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ChemicalBook >> CAS DataBase List >>STAUROSPORINE

STAUROSPORINE

CAS No.
62996-74-1
Chemical Name:
STAUROSPORINE
Synonyms
Staurosporin;STSP;AM-2282;Stauroporine;Staurosporine,98%;2,3,10,11,12,13-HEXAHYDRO-10R-METHOXY-9S-METHYL-11R-METHYLAMINO-9S,13R-EPOXY-1H,9H-DIINDOLO[1,2,3-GH:3',2',1'-LM]PYRROLO[3,4-J][1,7]BENZODIAZONIN-1 ONE;CBR113;CS-2206;Sporosin;CGP 39360
CBNumber:
CB2486697
Molecular Formula:
C28H26N4O3
Molecular Weight:
466.54
MDL Number:
MFCD18252446
MOL File:
62996-74-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 00:35:13
Product description Number Pack Size Price
Staurosporine from Streptomyces sp. for molecular biology, ≥95% (HPLC) S5921 0.1mg $339
Staurosporine from Streptomyces sp. for molecular biology, ≥95% (HPLC) S5921 0.5mg $973
Staurosporine from Streptomyces sp. ≥98% (HPLC), film S4400 0.1mg $308
Staurosporine from Streptomyces sp. ≥98% (HPLC), film S4400 0.5mg $928
Staurosporine, Streptomyces sp. Staurosporine,CAS62996-74-,isacell-permeable,potent,reversible,ATP-compe 569397 100μg $184
More product size

STAUROSPORINE Properties

Melting point 270°C
alpha D25 +35.0° (c = 1 in methanol); D22 +56.1° (c = 0.14 in methanol)
Boiling point 677.5±55.0 °C(Predicted)
Density 1.56±0.1 g/cm3(Predicted)
RTECS KD5084000
storage temp. 2-8°C
solubility DMSO: soluble
form White to pale yellow solid
pka 14.25±0.70(Predicted)
color Off white to pale yellow
Water Solubility Soluble in DMSO or ethanol.Soluble in dimethyl sulfoxide , dimethyl formamide, ethyl acetate, hot acetone and ethanol. Slightly soluble in chloroform and methanol. Insoluble in water.
BRN 1060573
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 4 months.
InChIKey HKSZLNNOFSGOKW-WIFUGMKFSA-N
SMILES CN[C@@H]1C[C@@H]2O[C@@](C)([C@@H]1OC)n3c4ccccc4c5c6CNC(=O)c6c7c8ccccc8n2c7c35
CAS DataBase Reference 62996-74-1
NCI Dictionary of Cancer Terms staurosporine
FDA UNII H88EPA0A3N
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  Health Hazard (GHS08)
GHS08
Signal word  Warning
Hazard statements  H361d-H413
Precautionary statements  P201-P202-P273-P280-P308+P313-P405
PPE Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
Hazard Codes  Xn,T,Xi
Risk Statements  40-45-36/37/38-46
Safety Statements  36/37-53-36-26-45
RIDADR  UN 2811 6.1 / PGII
WGK Germany  2
F  8-10
HazardClass  3
HS Code  29419090
Storage Class 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications Aquatic Chronic 4
Carc. 1B
Muta. 1B
Repr. 2
NFPA 704
0
4 0

STAUROSPORINE price More Price(114)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich S5921 Staurosporine from Streptomyces sp. for molecular biology, ≥95% (HPLC) 62996-74-1 0.1mg $339 2026-04-30 Buy
Sigma-Aldrich S5921 Staurosporine from Streptomyces sp. for molecular biology, ≥95% (HPLC) 62996-74-1 0.5mg $973 2026-04-30 Buy
Sigma-Aldrich S4400 Staurosporine from Streptomyces sp. ≥98% (HPLC), film 62996-74-1 0.1mg $308 2026-04-30 Buy
Sigma-Aldrich S4400 Staurosporine from Streptomyces sp. ≥98% (HPLC), film 62996-74-1 0.5mg $928 2026-04-30 Buy
Sigma-Aldrich 569397 Staurosporine, Streptomyces sp. Staurosporine,CAS62996-74-,isacell-permeable,potent,reversible,ATP-compe 62996-74-1 100μg $184 2026-04-30 Buy
Product number Packaging Price Buy
S5921 0.1mg $339 Buy
S5921 0.5mg $973 Buy
S4400 0.1mg $308 Buy
S4400 0.5mg $928 Buy
569397 100μg $184 Buy

STAUROSPORINE Chemical Properties,Uses,Production

Description

Staurosporine (Stsp) is potent inhibitor of protein kinase C (PKC) from rat brain, exhibiting an IC50 value of 2.7 nM. It inhibits rat recombinant PKC-α approximately 100- and 1,000-fold better than PKC-δ and PKC-ζ, respectively. However, Stsp is non-selective in that it also inhibits the activity of a variety of other protein kinases, not only PKC isoforms. The biological effects of Stsp include cytotoxicity, relaxation of smooth muscle, and regulation of eNOS gene expression.

Chemical Properties

Light Yellow Solid

Occurrence

A complex alkaloid. staurosporine has been isolated from a strain of Streptomyces.

Uses

Staurosporine is an unusual indolocarbazole alkaloid produced by a range of actinomycete species. It is a potent antitumour active, inducing apoptosis in a variety of cell lines. Staurosporine is a potent inhibitor of many kinases including protein kinase C, tyrosine kinase, CDK2/cyclin A and CDK4/cyclin D. At submicromolar concentrations, staurosporine inhibits both IKKalpha and IKKbeta.

Uses

Staurosporine is a protein Kinase C inhibitor that induces apoptosis in many cell types.

Definition

ChEBI: Staurosporine is an indolocarbazole alkaloid and an organic heterooctacyclic compound. It has a role as an EC 2.7.11.13 (protein kinase C) inhibitor, a geroprotector, a bacterial metabolite and an apoptosis inducer. It is a conjugate base of a staurosporinium.

General Description

A potent, cell-permeable, reversible, ATP-competitive and broad spectrum inhibitor of protein kinases. Inhibits CaM kinase (IC50 = 20 nM), myosin light chain kinase (IC50 = 1.3 nM), protein kinase A (IC50 = 7 nM), protein kinase C (IC50 = 0.7 nM), and protein kinase G (IC50 = 8.5 nM). Also inhibits platelet aggregation induced by collagen or ADP but has no effect on thrombin-induced platelet aggregation. Induces apoptosis in human malignant glioma cell lines. Arrests normal cells at the G1 checkpoint.

Biological Activity

Broad spectrum protein kinase inhibitor. Enzymes inhibited include protein kinase C (IC 50 = 3 nM), protein kinase A (IC 50 = 7 nM), p 60v-src tyrosine protein kinase (IC 50 = 6 nM) and CaM kinase II (IC 50 = 20 nM). Also available as part of the Mixed Kinase Inhibitor Tocriset™ .

Biochem/physiol Actions

Reversible: yes

storage

+4°C

Background

Staurosporine is an alkaloid isolated from the culture broth of Streptomyces staurosporesa. It is a potent, cell permeable protein kinase C inhibitor with an IC50 of 0.7 nM. At higher concentration, staurosporine also inhibits other kinases such as PKA, PKG, CAMKII and Myosin light chain kinase. At 50-100 nM, it is a functional neurotrophin agonist, promoting neurite outgrowth in neuroblastoma, pheochromocytoma and brain primary neuronal cultures. At 0.2- 1 μM, staurosporine induces cell apoptosis.

References

[1] S OMURA. A new alkaloid AM-2282 OF Streptomyces origin. Taxonomy, fermentation, isolation and preliminary characterization.[J]. Journal of Antibiotics, 1977, 30 4: 275-282. DOI:10.7164/antibiotics.30.275
[2] U T RüEGG  G M B. Staurosporine, K-252 and UCN-01: potent but nonspecific inhibitors of protein kinases.[J]. Trends in pharmacological sciences, 1989, 10 6: 218-220. DOI:10.1016/0165-6147(89)90263-0

195617-12-0
62996-74-1
Synthesis of STAUROSPORINE from 9,13-Epoxy-1H,11H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonine-1,11-dione, 2-[(3,4-dimethoxyphenyl)methyl]-2,3,9,10,12,13-hexahydro-10-methoxy-9-methyl-, 11-(O-methyloxime), [9S-(9α,10β,11Z,13α)]- (9CI)
Global( 452)Suppliers
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ENBRIDGE PHARMTECH CO., LTD.
+8613812269233 tinayang@enbridgepharm.com China 306 58
Chongqing Qiantai Pharma Co., Ltd.
+8615862471140 richardchan@bright-gene.com China 95 58
Hebei Chuanghai Biotechnology Co., Ltd 		+8615350571055 Sibel@chuanghaibio.com China 8738 58
Hangzhou ICH Biofarm Co., Ltd 		+86-0571-28186870; +undefined8613073685410 sales@ichemie.com China 1006 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20122 58
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ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29815 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19936 58

Related articles

View Lastest Price from STAUROSPORINE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
STAUROSPORINE pictures 2026-06-08 STAUROSPORINE
62996-74-1
 0.99 RongNa Biotechnology Co.,Ltd
staurosporine pictures 2026-06-08 staurosporine
62996-74-1
 $1.00 1g ≥98% 20kg/month WUHAN FORTUNA CHEMICAL CO., LTD
Staurosporine pictures 2026-04-20 Staurosporine
62996-74-1
 $56.00-98.00 99.24% 10g TargetMol Chemicals Inc.
  • staurosporine pictures
  • staurosporine
    62996-74-1
  • $1.00
  • ≥98%
  • WUHAN FORTUNA CHEMICAL CO., LTD
  • Staurosporine pictures
  • Staurosporine
    62996-74-1
  • $56.00-98.00
  • 99.24%
  • TargetMol Chemicals Inc.

STAUROSPORINE Spectrum

9,13-Epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-11-(methylamino)-, [9S-(9α,10β,11β,13α)]- InSolution Staurosporine, Streptomyces sp Staurosporineinsolution 9,13-Epoxy-1H,9H-diindolo1,2,3-gh:3,2,1-lmpyrrolo3,4-j1,7benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-11-(methylamino)-, (9S,10R,11R,13R)- Staurosporine, Antibiotic AM-2282 (9S,10R,11R,13R)-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one Antibiotic 230 CGP 39360 [9S-(9alpha,10beta,11beta,13alpha)]-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-1m]pyrrolo[3,4-j][1,7]benzodiazonin-1-one (9S,10α,11α,13β)-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one STAUROSPORINE, STREPTOMYCES SPECIES STAUROSPORINE, STREPTOMYCES STAUROSPOREUS [9S,10α,11α,13β,(+)]-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one [9S-(9α,10β,11β,13α)]-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one Staurosporine,AM-2282,STS yT5720idec Monophosphorothioate, Rp-IsoMer, TriethylaMMoniuM SaltuM Saltnoic acid salt Staurosporine(CGP 41251) ANTIBIOTIC M 193 ANTIBIOTIC AM-2282 [9S-(9A,10B,11B,13A)]-2,3,10,11,12,13-HEXAHYDRO-10-METHOXY-9-METHYL-11-(METHYLAMINO)-9,13-EPOXY-1H,9H-DIINDOLO[1,2,3-GH:3',2',1'-1M]PYRROLO[3,4-J][1,7]BENZODIAZONIN-1-ONE STAUROSPORINE FROM STREPTOMYCES SP. STAUROSPORINE READY-MADE SOLUTION STAUROSPORINE, 99+%. STAUROSPORINE FROM STREPTOMYCES SP MOLECULAR BIOLOGY REAGENT 98+% AM 2282, M 193 STAUROSPORINE FROM STREPTOMYCES SP., PGE WITH 250 UG STAUROSPORINE Staurosporine, 98%, from Streptomyces sp. Staurosporine, 98%, reagent grade STAUROSPORINE USP/EP/BP Staurosporine (AM-2282) US-DMF No.: 034763 CS-2206 CBR113 AM-2282 Stauroporine STSP Star spore fungus (5S,6R,7R,9R)-6-Methoxy-5-methyl-7-(methylamino)-6,7,8,9,15,16-hexahydro-5H,14H-17-oxa-4b,9a,15-triaza-5,9-methanodibenzo[b,h]cyclonona[jkl]cyclopenta[e]-as-indacen-14-one Sporosin Staurosporine (PKC inhibitors) (5S,6R,7R,9R)-6-methoxy-5-methyl-7-(methylamino)-6,7,8,9,15,16-hexahydro-17-oxa-4b,9a,15-triaza-5,9-methanodibenzo[b,h]cyclonona[jkl]cyclopenta[e]-as-indacen-14(5H)-one Astrosporin CCRIS 3272 Star spore fungicide Staurosporine (DMSO solution), protein kinase inhibitor Staurosporine, Protein kinase inhibitor Staurosporine, 10 mM in DMSO Staurosporine, Streptomyces sp. Staurosporine Solution in Ethyl Acetate Staurosporine (STS) (5S,6R,7R,9R)-6-methoxy-5-methyl-7-(methylamino)-5,6,7,8,9,16-hexahydro-17-oxy-4b,9a,15-triaza-5,9-methyldibenzenebenzo[b,h]cyclonylbenzo[jkl]cyclopentylbenzo[e]-as- 2,3,10,11,12,13-HEXAHYDRO-10R-METHOXY-9S-METHYL-11R-METHYLAMINO-9S,13R-EPOXY-1H,9H-DIINDOLO[1,2,3-GH:3',2',1'-LM]PYRROLO[3,4-J][1,7]BENZODIAZONIN-1 ONE Staurosporin Staurosporine,98% 62996-74-1 C28H26N4O3 BioChemical
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