tech Co.,Ltd | ||
 |
2025-09-25 | (R)-(-)-5-(Hydroxymethyl)-2-pyrrolidinone
66673-40-3
|
$1.00-200.00 | 1KG | 99%, 99.5% Sublimated | Henan Fengda Chemical Co., Ltd | ||
 |
2021-07-02 | 5-Hydroxymethylpyrrolidin-2-one
66673-40-3
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- D-Pyr-ol
66673-40-3
- 98%
- Sichuan HongRi Pharma-Tech Co.,Ltd
-
- (R)-(-)-5-(Hydroxymethyl)-2-pyrrolidinone
66673-40-3
- $1.00-200.00
- 99%, 99.5% Sublimated
- Henan Fengda Chemical Co., Ltd
-
- 5-Hydroxymethylpyrrolidin-2-one
66673-40-3
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
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