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COUMESTROL

COUMESTROL structure

CAS No.: 479-13-0

Chemical Name:: COUMESTROL

Synonyms: Coumesterol;3,9-Dihydroxy-6H-[1]benzofuro[3,2-c]chromen-6-one;Nsc22842;Cumostrol;Cumoestrol;COUMESTROL;COUMOESTROL;cumoesterol;COUMESTROL(P);Coumestrol,99%

CBNumber:: CB2339816

Molecular Formula:: C15H8O5

Molecular Weight:: 268.22

MDL Number:: MFCD00016885

MOL File:: 479-13-0.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-07-14 16:49:18

Product description	Number	Pack Size	Price
Coumestrol BioReagent, suitable for fluorescence, ≥97.5% (HPLC)	27883	5mg	$352
Coumestrol BioReagent, suitable for fluorescence, ≥97.5% (HPLC)	27883	1mg	$105
Coumestrol ≥98%	11730	1mg	$49
Coumestrol ≥98%	11730	5mg	$103
Coumestrol ≥98%	11730	10mg	$169
More product size

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COUMESTROL Properties

Melting point	≥350 °C(lit.)
Boiling point	331.39°C (rough estimate)
Density	1.2586 (rough estimate)
refractive index	1.7680 (estimate)
storage temp.	Refrigerator
solubility	DMSO: soluble
form	Light beige solid.
pka	8.25±0.20(Predicted)
color	Pale Yellow to Dark Brown
BRN	266702
InChI	InChI=1S/C15H8O5/c16-7-1-3-9-11(5-7)19-14-10-4-2-8(17)6-12(10)20-15(18)13(9)14/h1-6,16-17H
InChIKey	ZZIALNLLNHEQPJ-UHFFFAOYSA-N
SMILES	C1(=O)OC2=CC(O)=CC=C2C2OC3=CC(O)=CC=C3C1=2
LogP	2.940 (est)
CAS DataBase Reference	479-13-0(CAS DataBase Reference)
NCI Dictionary of Cancer Terms	coumestrol
FDA UNII	V7NW98OB34
EPA Substance Registry System	Coumestrol (479-13-0)
UNSPSC Code	41116107
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P264-P270-P301+P312-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

22-36/37/38

Safety Statements

26-36

WGK Germany

RTECS

DF8077000

TSCA

TSCA listed

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	0
2		0

COUMESTROL price More Price(84)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	27883	Coumestrol BioReagent, suitable for fluorescence, ≥97.5% (HPLC)	479-13-0	5mg	$352	2026-04-30	Buy
Sigma-Aldrich	27883	Coumestrol BioReagent, suitable for fluorescence, ≥97.5% (HPLC)	479-13-0	1mg	$105	2025-07-31	Buy
Cayman Chemical	11730	Coumestrol ≥98%	479-13-0	1mg	$49	2026-04-30	Buy
Cayman Chemical	11730	Coumestrol ≥98%	479-13-0	5mg	$103	2026-04-30	Buy
Cayman Chemical	11730	Coumestrol ≥98%	479-13-0	10mg	$169	2026-04-30	Buy

Product number	Packaging	Price	Buy
27883	5mg	$352	Buy
27883	1mg	$105	Buy
11730	1mg	$49	Buy
11730	5mg	$103	Buy
11730	10mg	$169	Buy

COUMESTROL Chemical Properties,Uses,Production

Description

Coumestrol is a phytoestrogen that occurs naturally in soybeans, spinach, and clover. It competitively (vs. 17β-estradiol, ) binds the estrogen receptors ERα (IC₅₀ = 11 nM) and ERβ (IC₅₀ = 2 nM) and can induce ER-dependent gene expression in isolated cells. Coumestrol is also a weak antagonist of pregnane X receptor (IC₅₀ = 12 μM) as well as a potential inverse agonist of the constitutive androstane receptor (EC₅₀ = 30 μM).

Chemical Properties

Yellow to Beige Powder

Uses

This compound has estrogenic activity. It exhibits bright blue fluorescence in neutral or acid solution, and greenish-yellow fluorescence in strong alkali solution.

Definition

ChEBI: A member of the class of coumestans that is coumestan with hydroxy substituents at positions 3 and 9.

Synthesis Reference(s)

Tetrahedron Letters, 4, p. 1151, 1963 DOI: 10.1039/jr9630005127

Biochem/physiol Actions

Coumestrol has anti-estrogenic actions in the brain and pituitary, mediated through estrogen receptor-α.

Safety Profile

An experimental teratogen. Other experimental reproductive effects. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.

References

[1]. chen hy, dykstra kd, birzin et, et al. estrogen receptor ligands. part 1: the discovery of flavanoids with subtype selectivity. bioorg med chem lett. 2004 mar 22;14(6):1417-21.
[2]. hopert ac, beyer a, frank k, et al. characterization of estrogenicity of phytoestrogens in an endometrial-derived experimental model. environ health perspect. 1998 sep;106(9):581-6.
[3]. wang h, li h, moore lb, et al. the phytoestrogen coumestrol is a naturally occurring antagonist of the human pregnane x receptor. mol endocrinol. 2008 apr;22(4):838-57.

COUMESTROL Preparation Products And Raw materials

Raw materials

Preparation Products

COUMESTROL Suppliers

Global( 186)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shaanxi Dideu Medichem Co. Ltd	+86-29-81139210 17389186172	1077@dideu.com	China	3796	58
Shanghai Zheyan Biotech Co., Ltd.	18017610038	zheyansh@163.com	CHINA	3619	58
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29812	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569262 +86-15003564040	1056@dideu.com	China	3970	58
Antai Fine Chemical Technology Co.,Limited	18503026267	info@antaichem.com	CHINA	9636	58
Wuhan ChemNorm Biotech Co.,Ltd.	+86-27-8439 4403 18971486879	sales@chemnorm.com	CHINA	2935	58
Finetech Industry Limited	+86-27-8746-5837 +8619945049750	info@finetechnology-ind.com	China	9539	58
sgtlifesciences pvt ltd	+8617013299288	dj@sgtlifesciences.com	China	12373	58
TargetMol Chemicals Inc.	+1-781-999-5354;	support@targetmol.com	United States	39037	58
SUZHOU SENFEIDA CHEMICAL CO.,LTD	+86-0512-83500002 +8618662433356	3899766280@qq.com	China	26362	58

Supplier	Advantage
Shaanxi Dideu Medichem Co. Ltd	58
Shanghai Zheyan Biotech Co., Ltd.	58
career henan chemical co	58
Shaanxi Dideu Medichem Co. Ltd	58
Antai Fine Chemical Technology Co.,Limited	58
Wuhan ChemNorm Biotech Co.,Ltd.	58
Finetech Industry Limited	58
sgtlifesciences pvt ltd	58
TargetMol Chemicals Inc.	58
SUZHOU SENFEIDA CHEMICAL CO.,LTD	58

View Lastest Price from COUMESTROL manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-07-14	Coumestrol 479-13-0	$40.00-123.00		98.85%	10g	TargetMol Chemicals Inc.
2026-02-02	CouMestrol 479-13-0		5mg	99%HPLC	2000tons	Shaanxi Dideu Medichem Co. Ltd
2025-12-12	COUMESTROL 479-13-0	$1.00-4.00	1KG	99%	200000KG	Shaanxi Dideu Medichem Co. Ltd

Coumestrol
479-13-0
$40.00-123.00
98.85%
TargetMol Chemicals Inc.

CouMestrol
479-13-0
99%HPLC
Shaanxi Dideu Medichem Co. Ltd

COUMESTROL
479-13-0
$1.00-4.00
99%
Shaanxi Dideu Medichem Co. Ltd

COUMESTROL Spectrum

COUMESTROL(479-13-0)¹HNMR

479-13-0(COUMESTROL)Related Search:

BAVACHININ A 8-Prenyldaidzein 1-[2-Hydroxy-4-methoxy-5-(3-methyl-2-butenyl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one 7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol WEDELOLACTONE

psoralidin 3-HYDROXY-8,9-METHYLENEDIOXYCOUMESTAN COUMESTROL demethylwedelolactone 3-HYDROXY-9-METHOXYCOUMESTAN

neoglycyrol COUMESTROL DIMETHYL ETHER,COUMESTROL DIMETHYL ETHER, FOR FLUORESCE 4'-ORTHO-METHYL-COUMESTROL COUMESTROL DIACETATE MEDICAGO COUMESTROL 10%

COUMESTROL(RG) COUMESTROL DIACETATE, FOR FLUORESCENCE* TRIFOLIOL

1of4

cumoesterol COUMOESTROL 7 12-DIHYDROXYCOUMESTAN 98% COUMESTROL(P) 2-(2 4-DIHYDROXYPHENYL)-6-HYDROXY-3-BENZOFURANCARBOXYLIC ACID D-LACTONE 98% Coumestrol,99% 3-Benzofurancarboxylic acid, 2-(2,4-dihydroxyphenyl)-6-hydroxy-, .delta.-lactone 6H-Benzofuro[3,2-C][1]benzopyran-6-one, 3,9-dihydroxy- Cumoestrol Cumostrol Nsc22842 2-(2,4-Dihydroxyphenyl)-6-hydroxy-3-benzofurancarboxylic Acid δ-Lactone 7,12-DIHYDROXYCOUMESTAN 7,12-DIHYDROXYCOUMESTANE 7(1), 6-DIHYDROXYCOUMARINO(3(1), 4(1), 3,2)COUMARONE [2-(2,4-DIHYDROXYPHENYL)-6-HYDROXY-3-BENZOFURAN-CARBOXYLIC ACID ALPHA-LACTONE] 2-(2,4-DIHYDROXYPHENYL)-6-HYDROXY-3-BENZOFURANCARBOXYLIC ACID DELTA-LACTONE 2-(2 4-DIHYDROXYPHENYL)-6-HYDROXY-3-BENZOFURANCARBOXYLIC ACID D-LACTONE COUMESTROL COUMESTROL BIOREAGENT, SUITABLE FOR 3,9-DIHYDROXY-6H-BENZOFURO[3,2-C]-[1]BENZOPYRAN-6-ONE 2-(2,4-dihydroxyphenyl)-6-hydroxy-3-benzofurancarboxylicacidelta-lacton 2-c)(1)benzopyran-6-one,3,9-dihydroxy-6h-benzofuro( 2-c][1]benzopyran-6-one,3,9-dihydroxy-6h-benzofuro[ Coumestrol, >98% 3,9-dihydroxy-6-benzofuro[3,2-c][1]benzopyranone Coumestrol ( synthitic) 3,9-Dihydroxy-6H-benzofuro[3,2-c]chromen-6-one Coumestrol (Synthetic) 5,14-dihydroxy-8,17-dioxatetracyclo[8.7.0.02,?.011,1?]heptadeca-1(10),2(7),3,5,11(16),12,14-heptaen-9-one 7’, 6-Dihydroxycoumarino(3’, 4’, 3, 2)Coumarone Coumestrol, 10 mM in DMSO Coumestrol[27885] 3,9-Dihydroxy-6H-benzofuro[3,2-c]chromen-6-one , Coumestrol 3,9-Dihydroxy-6H-[1]benzofuro[3,2-c]chromen-6-one Coumesterol 479-13-0 C15H9O5 C15H8O5 Steroids & Hormones - 13C & 2H Steroids Coumarins Iso-Flavones

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