4-BOC-2-MORPHOLINECARBOXYLIC ACID
- CAS No.
- 189321-66-2
- Chemical Name:
- 4-BOC-2-MORPHOLINECARBOXYLIC ACID
- Synonyms
- 4-(TERT-BUTOXYCARBONYL)MORPHOLINE-2-CARBOXYLIC ACID;BOC-COP-OH;BOC-COP;Boc-(R,S)-Cop-OH;RARECHEM EM WB 0087;Boc-2-carboxymorpholine;(R,S)-BOC-2-CARBOXYMORPHOLINE;BOC-(R,S)-2-CARBOXYMORPHOLINE;N-Boc-2-morpholinecarboxylic acid;4-BOC-2-MORPHOLINECARBOXYLIC ACID
- CBNumber:
- CB2410841
- Molecular Formula:
- C10H17NO5
- Molecular Weight:
- 231.25
- MDL Number:
- MFCD01321006
- MOL File:
- 189321-66-2.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Boc-(R,S)-2-carboxymorpholine | 265196 | 500mg | $333 |
| Boc-(R,S)-2-carboxymorpholine | 265196 | 1g | $470 |
| Boc-(R,S)-2-carboxymorpholine | 265196 | 2g | $632 |
| Boc-(R,S)-2-carboxymorpholine | 265196 | 5g | $894 |
| Boc-(R,S)-2-carboxymorpholine | 265196 | 10g | $1168 |
| More product size | |||
| Melting point | >139oC (dec.) |
|---|---|
| Boiling point | 369.5±42.0 °C(Predicted) |
| Density | 1.230±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | DMSO (Slightly), Ethyl Acetate (Slightly, Heated) |
| form | Solid |
| pka | 3.25±0.20(Predicted) |
| color | Off-White to Pale Beige |
| InChI | InChI=1S/C10H17NO5/c1-10(2,3)16-9(14)11-4-5-15-7(6-11)8(12)13/h7H,4-6H2,1-3H3,(H,12,13) |
| InChIKey | LGWMTRPJZFEWCX-UHFFFAOYSA-N |
| SMILES | N1(C(OC(C)(C)C)=O)CCOC(C(O)=O)C1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P271-P280 |
| Hazard Codes | Xi |
| Risk Statements | 36-51 |
| Safety Statements | 26 |
| HS Code | 29334900 |
4-BOC-2-MORPHOLINECARBOXYLIC ACID price More Price(88)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 265196 | Boc-(R,S)-2-carboxymorpholine | 189321-66-2 | 500mg | $333 | 2026-06-03 | Buy |
| Usbiological | 265196 | Boc-(R,S)-2-carboxymorpholine | 189321-66-2 | 1g | $470 | 2026-06-03 | Buy |
| Usbiological | 265196 | Boc-(R,S)-2-carboxymorpholine | 189321-66-2 | 2g | $632 | 2026-06-03 | Buy |
| Usbiological | 265196 | Boc-(R,S)-2-carboxymorpholine | 189321-66-2 | 5g | $894 | 2026-06-03 | Buy |
| Usbiological | 265196 | Boc-(R,S)-2-carboxymorpholine | 189321-66-2 | 10g | $1168 | 2026-06-03 | Buy |
4-BOC-2-MORPHOLINECARBOXYLIC ACID Chemical Properties,Uses,Production
Chemical Properties
4-BOC-2-MORPHOLINECARBOXYLIC ACID is white to off-white powder
Uses
4-BOC-2-MORPHOLINECARBOXYLIC ACID is used in the preparation of potent and selective 3-phosphoinositide-dependent kinase 1 (PDK 1) inhibitors used in the treatment of multipl e myelomas.
Uses
4-(1,1-Dimethylethyl) Ester 2,4-Morpholinedicarboxylic Acid is used in the preparation of potent and selective 3-phosphoinositide-dependent kinase 1 (PDK 1) inhibitors used in the treatment of multiple myelomas.
Synthesis
500789-41-3
189321-66-2
Methyl 4-(tert-butoxycarbonyl)morpholine-2-carboxylate (251 mg, 1.02 mmol) was used as a raw material and dissolved in methanol (15 mL). To this solution was added 1 mol/L aqueous potassium hydroxide solution (3 mL). The reaction mixture was stirred at room temperature for 8 hours. Upon completion of the reaction, water was added to the mixture and the pH was adjusted with 5% aqueous citric acid solution. subsequently, the reaction mixture was extracted with ethyl acetate. The organic phase was washed with saturated brine and dried with anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to give 219 mg (93% yield) of the target product 4-Boc-2-morpholinecarboxylic acid as a colorless powder. The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ1.40 (9H, s), 2.70 (1H, dd, J=41.6,15.3 Hz), 3.03-3.09 (1H, m), 3.43-3.54 (2H, m), 3.78 (1H, m), 3.85 (1H, dt, J=11.6,3.7 Hz), 4.04 (1H, dd, J=8.6,3.7Hz), 12.73 (1H, brs).
References
[1] Patent: EP1780210, 2007, A1. Location in patent: Page/Page column 58
4-BOC-2-MORPHOLINECARBOXYLIC ACID Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10000 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| JIAXING REGEN CHEMICAL CO.,LTD | +8613385739570 | regen_chemical1@163.com | China | 226 | 58 |
| Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | sales@win-winchemical.com | China | 14304 | 58 |
| Blocksynth Pharmaceutical Technology Co.,Ltd | 0086-19817745290; +8619817745290 | bd@blocksynth.com | China | 5973 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
View Lastest Price from 4-BOC-2-MORPHOLINECARBOXYLIC ACID manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-04 | 4-BOC-2-MORPHOLINECARBOXYLIC ACID
189321-66-2
|
1KG | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | ||
 |
2019-09-05 | 4-BOC-2-MORPHOLINECARBOXYLIC ACID
189321-66-2
|
$5.00 | 1KG | 95%-98% | 100kg | Career Henan Chemical Co |
-
- 4-BOC-2-MORPHOLINECARBOXYLIC ACID
189321-66-2
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 4-BOC-2-MORPHOLINECARBOXYLIC ACID
189321-66-2
- $5.00
- 95%-98%
- Career Henan Chemical Co
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