2,6-DIFLUORO-4-METHOXYBENZALDEHYDE
- CAS No.
- 256417-10-4
- Chemical Name:
- 2,6-DIFLUORO-4-METHOXYBENZALDEHYDE
- Synonyms
- 5-Fluoroacetophenone;2,6-fluoro-4-methoxybenzaldehyde;,6-DIFLUORO-4-METHOXYBENZALDEHYDE;2,6-DIFLUORO-4-METHOXYBENZALDEHYDE;Benzaldehyde, 2,6-difluoro-4-methoxy-;2,6-Difluoro-4-methoxybenzaldehyde 98%;2,6-DIFLUORO-4-METHOXYBENZALDEHYDE ISO 9001：2015 REACH;3,5-Difluoro-4-formylanisole, 2,6-Difluoro-p-anisaldehyde
- CBNumber:
- CB2330994
- Molecular Formula:
- C8H6F2O2
- Molecular Weight:
- 172.13
- MDL Number:
- MFCD04114368
- MOL File:
- 256417-10-4.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 2,6-Difluoro-4-methoxybenzaldehyde Asreported | 160020 | 2.5g | $425 |
| 2,6-Difluoro-4-methoxybenzaldehyde 98% | AS35171 | 1g | $27 |
| 2,6-Difluoro-4-methoxybenzaldehyde 98% | AS35171 | 5g | $49 |
| 2,6-Difluoro-4-methoxybenzaldehyde 98% | AS35171 | 25g | $136 |
| 2,6-Difluoro-4-methoxybenzaldehyde 98% | AS35171 | 100g | $383 |
| More product size | |||
| Melting point | 73-77 °C(lit.) |
|---|---|
| Boiling point | 207.1±35.0 °C(Predicted) |
| Density | 1.289±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | solid |
| color | Faint Gold |
| Sensitive | Air Sensitive |
| InChI | 1S/C8H6F2O2/c1-12-5-2-7(9)6(4-11)8(10)3-5/h2-4H,1H3 |
| InChIKey | ZYABCGOTMDPUDD-UHFFFAOYSA-N |
| SMILES | COc1cc(F)c(C=O)c(F)c1 |
| CAS DataBase Reference | 256417-10-4(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H319-H335-H315-H318 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P405-P501a-P280-P305+P351+P338 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 38-41 | |||||||||
| Safety Statements | 26-36/37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29130000 | |||||||||
| Storage Class | 13 - Non Combustible Solids | |||||||||
| Hazard Classifications | Eye Dam. 1 Skin Irrit. 2 |
|||||||||
| NFPA 704 |
|
2,6-DIFLUORO-4-METHOXYBENZALDEHYDE price More Price(68)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 160020 | 2,6-Difluoro-4-methoxybenzaldehyde Asreported | 256417-10-4 | 2.5g | $425 | 2026-06-03 | Buy |
| Activate Scientific | AS35171 | 2,6-Difluoro-4-methoxybenzaldehyde 98% | 256417-10-4 | 1g | $27 | 2026-06-04 | Buy |
| Activate Scientific | AS35171 | 2,6-Difluoro-4-methoxybenzaldehyde 98% | 256417-10-4 | 5g | $49 | 2026-06-04 | Buy |
| Activate Scientific | AS35171 | 2,6-Difluoro-4-methoxybenzaldehyde 98% | 256417-10-4 | 25g | $136 | 2026-06-04 | Buy |
| Activate Scientific | AS35171 | 2,6-Difluoro-4-methoxybenzaldehyde 98% | 256417-10-4 | 100g | $383 | 2026-06-04 | Buy |
2,6-DIFLUORO-4-METHOXYBENZALDEHYDE Chemical Properties,Uses,Production
Uses
2,6-Difluoro-4-methoxybenzaldehyde, is a versatile building block used for the synthesis of more complex pharmaceutical and biologically active compounds. It is shown to be involved in the preparation of potent and orally available G protein-coupled receptor 40 agonists, used the treatment of type 2 diabetes.
Synthesis
4885-02-3
93343-10-3
608515-57-7
256417-10-4
The general procedure for the synthesis of 2,4-difluoro-6-methoxybenzaldehyde (Intermediate 26B) and 2,6-difluoro-4-methoxybenzaldehyde (Intermediate 26A) from 1,1-dichlorodimethyl ether and 3,5-difluoroanisole is as follows (Intermediates 26A and 26B were prepared similarly to the method described in WO 2004046133): to a stirred 3 ,5-difluoroanisole (1.0 g, 7.0 mmol) to a stirred solution of dichloromethane (6 mL) was slowly added titanium tetrachloride (1.23 mL, 11.2 mmol) and dichloromethyl methyl ether (0.63 mL, 7.0 mmol) dropwise. After the dropwise addition was completed, the reaction mixture was continued to be stirred for 1 hour and subsequently poured into ice water (50 mL). The reaction mixture was extracted with dichloromethane (3 x 50 mL). The organic phases were combined, washed sequentially with H2O (50 mL) and brine (50 mL), dried with Na2SO4 and filtered. The solvent was removed by concentration under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography with 0 to 20% EtOAc/hexane as eluent to isolate 2,6-difluoro-4-methoxybenzaldehyde (Intermediate 26A, less polar component, 230 mg, 19% yield) and 2,4-difluoro-6-methoxybenzaldehyde (Intermediate 26B, more polar component, 740 mg, 62% yield), both as a white solid. 1H NMR (400 MHz, CDCl3) data of intermediate 26A: δ 3.85 (s, 3H), 6.47 (d, J=10.55Hz, 2H), 10.17 (s, 1H). 1H NMR (400MHz, CDCl3) data for intermediate 26B: δ 3.91 (s, 3H), 6.43-6.51 (m, 2H), 10.30 (s, 1H).
References
[1] Patent: WO2007/30582, 2007, A2. Location in patent: Page/Page column 90
2,6-DIFLUORO-4-METHOXYBENZALDEHYDE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10403 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Shenzhen Excellent Biotech Co., Ltd. | 13480692018 | ramyan@ex-biotech.com | CHINA | 954 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10000 | 58 |
View Lastest Price from 2,6-DIFLUORO-4-METHOXYBENZALDEHYDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-03-20 | 2,6-DIFLUORO-4-METHOXYBENZALDEHYDE
256417-10-4
|
1KG | 99% | 20 mt | Hebei Chuanghai Biotechnology Co., Ltd | ||
 |
2025-11-18 | 2,6-DIFLUORO-4-METHOXYBENZALDEHYDE
256417-10-4
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2020-01-08 | ,6-DIFLUORO-4-METHOXYBENZALDEHYDE
256417-10-4
|
$2.00 | 1g | 98%MIN | Career Henan Chemical Co |
-
- 2,6-DIFLUORO-4-METHOXYBENZALDEHYDE
256417-10-4
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 2,6-DIFLUORO-4-METHOXYBENZALDEHYDE
256417-10-4
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- ,6-DIFLUORO-4-METHOXYBENZALDEHYDE
256417-10-4
- $2.00
- 98%MIN
- Career Henan Chemical Co
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