NONACTIN
- CAS No.
- 6833-84-7
- Chemical Name:
- NONACTIN
- Synonyms
- 3584-a;a-5584;e-79-c;n-329-a;NONACTIN;ta-25-m-i;fh-3582-a;POLYNACTIN;WERRAMYCIN A;AMMONIUM IONOPHORE
- CBNumber:
- CB2424675
- Molecular Formula:
- C40H64O12
- Molecular Weight:
- 736.93
- MDL Number:
- MFCD00043039
- MOL File:
- 6833-84-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Ammonium ionophore I Selectophore | 09877 | 50mg | $430 |
| Ammonium ionophore I Selectophore | 09877 | 250mg | $1960 |
| Nonactin, Monactin, and Dinactin Mixture ≥95%(mixtureofhomologues) | 19468 | 5mg | $54 |
| Nonactin, Monactin, and Dinactin Mixture ≥95%(mixtureofhomologues) | 19468 | 10mg | $96 |
| Nonactin, Monactin, and Dinactin Mixture ≥95%(mixtureofhomologues) | 19468 | 25mg | $209 |
| More product size | |||
| Melting point | 147-148° |
|---|---|
| Boiling point | 890.6±65.0 °C(Predicted) |
| Density | 1.11-1.15 g/cm3 |
| storage temp. | 2-8°C |
| solubility | chloroform: soluble10mg/mL |
| form | White to off-white crystalline solid. |
| color | white to faint yellow |
| Sensitive | Moisture Sensitive |
| Merck | 13,6709 |
| BRN | 76434 |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months. |
| InChIKey | RMIXHJPMNBXMBU-QIIXEHPYSA-N |
| EWG's Food Scores | 1 |
| FDA UNII | TTP24WX8P7 |
| UNSPSC Code | 26111700 |
| NACRES | NB.61 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P271-P280 |
| PPE | Eyeshields, Gloves, type N95 (US) |
| Hazard Codes | Xi |
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
| RTECS | RH1685000 |
| F | 10-21 |
| HS Code | 29321900 |
| Storage Class | 11 - Combustible Solids |
| Toxicity | LD50 intravenous in mouse: 246mg/kg |
NONACTIN price More Price(50)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 09877 | Ammonium ionophore I Selectophore | 6833-84-7 | 50mg | $430 | 2026-04-30 | Buy |
| Sigma-Aldrich | 09877 | Ammonium ionophore I Selectophore | 6833-84-7 | 250mg | $1960 | 2026-04-30 | Buy |
| Cayman Chemical | 19468 | Nonactin, Monactin, and Dinactin Mixture ≥95%(mixtureofhomologues) | 5mg | $54 | 2026-04-30 | Buy | |
| Cayman Chemical | 19468 | Nonactin, Monactin, and Dinactin Mixture ≥95%(mixtureofhomologues) | 10mg | $96 | 2026-04-30 | Buy | |
| Cayman Chemical | 19468 | Nonactin, Monactin, and Dinactin Mixture ≥95%(mixtureofhomologues) | 25mg | $209 | 2026-04-30 | Buy |
NONACTIN Chemical Properties,Uses,Production
Description
Nonactin (6833-84-7) is a monovalent cation ionophore with high selectivity for NH4+ and K+ .1 Upregulates levels of mitochondrial stress proteins HSP58 and GRP75.2 Nonactin abolishes mitochondrial membrane potential.3
Chemical Properties
Light yellow powder
Uses
Nonactin is an ionophore antiobiotic that selectively binds K+and NH4+.
Uses
Nonactin is the smallest member of the macrotetrolide complex produced by a range of Streptomyces species. Originally the name, nonactin, reflected the lack of biological activity. The literature is confusing in this respect, as virtually all sources of nonactin are contaminated with small amounts of the much more active monactin. The BioAustralis nonactin has been purified to remove traces of other biologically-active macrotetrolides. Like the other macrotetrolides, nonactin is a monovalent cation ionophore with high selectivity for ammonium and potassium.
Definition
ChEBI: Nonactin is a macrotetrolide.
Biological Activity
Monovalent cation ionophore that displays selectivity for K + and NH 4 + (K + = NH 4 + > Na + > Mg 2+ > Li + >> Ca 2+ for nonactin-EVA sensor). Induces cation transport across artificial membranes. Also inhibits P-glycoprotein-mediated efflux of chemotherapeutic agents in multiple-drug resistant cancer cells. Antibiotic.
Purification Methods
This macrotetrolide antibiotic crystallises from MeOH as colourless needles and is dried at 90o/20hours/high vacuum. [Cordaz et al. Helv Chim Acta 38 1445 1955, crystal structure: Dobler Helv Chim Acta 55 1371 1972, Gambos et al. Tetrahedron Lett 3391 1975, Beilstein 19/12 V 751.]
Background
The antibiotic Nonactin is an ionophore that binds and transports monovalent cations across membranes through passive diffusion. Nonactin displays both antibacterial and anti-tumor activities, and inhibits drug efflux in multiple drug resistant cancers. Naturally occurring Nonactin is composed of four monomers of Nonactic acid, comprised of an equal number of and monomers. The antibiotic properties of Nonactin result from its ability to form stable complexes with monovalent cations; artificial Nonactin tetramers, comprised of either all or all Nonactic acid monomers, lack ion binding ability and are less potent antibiotics. Treatment of erythrocytes with Nonactin leads to suicidal erythrocyte death as evidenced by the shrinking of erythrocytes and translocation of phosphatidylserine from the erythrocyte interior to the cell surface. Nonactin selectively induces apoptosis and results in tumor regression in a β-catenin mutant HCT 116 xenograft model, and can inhibit the surface expression of endogenous HSP60.
References
[1] CARLOS ALEXANDRE BORGES GARCIA Graciliano de O N Laércio Rover Júnior. Determination of potassium ions in pharmaceutical samples by FIA using a potentiometric electrode based on ionophore nonactin occluded in EVA membrane[J]. Journal of pharmaceutical and biomedical analysis, 2003, 31 1: Pages 11-18. DOI:10.1016/s0731-7085(02)00598-8
[2] L. MIZZEN. Identification, characterization, and purification of two mammalian stress proteins present in mitochondria, grp 75, a member of the hsp 70 family and hsp 58, a homolog of the bacterial groEL protein.[J]. The Journal of Biological Chemistry, 1989, 8 1: 20664-20675. DOI:10.1016/s0021-9258(19)47115-9
[3] A K DUDANI. Effects of antimitotic and antimitochondrial agents on the cellular distribution of microtubules and mitochondria.[J]. Cytobios, 1990, 63 253: 95-108.
NONACTIN Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 9996 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19853 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +86-571-86217390; +8618058761490 | info@gihichemicals.com | China | 49969 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501; +undefined18621343501 | product@acmec-e.com | China | 33324 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | cooperation@kean-chem.com | China | 40066 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532; 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15838 | 69 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9416 | 55 |
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